Featured Publications
Drug-Resistant Tuberculosis, Lebanon, 2016 – 2017 - Volume 25, Number 3—March 2019 - Emerging Infectious Diseases journal - CDC
Achkar S, Demanche C, Osman M, Rafei R, Ismail M, Yaacoub H, Pinçon C, Duthoy S, De Matos F, Gaudin C, Trovato A, Cirillo D, Hamze M, Supply P. Drug-Resistant Tuberculosis, Lebanon, 2016 – 2017 - Volume 25, Number 3—March 2019 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2019, 25: 564-568. PMID: 30789124, PMCID: PMC6390733, DOI: 10.3201/eid2503.181375.Peer-Reviewed Original Research
2022
A global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review
Rafei R, Al Iaali R, Osman M, Dabboussi F, Hamze M. A global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review. Infection Genetics And Evolution 2022, 99: 105258. PMID: 35219865, DOI: 10.1016/j.meegid.2022.105258.Peer-Reviewed Original ResearchConceptsEmm typesMacrolide resistance phenotypeEmm clustersMacrolide resistanceSystematic reviewPeculiar epidemiological featuresPresent systematic reviewEmm pattern AGroup A StreptococcusResistance phenotypeClinical presentationMiddle-income countriesEpidemiological featuresHigh-income countriesExclusion criteriaMacrolide susceptibilityA StreptococcusEpidemiological surveillanceSustained surveillancePattern EPattern AIncome countriesPhenotypeSurveillanceEpidemiological dynamics
2020
Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon
Rafei R, Hawli M, Osman M, Khelissa S, Salloum T, Dabboussi F, Tokajian S, Hamze M. Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon. Future Microbiology 2020, 15: 1555-1569. PMID: 33236928, DOI: 10.2217/fmb-2020-0072.Peer-Reviewed Original ResearchDistribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region
Rafei R, Hawli M, Osman M, Dabboussi F, Hamze M. Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region. Journal Of Global Antimicrobial Resistance 2020, 22: 334-348. PMID: 32084609, DOI: 10.1016/j.jgar.2020.02.005.Peer-Reviewed Original ResearchConceptsInvasive GAS infectionsGAS infectionVaccine candidatesProtein-based vaccine candidatesEpidemiology of groupMacrolide resistance determinantsMacrolide resistance profilesGAS prevalencePharyngitis patientsDisease burdenEmm typesGAS isolatesHealthy carriersSystematic surveillanceResistance profilesErythromycin resistancePotential coverageBurdenResistance determinantsInfectionStreptococciCoverage rateEmm28Emm4Emm89
2017
Typing and comparative genome analysis of Brucella melitensis isolated from Lebanon
Zaki N, Salloum T, Osman M, Rafei R, Hamze M, Tokajian S. Typing and comparative genome analysis of Brucella melitensis isolated from Lebanon. FEMS Microbiology Letters 2017, 364: fnx199. PMID: 28961704, DOI: 10.1093/femsle/fnx199.Peer-Reviewed Original ResearchConceptsGenome analysisLateral gene transferComparative genome analysisDraft genome sequencingWhole-genome single nucleotide polymorphism (SNP) analysisB. melitensisZoonotic disease brucellosisDepth genomic characterizationMultiple virulence determinantsSingle nucleotide polymorphism analysisNucleotide polymorphism analysisSequence divergenceGenome comparisonGenomic islandsSingle nucleotide polymorphismsGenetic variationGenomic characterizationDisease brucellosisGene transferMobile elementsMolecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detection
2013
Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms
Safadi D, Meloni D, Poirier P, Osman M, Cian A, Gaayeb L, Wawrzyniak I, Delbac F, Alaoui H, Delhaes L, Dei-Cas E, Mallat H, Dabboussi F, Hamze M, Viscogliosi E. Molecular Epidemiology of Blastocystis in Lebanon and Correlation between Subtype 1 and Gastrointestinal Symptoms. American Journal Of Tropical Medicine And Hygiene 2013, 88: 1203-1206. PMID: 23458955, PMCID: PMC3752823, DOI: 10.4269/ajtmh.12-0777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlastocystisBlastocystis InfectionsChildChild, PreschoolDNA, ProtozoanFecesFemaleGastrointestinal TractGenotypeHumansInfantLebanonMaleMiddle AgedMolecular EpidemiologyPrevalenceRibosome Subunits, SmallSequence Analysis, DNASpecimen HandlingYoung AdultConceptsLebanese populationCommon eukaryotic parasiteRibosomal RNA gene sequencingRNA gene sequencingAsymptomatic patientsGastrointestinal symptomsSymptomatic patientsSubtype 1Intestinal tractMolecular epidemiologyPatientsBlastocystis subtypesDirect light microscopyFecal samplesPublic healthSubtypesST distributionBlastocystis isolatesBlastocystisGene sequencingParasitesPopulationST1SymptomsEpidemiology