2019
SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model
Miletta M, Shanabrough M, Sestan-Pesa M, Varela L, Mancini G, Spadaro O, Zeiss C, Dixit V, Dietrich M, Horvath T. SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model. Journal Of The Endocrine Society 2019, 3: sun-097. PMCID: PMC6553392, DOI: 10.1210/js.2019-sun-097.Peer-Reviewed Original ResearchNormal food intakeAgRP neuronsAnorexia nervosaFood intakeFood restrictionActivity-based anorexia (ABA) paradigmWeight lossPostnatal day 36Ad libitumPostnatal day 7Week old micePostnatal day 3Diphtheria toxinHigh mortality rateFed ad libitumAnorexia modelDTR miceHours animalsAd libitum foodNeuronal lossProtein (AgRP) neuronsArcuate nucleusNew neural circuitsPsychiatric illnessOld mice
2012
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
Varela L, Horvath TL. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Reports 2012, 13: 1079-1086. PMID: 23146889, PMCID: PMC3512417, DOI: 10.1038/embor.2012.174.Peer-Reviewed Original ResearchConceptsGlucose homeostasisEnergy homeostasisPrevalence of obesityWhole-body energy homeostasisBody energy homeostasisAnorectic hormonesAgRP neuronsObese patientsProtein (AgRP) neuronsCentral effectsHypothalamic proopiomelanocortinBody weightInsulin actionLeptinHormonal actionMajor targetInsulin pathwayHomeostasisInsulinNeuronsHormoneBrainLatest findingsEnergy balanceSteady rise
2010
Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice
Gyengesi E, Liu ZW, D'Agostino G, Gan G, Horvath TL, Gao XB, Diano S. Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice. Endocrinology 2010, 151: 5395-5402. PMID: 20843996, PMCID: PMC2954711, DOI: 10.1210/en.2010-0681.Peer-Reviewed Original ResearchConceptsNPY/AgRP neuronsSynaptic input organizationSham-operated controlsAgRP neuronsADX miceCorticosterone replacementNeuropeptide YArcuate nucleusSynaptic arrangementsInput organizationPair-fed control animalsPutative excitatory synapsesPutative inhibitory synapsesHypothalamic arcuate nucleusEffects of adrenalectomySham-operated animalsNumber of synapsesPOMC neuronsProtein (AgRP) neuronsOrexigenic actionMembrane potentialSynaptic analysisInhibitory synapsesExcitatory synapsesFood intake