2024
Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Healy C, Byrne J, Raj Suasi S, Föcking M, Mongan D, Kodosaki E, Heurich M, Cagney G, Wynne K, Bearden C, Woods S, Cornblatt B, Mathalon D, Stone W, Cannon T, Addington J, Cadenhead K, Perkins D, Jeffries C, Cotter D. Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms. Brain Behavior And Immunity 2024, 117: 175-180. PMID: 38219978, DOI: 10.1016/j.bbi.2023.12.018.Peer-Reviewed Original ResearchGlobal Assessment of Functioning ScaleNorth American Prodrome Longitudinal StudyClinical high riskPoor functionScale of Psychosis-risk SymptomsPsychosis-risk symptomsAssociated with poorer functioningFirst-episode psychosisTransition to psychosisGreater symptom severityFollow-upIndividuals at-riskClinical symptomsPsychotic disordersHigh riskSymptom severityPsychosocial functioningGlobal functioningPsychosisSubscale scoresFDR correctionAcute phase inflammatory responseLongitudinal studyGlobal assessmentFunctional scales
2023
Relations of Lifetime Perceived Stress and Basal Cortisol with Hippocampal Volume among Healthy Adolescents and those at Clinical High-Risk for Psychosis: A Structural Equation Modeling Approach
Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. Relations of Lifetime Perceived Stress and Basal Cortisol with Hippocampal Volume among Healthy Adolescents and those at Clinical High-Risk for Psychosis: A Structural Equation Modeling Approach. Biological Psychiatry 2023 PMID: 38092185, PMCID: PMC11166888, DOI: 10.1016/j.biopsych.2023.11.027.Peer-Reviewed Original ResearchBilateral hippocampal volumeStructural equation modelingHealthy comparisonsHippocampal volumeBiological sexRelation of ageEquation modelingMultigroup structural equation modelingNorth American Prodrome Longitudinal StudyMeasures of stressNon-human animalsNonspecific risk factorClinical high riskStructural equation modeling approachAdolescent sampleBasal cortisolPerceived stressSmaller hippocampal volumesElevated basal cortisol