2021
Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children
Mahajerin A, Petty JK, Hanson SJ, Shabanova V, Faustino EVS. Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children. Journal Of Pediatric Hematology/Oncology 2021, 44: e349-e357. PMID: 33885041, DOI: 10.1097/mph.0000000000002167.Peer-Reviewed Original ResearchConceptsReceipt of prophylaxisRisk of VTEVenous thromboembolismInjured childrenRisk prediction modelPharmacologic prophylaxisTrauma Quality Improvement ProgramLow molecular weight heparinHospitalized injured patientsPediatric-specific evidencePractice management guidelinesRandomized clinical trialsMolecular weight heparinQuality Improvement ProgramUnfractionated heparinWeight heparinRetrospective studyInjured patientsClinical trialsProphylaxisManagement guidelinesThromboembolismPatientsHigh rateChildren
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potential
2019
Epidemiology of Clinically Relevant Bleeding in Critically Ill Adolescents.
Pinto MG, Shabanova V, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Tala JA, Faustino EVS. Epidemiology of Clinically Relevant Bleeding in Critically Ill Adolescents. Pediatric Critical Care Medicine 2019, 20: 907-913. PMID: 31261231, DOI: 10.1097/pcc.0000000000002018.Peer-Reviewed Original ResearchConceptsRelevant bleedingVenous thromboembolismIll adolescentsPharmacologic prophylaxisHigh riskClinically Relevant BleedingMulticenter observational studyRandomized clinical trialsRisk of mortalityBleeding eventsTherapeutic anticoagulationMechanical ventilationPulmonary supportClinical trialsObservational studyThromboembolismBleedingAdolescents 13EpidemiologyStatistical significanceAnticoagulationProphylaxisSurgeryAdmissionAdolescents