2022
Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis
Barzilay R, Pries L, Moore T, Gur R, van Os J, Rutten B, Guloksuz S. Exposome and Trans-syndromal Developmental Trajectories Toward Psychosis. Biological Psychiatry Global Open Science 2022, 2: 197-205. PMID: 36325037, PMCID: PMC9616341, DOI: 10.1016/j.bpsgos.2022.05.001.Peer-Reviewed Original ResearchEnvironmental exposuresEarly life environmental exposuresNonspecific clinical presentationClinical presentationTrajectories of riskClinical settingPrenatal periodMental healthDevelopmental cohortGenetic factorsEarly childhoodYounger cohortsCategorical outcomesSensitive periodCohortDevelopmental disordersAdolescent psychopathologyModeling environment through a general exposome factor in two independent adolescent cohorts
Moore T, Visoki E, Argabright S, Didomenico G, Sotelo I, Wortzel J, Naeem A, Gur R, Gur R, Warrier V, Guloksuz S, Barzilay R. Modeling environment through a general exposome factor in two independent adolescent cohorts. Exposome 2022, 2: osac010. PMID: 36606125, PMCID: PMC9798749, DOI: 10.1093/exposome/osac010.Peer-Reviewed Original ResearchExposome factorsOverall psychopathologyAdolescent cohortPubertal developmentEnvironmental exposuresAdvanced pubertal developmentSex-matched sampleKey health-related outcomesHealth-related outcomesCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyGeneral healthCohortPhiladelphia Neurodevelopmental CohortConsistent associationABCD studyObesityNeurodevelopmental CohortParental educationExposurePsychopathologyFactorsPhysical environmental stimuli
2021
Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Wittchen H, Rutten B, Guloksuz S. Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association—The Example of Cannabis and Psychosis. Schizophrenia Bulletin 2021, 47: 594-603. PMID: 33693921, PMCID: PMC8084443, DOI: 10.1093/schbul/sbab019.Peer-Reviewed Original ResearchConceptsFixed-effects modelCannabis usePsychotic experiencesGeneral population cohortRandom-effects modelMental health outcomesRisk factorsTime-varying confoundersProspective associationsPopulation cohortHealth outcomesOwn controlCausal associationPsychosisCannabisLongitudinal studyAssociationBetween-person levelConfoundersCohortIncidenceSchizophrenia