2014
Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies
Dulmovits B, Appiah-Kubi A, Papoin J, Gould M, An X, Mohandas N, Gallagher P, Lipton J, Liu J, Blanc L. Pomalidomide Modulates Transcription Networks Regulating Human Erythropoiesis and Globin Switching: Implications for Treatment of Hemoglobinopathies. Blood 2014, 124: 1375. DOI: 10.1182/blood.v124.21.1375.1375.Peer-Reviewed Original ResearchSickle cell diseaseWestern blot analysisΓ-globin productionSide effectsDay 6Painful vaso-occlusive crisesSecond-generation immunomodulatory drugMay-Grunwald Giemsa stainingVaso-occlusive crisisSignificant side effectsQRT-PCRCurrent treatment approachesHbF productionErythroid differentiationBlot analysisFlow cytometric analysisRed cell sicklingMechanism of actionImmunomodulatory drugsNormal samplesPeripheral bloodPharmacologic interventionsCulture systemCell diseaseSimilar dose
2007
A Case of HPP with a Novel Combination of α and β Spectrin Mutations.
Natarajan K, Kutlar F, Li T, Gallagher P, Kutlar A. A Case of HPP with a Novel Combination of α and β Spectrin Mutations. Blood 2007, 110: 1736. DOI: 10.1182/blood.v110.11.1736.1736.Peer-Reviewed Original ResearchAfrican American femalesNon-immune hemolytic anemiaOld diagnosisHistory of splenectomySickle Cell CenterYear old black femaleAmerican femalesHereditary pyropoikilocytosisPathologic examRBC fragmentationEarly satietyPeripheral bloodClinical syndromeRed cell morphologyMonths durationHemolytic anemiaClinical examSevere formLifelong historyAutosomal recessive mannerRed pulpPatientsBlood disordersMembrane cytoskeleton proteinsAge 15