2021
Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso‐occlusive pain: A randomized placebo‐controlled trial in progress
Reyes L, Figueroa J, Leake D, Khemani K, Kumari P, Bakshi N, Lane P, Dampier C, Morris C. Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso‐occlusive pain: A randomized placebo‐controlled trial in progress. American Journal Of Hematology 2021, 97: e21-e24. PMID: 34724240, PMCID: PMC8722015, DOI: 10.1002/ajh.26396.Peer-Reviewed Original ResearchConceptsRandomized placebo-controlled trialVaso-occlusive painPlacebo-controlled trialSickle cell diseaseArginine therapyCell diseasePainTherapyDiseaseTrials
2019
Safety of Intravenous Arginine Therapy in Children with Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain: A Randomized Placebo-Controlled Trial in Progress
Morris C, Figueroa J, Watt A, Khemani K, Kumari P, Barnett M, Bakshi N, Lane P, Dampier C. Safety of Intravenous Arginine Therapy in Children with Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain: A Randomized Placebo-Controlled Trial in Progress. Blood 2019, 134: 995. DOI: 10.1182/blood-2019-122983.Peer-Reviewed Original ResearchVaso-occlusive pain episodesSickle cell diseaseChildren's Hospital OaklandRe-hospitalization rateAdverse eventsSerious AEsArginine bioavailabilityTreatment armsStandard dosePain scoresArginine therapyOpioid useStudy armsUnique patientsCell diseaseInpatient unitTreatment of SCDGrowth hormone stimulation testingGlobal arginine bioavailabilityIntravenous L-arginineLow arginine bioavailabilityParenteral opioid usePhase 2 RCTVaso-occlusive painPlacebo-controlled trial