2023
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance
Yassine I, Rafei R, de la Gandara M, Osman M, Fabre L, Dabboussi F, Hamze M, Weill F. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance. Microbial Genomics 2023, 9: 001157. PMID: 38100171, PMCID: PMC10763507, DOI: 10.1099/mgen.0.001157.Peer-Reviewed Original ResearchConceptsExtended-spectrum beta-lactamase genesThird-generation cephalosporinsMultidrug resistance phenotypeBeta-lactamase genesAntimicrobial resistance determinantsPrevalent serogroupsClinical isolatesQuinolone resistanceDNA gyrase genesAntimicrobial resistanceResistance determinantsCTXResistance phenotypeAmino acid substitutionsGyrase genesIsolatesNorth LebanonFirst studyAcid substitutionsPoint mutationsGenomic analysisCephalosporinsEmergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students
Osman M, Yassine I, Hamze M, Al Mir H, Tajani A, Bisha B, Cummings K, Madec J, Haenni M, Kassem I. Emergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students. Microbial Drug Resistance 2023, 30: 101-107. PMID: 38011748, DOI: 10.1089/mdr.2023.0213.Peer-Reviewed Original ResearchLast-resort antibioticsHealthy university studentsExtended-spectrum cephalosporin-resistant isolatesComprehensive antimicrobial stewardship programAntimicrobial stewardship programsColistin-resistant isolatesExtended-spectrum cephalosporinsCephalosporin-resistant isolatesColistin-resistant EnterobacteralesMultidrug-resistant bacteriaMiddle-income countriesEvidence-based practiceAntimicrobial stewardshipStewardship programsOccurrence of resistanceCommunity settingsAntimicrobial resistanceClinical samplesAntibiotic resistanceFecal samplesResistance determinantsAntibioticsPublic healthMultiple factorsIsolates
2021
Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain
Liepa R, Mann R, Osman M, Hamze M, Gunawan C, Hamidian M. Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain. Journal Of Antimicrobial Chemotherapy 2021, 77: 345-350. PMID: 34741594, PMCID: PMC8809195, DOI: 10.1093/jac/dkab399.Peer-Reviewed Original ResearchConceptsWhole genome sequencesWide geographical distributionGene complementNovel variantsPhylogenetic analysisGenomic analysisNew lineageComplete genomeOxford NanoporeIllumina MiSeqGenetic contextResistance genesGenesAntibiotic resistance determinantsResistance phenotypeGeographical distributionCopiesAntibiotic resistance phenotypesResistance islandsGlobal distributionResistance determinantsComM geneAntibiotic resistanceSubcladesVariants
2020
Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region
Rafei R, Hawli M, Osman M, Dabboussi F, Hamze M. Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region. Journal Of Global Antimicrobial Resistance 2020, 22: 334-348. PMID: 32084609, DOI: 10.1016/j.jgar.2020.02.005.Peer-Reviewed Original ResearchConceptsInvasive GAS infectionsGAS infectionVaccine candidatesProtein-based vaccine candidatesEpidemiology of groupMacrolide resistance determinantsMacrolide resistance profilesGAS prevalencePharyngitis patientsDisease burdenEmm typesGAS isolatesHealthy carriersSystematic surveillanceResistance profilesErythromycin resistancePotential coverageBurdenResistance determinantsInfectionStreptococciCoverage rateEmm28Emm4Emm89
2015
Characterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon
Osman M, Nasbeh A, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Characterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon. The International Arabic Journal Of Antimicrobial Agents 2015, 5 DOI: 10.3823/780.Peer-Reviewed Original ResearchClinical isolatesStaphylococcus aureusStaphylococcus aureus infectionS. aureusPrevalence of genesMLS resistance genesMSB phenotypeNini HospitalSignificant morbidityAureus infectionDisc diffusion methodHigh prevalenceLow prevalenceMefA geneNorth LebanonPrevalenceSignificant pathogenL phenotypeResistance determinantsMLS resistanceInducible resistanceAureusErmC genePhenotypeResistance genes