2022
Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm
Cavaliere F, Gülöksüz S. Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm. Npj Mental Health Research 2022, 1: 20. PMID: 38609523, PMCID: PMC10956007, DOI: 10.1038/s44184-022-00018-3.Peer-Reviewed Original ResearchEstimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study
Pries L, Moore T, Visoki E, Sotelo I, Barzilay R, Guloksuz S. Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study. Biological Psychiatry Global Open Science 2022, 2: 283-291. PMID: 36325038, PMCID: PMC9616253, DOI: 10.1016/j.bpsgos.2022.05.005.Peer-Reviewed Original ResearchPregnancy/birth complicationsExposome factorsGeneral psychopathologyBirth complicationsCognitive Development StudyGeneral psychopathology factorAdolescent Brain Cognitive Development (ABCD) studyClinical symptomsAdjusted modelMultiple comparison correctionExposome approachLinear regression analysisMental disordersNeurodevelopmental psychopathologyChildhood adversityPsychosisEnvironmental exposuresABCD studyNongenetic factorsComplicationsRegression analysisPsychopathology factorNeighborhood environmentPsychopathologyExposomeLongitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, Os J, Guloksuz S, Stefanis N. Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study. European Psychiatry 2022, 65: s760-s760. PMCID: PMC9567635, DOI: 10.1192/j.eurpsy.2022.1963.Peer-Reviewed Original ResearchPANSS total scoreFirst-episode psychosisClinical featuresES-SCZTotal scoreIllness coursePsychosis developmentLongitudinal associationsEnvironmental exposuresTime interactionNegative Syndrome ScaleExposome scoreEpisode psychosisSyndrome ScaleSymptom severitySchizophreniaEnvironmental predispositionMultilevel regression analysisScoresRegression analysisFollowPrevious reportsBaselineAssociationCurrent studyExposome and Trans-syndromal Developmental Trajectories Toward Psychosis
Barzilay R, Pries L, Moore T, Gur R, van Os J, Rutten B, Guloksuz S. Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis. Biological Psychiatry Global Open Science 2022, 2: 197-205. PMID: 36325037, PMCID: PMC9616341, DOI: 10.1016/j.bpsgos.2022.05.001.Peer-Reviewed Original ResearchEnvironmental exposuresEarly life environmental exposuresNonspecific clinical presentationClinical presentationTrajectories of riskClinical settingPrenatal periodMental healthDevelopmental cohortGenetic factorsEarly childhoodYounger cohortsCategorical outcomesSensitive periodCohortDevelopmental disordersAdolescent psychopathologyModeling environment through a general exposome factor in two independent adolescent cohorts
Moore T, Visoki E, Argabright S, Didomenico G, Sotelo I, Wortzel J, Naeem A, Gur R, Gur R, Warrier V, Guloksuz S, Barzilay R. Modeling environment through a general exposome factor in two independent adolescent cohorts. Exposome 2022, 2: osac010. PMID: 36606125, PMCID: PMC9798749, DOI: 10.1093/exposome/osac010.Peer-Reviewed Original ResearchExposome factorsOverall psychopathologyAdolescent cohortPubertal developmentEnvironmental exposuresAdvanced pubertal developmentSex-matched sampleKey health-related outcomesHealth-related outcomesCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyGeneral healthCohortPhiladelphia Neurodevelopmental CohortConsistent associationABCD studyObesityNeurodevelopmental CohortParental educationExposurePsychopathologyFactorsPhysical environmental stimuliGender differences in the association between environment and psychosis
Pence AY, Pries LK, Ferrara M, Rutten BPF, van Os J, Guloksuz S. Gender differences in the association between environment and psychosis. Schizophrenia Research 2022, 243: 120-137. PMID: 35287098, DOI: 10.1016/j.schres.2022.02.039.Peer-Reviewed Original ResearchConceptsGender-related differencesChildhood adversityPsychosis riskSubstance useSubstance abuse comorbidityEnvironmental exposuresOnset of illnessAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthPsychosis spectrum disordersHigh prevalencePsychotic disordersPubMed databaseSystematic reviewPsychosisWomenChildhood abuseSymptom dimensionsMenEarly ageAssociationPsychosis expressionFurther investigation
2015
Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma