2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammation
2016
Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors
Irwin ML, Cartmel B, Harrigan M, Li F, Sanft T, Shockro L, O'Connor K, Campbell N, Tolaney SM, Mayer EL, Yung R, Freedman RA, Partridge AH, Ligibel JA. Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors. Cancer 2016, 123: 1249-1258. PMID: 27893938, PMCID: PMC5360506, DOI: 10.1002/cncr.30456.Peer-Reviewed Original ResearchConceptsCancer survivorsPhysical activityExercise programQuality of lifeDual-energy X-ray absorptiometry scanDana-Farber Cancer InstituteX-ray absorptiometry scansYale Cancer CenterAJCC stage IMajority of patientsThousands of survivorsPrimary endpointAdverse eventsWalk testCancer CenterSerum biomarkersBlood drawBreast cancerLIVESTRONGLower riskYMCA programCancer InstituteStage IBody compositionControl group
2015
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML. Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. Journal Of Clinical Oncology 2015, 34: 669-676. PMID: 26598750, PMCID: PMC4872022, DOI: 10.1200/jco.2015.61.6375.Peer-Reviewed Original ResearchConceptsWeight loss counselingC-reactive protein levelsUsual careTelephone counselingPhysical activityBody compositionSerum biomarkersBreast cancerPerson counselingWeight loss intervention groupStage I breast cancerEffective weight loss strategyWeight lossI breast cancerBreast cancer survivorsBody mass indexBreast cancer mortalityWeight loss strategiesProtein levelsBreast cancer treatmentMean BMIUC groupMass indexCancer survivorsCancer mortality