Renal Denervation for Hypertension A Systematic Review and Meta-Analysis of Randomized, Blinded, Placebo-Controlled Trials
Ahmad Y, Francis D, Bhatt D, Howard J. Renal Denervation for Hypertension A Systematic Review and Meta-Analysis of Randomized, Blinded, Placebo-Controlled Trials. JACC Cardiovascular Interventions 2021, 14: 2614-2624. PMID: 34743900, DOI: 10.1016/j.jcin.2021.09.020.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialRenal denervationAntihypertensive medicationsBlood pressureMeta-analysisCatheter-based renal sympathetic denervationEffect of renal denervationRandomized placebo-controlled trialDrug-resistant hypertensionConcomitant antihypertensive medicationOffice blood pressureRenal sympathetic denervationAmbulatory systolic blood pressureRandom-effects meta-analysisSystolic blood pressureEffects of denervationAntihypertensive medication useMagnitude of benefitOffice systolicPlacebo-controlledEfficacy outcomesSympathetic denervationAntihypertensive agentsAmbulatory systolicEligible trialsRandomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis
Ahmad Y, Kane C, Arnold AD, Cook CM, Keene D, Shun-Shin M, Cole G, Al-Lamee R, Francis DP, Howard JP. Randomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis. Cardiovascular Revascularization Medicine 2021, 34: 112-118. PMID: 33551282, PMCID: PMC8813172, DOI: 10.1016/j.carrev.2021.01.031.Peer-Reviewed Original ResearchConceptsRenal denervationRelative risk reductionBlood pressureCatheter-based renal denervationMajor adverse cardiac eventsPlacebo-controlled trial dataAmbulatory diastolic blood pressureAmbulatory systolic blood pressurePlacebo-controlled randomized trialSystolic blood pressure changesOffice diastolic pressureRandomized blinded placeboAdverse cardiac eventsOffice blood pressurePlacebo-controlled trialPrimary efficacy outcomeDiastolic blood pressureRenal sympathetic denervationSystolic blood pressureBlood pressure changesRisk reductionCause mortalityEfficacy outcomesSympathetic denervationAdverse events