2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyWildfires increasingly threaten oil and gas wells in the western United States with disproportionate impacts on marginalized populations
González D, Morello-Frosch R, Liu Z, Willis M, Feng Y, McKenzie L, Steiger B, Wang J, Deziel N, Casey J. Wildfires increasingly threaten oil and gas wells in the western United States with disproportionate impacts on marginalized populations. One Earth 2024, 7: 1044-1055. PMID: 39036466, PMCID: PMC11259100, DOI: 10.1016/j.oneear.2024.05.013.Peer-Reviewed Original ResearchWildfire burned areaWestern United StatesBurned areaThreat of wildfireHigh wildfire riskExposure of human populationsWildfire riskWildfireHuman healthClimate changeNational oilHuman populationHistorical threatDisproportionate impactUnited StatesAreaExposureGas wellsClimateOilPopulationWellsGas productionGasResidential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study
Fisher J, Medgyesi D, Deziel N, Nuckols J, Ward M, Jones R. Residential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study. Environment International 2024, 188: 108767. PMID: 38795658, PMCID: PMC11218044, DOI: 10.1016/j.envint.2024.108767.Peer-Reviewed Original ResearchIndustrial sourcesPolychlorinated dibenzo-p-dioxinsRisk of non-Hodgkin lymphomaDibenzo-p-dioxinsPersistent organic pollutantsNIH-AARP DietCoal-fired power plantsPCDD/F sourcesAverage emission indexDioxin emissionsResidential proximityOrganic pollutantsNIH-AARPNon-Hodgkin's lymphomaPeriod prior to enrollmentHigher emissionsElevated risk of non-Hodgkin lymphomaIncident cases of non-Hodgkin's lymphomaEvaluate associationsWind directionAssociated with higher emissionsAssociated with riskNon-Hodgkin lymphoma riskEnrollment addressHealth StudyAccuracy of self-reported distance to nearest unconventional oil and gas well in Pennsylvania, Ohio, and West Virginia residents and implications for exposure assessment
Clark C, Casey J, Bell M, Plata D, Saiers J, Deziel N. Accuracy of self-reported distance to nearest unconventional oil and gas well in Pennsylvania, Ohio, and West Virginia residents and implications for exposure assessment. Journal Of Exposure Science & Environmental Epidemiology 2024, 34: 512-517. PMID: 38448680, DOI: 10.1038/s41370-023-00637-8.Peer-Reviewed Original ResearchSelf-reported distanceWest Virginia residentsAssociated with adverse health outcomesVirginia residentsAdverse health outcomesExposure to environmental hazardsCohen's weighted kappaYears of educationSelf-reported dataHealth outcomesWest VirginiansSelf-report measuresIndicators of awarenessWeighted kappaSelf-reportDemographic characteristicsEducational attainmentAdverse health effectsSelf-reported metricsEnvironmental exposuresDistance categoriesHealth effectsResidentsExposure assessmentRiskNitrate exposure from drinking water and dietary sources among Iowa farmers using private wells
Skalaban T, Thompson D, Madrigal J, Blount B, Espinosa M, Kolpin D, Deziel N, Jones R, Beane Freeman L, Hofmann J, Ward M. Nitrate exposure from drinking water and dietary sources among Iowa farmers using private wells. The Science Of The Total Environment 2024, 919: 170922. PMID: 38350573, DOI: 10.1016/j.scitotenv.2024.170922.Peer-Reviewed Original ResearchConceptsMaximum contaminant levelUrinary nitrate concentrationDietary intakeNitrate concentrationsNitrate excretionNitrate exposureDietary nitrateDrinking waterDietary assessment toolsPrivate wellsAssociated with adverse health risksVulnerable to nitrate contaminationWater nitrate concentrationsNitrate ingestionAdverse health risksAgricultural Health StudyDrinking water intakeMedian intakeProspective cohortUrinary nitrateDietary nitrate ingestionContamination levelsNitrate contaminationNitrate intakeHealth StudyMultiple Dimensions of Environmental Justice and Oil and Gas Development in Pennsylvania
Lieberman-Cribbin W, Fang X, Morello-Frosch R, Gonzalez D, Hill E, Deziel N, Buonocore J, Casey J. Multiple Dimensions of Environmental Justice and Oil and Gas Development in Pennsylvania. Environmental Justice 2024, 17: 31-44. PMID: 38389752, PMCID: PMC10880506, DOI: 10.1089/env.2022.0041.Peer-Reviewed Original ResearchAssessing exposure and health consequences of chemicals in drinking water in the 21st Century
Deziel N, Villanueva C. Assessing exposure and health consequences of chemicals in drinking water in the 21st Century. Journal Of Exposure Science & Environmental Epidemiology 2024, 34: 1-2. PMID: 38429481, DOI: 10.1038/s41370-024-00639-0.Peer-Reviewed Original Research
2023
Predictors of early life residential mobility in urban and rural Pennsylvania children with acute lymphoblastic leukemia and implications for environmental exposure assessment
Clark C, Warren J, Saiers J, Ma X, Bell M, Deziel N. Predictors of early life residential mobility in urban and rural Pennsylvania children with acute lymphoblastic leukemia and implications for environmental exposure assessment. Journal Of Exposure Science & Environmental Epidemiology 2023, 1-10. PMID: 38148338, DOI: 10.1038/s41370-023-00636-9.Peer-Reviewed Original ResearchConventional Fossil Fuel Extraction, Associated Biogeochemical Processes, and Topography Influence Methane Groundwater Concentrations in Appalachia
Li Y, Siegel H, Thelemaque N, Bailey K, Moncrieffe P, Nguyen T, Clark C, Johnson N, Soriano M, Deziel N, Saiers J, Plata D. Conventional Fossil Fuel Extraction, Associated Biogeochemical Processes, and Topography Influence Methane Groundwater Concentrations in Appalachia. Environmental Science And Technology 2023, 57: 19702-19712. PMID: 37982799, DOI: 10.1021/acs.est.3c01862.Peer-Reviewed Original ResearchInvestigation of Sources of Fluorinated Compounds in Private Water Supplies in an Oil and Gas-Producing Region of Northern West Virginia
Siegel H, Nason S, Warren J, Prunas O, Deziel N, Saiers J. Investigation of Sources of Fluorinated Compounds in Private Water Supplies in an Oil and Gas-Producing Region of Northern West Virginia. Environmental Science And Technology 2023, 57: 17452-17464. PMID: 37923386, PMCID: PMC10653085, DOI: 10.1021/acs.est.3c05192.Peer-Reviewed Original ResearchConceptsNorthern West VirginiaMaximum contaminant levelWater supplySurface water concentrationsNearby point sourcesSurface water samplesGas-producing regionsSurface water sourcesPFAS concentrationsPoint sourcesPrivate wellsPublic water supplyGeochemical controlsGroundwater chemistryRecharge zoneWest VirginiaWater wellsInvestigation of sourcesModel resultsPrivate water suppliesPFAS sourcesTopographic characteristicsPFAS transportWater receptorPolyfluoroalkyl substancesUS drinking water quality: exposure risk profiles for seven legacy and emerging contaminants
Levin R, Villanueva C, Beene D, Cradock A, Donat-Vargas C, Lewis J, Martinez-Morata I, Minovi D, Nigra A, Olson E, Schaider L, Ward M, Deziel N. US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants. Journal Of Exposure Science & Environmental Epidemiology 2023, 34: 3-22. PMID: 37739995, PMCID: PMC10907308, DOI: 10.1038/s41370-023-00597-z.Peer-Reviewed Original ResearchPer- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryUrinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samplesEnvironmental Injustice and Cumulative Environmental Burdens in Neighborhoods Near Oil and Gas Development: Los Angeles County, California, and Beyond.
Deziel N. Environmental Injustice and Cumulative Environmental Burdens in Neighborhoods Near Oil and Gas Development: Los Angeles County, California, and Beyond. American Journal Of Public Health 2023, 113: 1173-1175. PMID: 37677114, PMCID: PMC10568509, DOI: 10.2105/ajph.2023.307422.Peer-Reviewed Original ResearchPer- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014
Guo P, Jin Z, Bellia G, Luo J, Inoue K, Pollitt K, Deziel N, Liew Z. Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014. Environmental Research 2023, 237: 117092. PMID: 37683785, DOI: 10.1016/j.envres.2023.117092.Peer-Reviewed Original ResearchSleep disordersSleep outcomesU.S. adultsNHANES 2005Inverse associationSleep durationSerum polyfluoroalkyl substancesCentral nervous systemSerum concentration dataDaily sleep durationExposure tertilesOxidative inflammatory responseQuartile increaseBias analysisInflammatory responseExcessive sleepUncontrolled confoundingNervous systemSleep healthPFAS exposureHealth measuresQuantitative bias analysisLogistic regressionConsistent associationDisordersCOVID-19 and the environment: the pandemic and beyond
Bell M, Pollitt K, Deziel N. COVID-19 and the environment: the pandemic and beyond. Environmental Research Letters 2023, 18: 092001. DOI: 10.1088/1748-9326/acedc8.Peer-Reviewed Original ResearchSteam cracker facilities in the United States: operations, emissions, and sociodemographic patterns of surrounding populations
Johnson N, Bell M, Perez N, Dubrow R, Deziel N. Steam cracker facilities in the United States: operations, emissions, and sociodemographic patterns of surrounding populations. Environmental Research Health 2023, 1: 035003. DOI: 10.1088/2752-5309/acdcb2.Peer-Reviewed Original ResearchResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metricsSocial Vulnerability and Groundwater Vulnerability to Contamination From Unconventional Hydrocarbon Extraction in the Appalachian Basin
Soriano M, Warren J, Clark C, Johnson N, Siegel H, Deziel N, Saiers J. Social Vulnerability and Groundwater Vulnerability to Contamination From Unconventional Hydrocarbon Extraction in the Appalachian Basin. GeoHealth 2023, 7: e2022gh000758. PMID: 37064218, PMCID: PMC10100439, DOI: 10.1029/2022gh000758.Peer-Reviewed Original ResearchGroundwater vulnerabilityLow population densityUOG developmentRapid expansionHigh-volume hydraulic fracturingEnvironmental contaminationStudy regionUnconventional hydrocarbon extractionGroundwater resourcesPopulation densitySocial vulnerabilityGas developmentHigher proportionEnvironmental injusticeContaminationChemical exposureAppalachian BasinHydrocarbon extractionPopulated rural areasBasinVulnerabilityIt’s electric! An environmental equity perspective on the lifecycle of our energy sources
Willis M, Cushing L, Buonocore J, Deziel N, Casey J. It’s electric! An environmental equity perspective on the lifecycle of our energy sources. Environmental Epidemiology 2023, 7: e246. PMID: 37064423, PMCID: PMC10097546, DOI: 10.1097/ee9.0000000000000246.Peer-Reviewed Original Research