2024
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong S, Link T, Gallup T, Qie Y, Li X, Dong S, Schrank B, Grippin A, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong A, Tainer J, Jiang W, Kim B. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nature Biomedical Engineering 2024, 8: 593-610. PMID: 38641710, PMCID: PMC11162332, DOI: 10.1038/s41551-024-01194-7.Peer-Reviewed Original ResearchAntigen-presenting cellsInnate immune pathwaysImmune pathwaysPriming of effector T cellsImmune checkpoint inhibitorsAntitumour immune responseEffector T cellsIntracellular DNA-sensing pathwaysMetastatic breast cancerSyngeneic mouse modelMultiple innate immune pathwaysAdaptive immunogenicityAntitumour responseCheckpoint inhibitorsEndoplasmic reticulum stressT cellsSystemic clearanceBreast cancerDNA-sensing pathwayRelease of mitochondrial DNATherapeutic advantageMouse modelImmune responseEfficient primingIntracellular deliveryPatient-reported health-related quality of life (HRQoL) in the randomized FORMULA-509 trial of salvage radiotherapy and 6 months of GnRH agonist with either bicalutamide or abiraterone acetate plus prednisone (AAP) and apalutamide (Apa) after radical prostatectomy (RP).
Hoffman K, Nguyen P, Rathkopf D, Zurita A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, McKay R, Rose B, Shin K, Kibel A, Taplin M, Kollmeier M. Patient-reported health-related quality of life (HRQoL) in the randomized FORMULA-509 trial of salvage radiotherapy and 6 months of GnRH agonist with either bicalutamide or abiraterone acetate plus prednisone (AAP) and apalutamide (Apa) after radical prostatectomy (RP). Journal Of Clinical Oncology 2024, 42: 260-260. DOI: 10.1200/jco.2024.42.4_suppl.260.Peer-Reviewed Original ResearchAbiraterone acetate plus prednisoneSaint Louis University Mental Status ExamMonths of GnRH agonistPatient-reported health-related quality of lifeEPIC-26Radical prostatectomyHealth-related quality of lifeGnRH agonistTreatment armsHormonal functionPROMIS FatigueTreatment to 1 yearQuality of lifeAcetate plus prednisoneMental statusMetastasis-free survivalBaseline to endMental status examStandardized T scoresMild neurocognitive disorderCompletion of treatmentSalvage radiationSalvage radiotherapyOncological outcomesClinically meaningful differences
2023
FORMULA-509: A Multicenter Randomized Trial of Post-Operative Salvage Radiotherapy (SRT) and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate/Prednisone (AAP) and Apalutamide (Apa) Post-Radical Prostatectomy (RP)
Nguyen P, Kollmeier M, Rathkopf D, Hoffman K, Zurita-Saavedra A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, Mckay R, Rose B, Shin K, Kibel A, Taplin M. FORMULA-509: A Multicenter Randomized Trial of Post-Operative Salvage Radiotherapy (SRT) and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate/Prednisone (AAP) and Apalutamide (Apa) Post-Radical Prostatectomy (RP). International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s81-s82. DOI: 10.1016/j.ijrobp.2023.06.401.Peer-Reviewed Original ResearchPSA progression-free survivalMetastasis-free survivalMonths of GnRH agonistAbiraterone acetate/prednisoneSalvage radiotherapyGnRH agonistPre-planned analysisPost-RPStratification factorsProgression-free survivalPost-radical prostatectomyMedian follow-upSubgroup of patientsMulticenter randomized trialOne-sided type I errorPre-planned subgroup analysisStatistically significant benefitTwo-sided p-valuePelvic nodesOpen-labelPrimary endpointSecondary endpointsInvestigator-initiatedSafety profileAdverse eventsFORMULA-509: A multicenter randomized trial of post-operative salvage radiotherapy (SRT) and 6 months of GnRH agonist with or without abiraterone acetate/prednisone (AAP) and apalutamide (Apa) post-radical prostatectomy (RP).
Nguyen P, Kollmeier M, Rathkopf D, Hoffman K, Zurita A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, McKay R, Rose B, Shin K, Kibel A, Taplin M. FORMULA-509: A multicenter randomized trial of post-operative salvage radiotherapy (SRT) and 6 months of GnRH agonist with or without abiraterone acetate/prednisone (AAP) and apalutamide (Apa) post-radical prostatectomy (RP). Journal Of Clinical Oncology 2023, 41: 303-303. DOI: 10.1200/jco.2023.41.6_suppl.303.Peer-Reviewed Original ResearchPSA progression-free survivalMetastasis-free survivalMonths of GnRH agonistAbiraterone acetate/prednisoneSalvage radiotherapyPre-planned analysisGnRH agonistPost-RPStratification factorsProgression-free survivalPost-radical prostatectomyMedian follow-upMonths of ADTSubgroup of patientsMulticenter randomized trialOne-sided type I errorPre-planned subgroup analysisStatistically significant benefitPelvic nodesOpen-labelPrimary endpointSecondary endpointsInvestigator-initiatedSafety profileAdverse events
2022
Downregulation of Sirt6 by CD38 promotes cell senescence and aging
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X. Downregulation of Sirt6 by CD38 promotes cell senescence and aging. Aging 2022, 14: 9730-9757. PMID: 36490326, PMCID: PMC9792202, DOI: 10.18632/aging.204425.Peer-Reviewed Original ResearchConceptsCD38 expressionSIRT6 expressionC3GCD38 siRNACell senescenceIncreased SIRT6 expressionMechanism of CD38H9c2 cellsInduced to senescenceTelomerase reverse transcriptase levelsReverse transcriptase levelsNK cell levelsPresence of C3GNicotinamide adenine dinucleotidePromote cell senescenceReduced reactive oxygen speciesTNF-a levelsDecreased SIRT6 expressionReactive oxygen speciesD-gal induced senescenceHexokinase 2OSS-128167Myocardial H9c2 cellsStimulate cell proliferationSiRNAAssociation of circulating markers with cognitive decline after radiation therapy for brain metastasis.
Huntoon K, Anderson S, Ballman K, Twohy E, Dooley K, Jiang W, An Y, Li J, von Roemeling C, Qie Y, Ross O, Cerhan J, Whitton A, Greenspoon J, Parney I, Ashman J, Bahary J, Hadjipanayis C, Urbanic J, Farace E, Khuntia D, Laack N, Brown P, Roberge D, Kim B. Association of circulating markers with cognitive decline after radiation therapy for brain metastasis. Neuro-Oncology 2022, 25: 1123-1131. PMID: 36472389, PMCID: PMC10237411, DOI: 10.1093/neuonc/noac262.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyStereotactic radiosurgeryBrain metastasesRadiation therapyNeurocognitive declineSerum levelsRadiation-induced neurocognitive declinePretreatment serum markersLow serum levelsAssociated with neurocognitive impairmentRandomized clinical trialsEnzyme-linked immunosorbent assaySurgical resectionSecondary endpointsSerum markersRetrospective analysisClinical trialsNeurocognitive impairmentCognitive impairmentMetastasisBlood samplesImmunosorbent assayMonthsSecondary analysisTherapyImmunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Lu Y, Huntoon K, Lee D, Wang Y, Ha J, Qie Y, Li X, Schrank B, Dong S, Gallup T, Kang M, Zhao H, An Y, Yang Z, Li J, Kim B, Jiang W. Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy. Nature Nanotechnology 2022, 17: 1332-1341. PMID: 36357792, PMCID: PMC10036139, DOI: 10.1038/s41565-022-01245-7.Peer-Reviewed Original ResearchConceptsInnate immune cellsSolid tumorsImmune cellsEffectiveness of immunotherapyImmune checkpoint blockadeCancer cellsImmune regulatory moleculesHigh response rateCyclic guanosine monophosphate-adenosine monophosphate synthaseBlood cancer cellsInterferon genes (STING) pathwayCheckpoint blockadeCancer immunotherapyHaematological malignanciesImmunotherapyResponse rateTumorsBiological disparitiesLimited responseMember 7Haematologic tumoursDifferential expressionCellsRegulatory moleculesGene pathways
2021
Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer
Buck M, Ghiraldi E, Demkowicz P, Park H, An Y, Kann B, Yu J, Sprenkle P, Kim I, Leapman M. Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer. Urology Practice 2021, 9: 141-149. PMID: 37145694, DOI: 10.1097/upj.0000000000000290.Peer-Reviewed Original ResearchMetastatic prostate cancerLocal therapyProstate cancerLocoregional therapyFacility-level useFacility-level variationM1 prostate cancerDefinitive local therapyNational Cancer DatabaseMetastatic prostate adenocarcinomaClinical practice guidelinesMultilevel logistic regressionM1 diseasePatient factorsTherapy useUninsured statusRadical prostatectomyCancer DatabaseProstate adenocarcinomaHigh comorbidityLocal treatmentPatient levelPractice guidelinesLower oddsPatients245 Factors associated with in-hospital mortality in mycosis fungoides patients
King A, Lee V, Mirza F, Jairam V, Yu J, Park H, Girardi M, Wilson L, An Y. 245 Factors associated with in-hospital mortality in mycosis fungoides patients. Journal Of Investigative Dermatology 2021, 141: s44. DOI: 10.1016/j.jid.2021.02.267.Peer-Reviewed Original ResearchStrong association of glaucoma with atherosclerosis
Song X, Li P, Li Y, Yan X, Yuan L, Zhao C, An Y, Chang X. Strong association of glaucoma with atherosclerosis. Scientific Reports 2021, 11: 8792. PMID: 33888852, PMCID: PMC8062555, DOI: 10.1038/s41598-021-88322-4.Peer-Reviewed Original ResearchConceptsAqueous humor secretionPrimary diagnosisHumor secretionAS prevalencePrimary diagnosis of glaucomaPrimary diagnosis of hypertensionAngle-closure glaucomaHigh intraocular pressureAssociation of glaucomaDiagnosis of glaucomaEffects of methazolamideLow-density lipoprotein (LDLDiagnosis of hypertensionReduce low-density lipoprotein (LDLGlaucoma prevalenceIntraocular pressureLipoprotein (LDLGlaucoma pathogenesisOphthalmic recordsTreat glaucomaAS patientsGlaucomaOphthalmic diseasesMouse modelIncidence of A
2020
Endometrial Cancer
Laird J, An Y, Damast S. Endometrial Cancer. 2020 DOI: 10.1891/9780826155146.0027.Chapters
2019
Upfront Stereotactic Radiosurgery in the Treatment of Brain Metastasis from Small Cell Lung Cancer
Miccio J, Johnson S, Jairam V, Yu J, Hansen J, Aneja S, An Y, Decker R, Omay S, Chiang V, Park H. Upfront Stereotactic Radiosurgery in the Treatment of Brain Metastasis from Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: e81-e82. DOI: 10.1016/j.ijrobp.2019.06.2348.Peer-Reviewed Original ResearchP28 Rectal Radiation Dose Comparison Between Definitive Radiotherapy with Hydrogel Spacer Injection versus Post-prostatectomy Radiotherapy for Prostate Cancer
Yang D, Yu J, An Y, Sprenkle P, Leapman M, Park H. P28 Rectal Radiation Dose Comparison Between Definitive Radiotherapy with Hydrogel Spacer Injection versus Post-prostatectomy Radiotherapy for Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2019, 103: e33. DOI: 10.1016/s0360-3016(19)30478-x.Peer-Reviewed Original ResearchOA01 Impact of Contralateral Lymph Node Involvement on Survival of Surgically-Managed HPV-Positive Oropharyngeal Cancer Staged with the AJCC Eighth Edition
Miccio J, Kelly J, Kann B, An Y, Park H, Verma V, Mehra S, Judson B, Burtness B, Husain Z. OA01 Impact of Contralateral Lymph Node Involvement on Survival of Surgically-Managed HPV-Positive Oropharyngeal Cancer Staged with the AJCC Eighth Edition. International Journal Of Radiation Oncology • Biology • Physics 2019, 103: e1. DOI: 10.1016/s0360-3016(19)30402-x.Peer-Reviewed Original Research
2018
(OA37) High Rate of Distant Metastasis in High-Metastatic Node Number Human Papillomavirus-Positive Oropharyngeal Carcinoma
Lee N, Kelly J, Park H, Author T, An Y, Husain Z. (OA37) High Rate of Distant Metastasis in High-Metastatic Node Number Human Papillomavirus-Positive Oropharyngeal Carcinoma. International Journal Of Radiation Oncology • Biology • Physics 2018, 101: e16. DOI: 10.1016/j.ijrobp.2018.02.076.Peer-Reviewed Original Research
2017
CNS Leukemia
An Y, Roberts K. CNS Leukemia. 2017, 311-333. DOI: 10.1007/978-3-319-55430-3_17.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute lymphoblastic leukemiaAllogeneic stem cell transplantCentral nervous system involvementPediatric acute lymphoblastic leukemiaInduction systemic therapyHigh-risk patientsNervous system involvementTotal body irradiationStem cell transplantUse of radiotherapyHigh cure ratesIntensity of therapyBlood-brain barrierCNS leukemiaCNS relapseCNS lymphomaPalliative therapySystemic therapyPrognostic factorsBody irradiationCell transplantRisk stratificationCure rateCommon cancerEvaluation of Pathology-Based Staging for HPV-Associated Squamous Cell Carcinoma of the Oropharynx in a Large National Sample
Kelly J, An Y, Park H, Yarbrough W, Burtness B, Husain Z. Evaluation of Pathology-Based Staging for HPV-Associated Squamous Cell Carcinoma of the Oropharynx in a Large National Sample. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e347. DOI: 10.1016/j.ijrobp.2017.06.1430.Peer-Reviewed Original ResearchSurvival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation Therapy
Kelly J, An Y, Park H, Yarbrough W, Burtness B, Husain Z. Survival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s43-s44. DOI: 10.1016/j.ijrobp.2017.06.114.Peer-Reviewed Original ResearchCost-Effectiveness of Adjuvant Intravaginal Brachytherapy in High-Intermediate Risk Early Stage Endometrial Carcinoma
Stahl J, Lester-Coll N, Bledsoe T, An Y, Damast S. Cost-Effectiveness of Adjuvant Intravaginal Brachytherapy in High-Intermediate Risk Early Stage Endometrial Carcinoma. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e416. DOI: 10.1016/j.ijrobp.2017.06.1597.Peer-Reviewed Original ResearchCirculating CD4:CD8 Ratio is Prognosticator of Response to Total Skin Electron Beam Radiation in Mycoses Fungoides
An Y, Jiang W, Andraos T, Pinnix C, Milgrom S, Lloyd S, Wilson L, Dabaja B. Circulating CD4:CD8 Ratio is Prognosticator of Response to Total Skin Electron Beam Radiation in Mycoses Fungoides. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e424. DOI: 10.1016/j.ijrobp.2017.06.1618.Peer-Reviewed Original Research