2021
Limits of the Glasgow Coma Scale When Assessing for Sepsis in Allogeneic Hematopoietic Cell Transplant Recipients
Lind M, Rosas M, McFarland L, Taylor L, Olson S, Pergam S. Limits of the Glasgow Coma Scale When Assessing for Sepsis in Allogeneic Hematopoietic Cell Transplant Recipients. Nursing Research 2021, 70: 399-404. PMID: 34039938, PMCID: PMC9110054, DOI: 10.1097/nnr.0000000000000521.Peer-Reviewed Original ResearchMeSH KeywordsGlasgow Coma ScaleHematopoietic Stem Cell TransplantationHumansOdds RatioRetrospective StudiesSepsisTransplantation, HomologousConceptsAllogeneic hematopoietic cell transplant recipientsHematopoietic cell transplant recipientsAcute mental statusGlasgow Coma Scale scoreGlasgow Coma ScaleAcute mental status changesTransplant recipientsSuspected infectionMental status changesInfection onsetMental statusSepsis screening toolComa ScaleHigh-risk populationScreening toolModerate to high sensitivityRisk patientsStatus changesChart reviewGCS scoreSepsis developmentSepsisInfectionModerate sensitivityPatientsAre hematopoietic cell transplant recipients with Gram‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a single center
Lind M, Roncaioli S, Liu C, Bryan A, Sweet A, Tverdek F, Sorror M, Phipps A, Pergam S. Are hematopoietic cell transplant recipients with Gram‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a single center. Immunity Inflammation And Disease 2021, 9: 1786-1794. PMID: 34289529, PMCID: PMC8589361, DOI: 10.1002/iid3.486.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacteremiaHematopoietic Stem Cell TransplantationHumansOutpatientsRetrospective StudiesTransplant RecipientsConceptsGram-negative rod bacteremiaAllogeneic HCT recipientsOutpatient antibiotic treatmentHematopoietic cell transplantationHCT recipientsProportion of treatment timePosttransplant complicationsAntibiotic treatmentAllogeneic hematopoietic cell transplantationHematopoietic cell transplant recipientsOutpatient settingAntibiotic treatment timeBroad-spectrum antibioticsIntravenous antibioticsCell transplantationTransplant recipientsDays posttransplantationTreatment optionsTreatment timePatientsTreatment managementComplicationsInfection characteristicsRecipientsAmbulatory care settingDevelopment and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant
Lind M, Mooney S, Carone M, Althouse B, Liu C, Evans L, Patel K, Vo P, Pergam S, Phipps A. Development and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant. JAMA Network Open 2021, 4: e214514. PMID: 33871619, PMCID: PMC8056279, DOI: 10.1001/jamanetworkopen.2021.4514.Peer-Reviewed Original ResearchConceptsRecipients of allo-HCTSystemic inflammatory response syndromeArea under the curveAllo-HCTHighest area under the curveNational Early Warning ScoreCell transplantationRecipients of allogeneic hematopoietic cell transplantationRecipients of stem cell transplantationTime of culture collectionAllogeneic hematopoietic cell transplantationSequential Organ Failure AssessmentStem cell transplantationHematopoietic cell transplantationInflammatory response syndromePresentation of sepsisOrgan Failure AssessmentFred Hutchinson Cancer Research CenterShort-term mortalityHigh-risk populationCancer Research CenterBloodstream infectionsImmunocompromised recipientsAtypical presentationPrognostic value
2020
Predictive Value of 3 Clinical Criteria for Sepsis (Quick Sequential Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and National Early Warning Score) With Respect to Short-term Mortality in Allogeneic Hematopoietic Cell Transplant Recipients With Suspected Infections
Lind M, Phipps A, Mooney S, Liu C, Fohner A, Patel K, Ueda M, Pergam S. Predictive Value of 3 Clinical Criteria for Sepsis (Quick Sequential Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and National Early Warning Score) With Respect to Short-term Mortality in Allogeneic Hematopoietic Cell Transplant Recipients With Suspected Infections. Clinical Infectious Diseases 2020, 72: 1220-1229. PMID: 32133490, PMCID: PMC8028104, DOI: 10.1093/cid/ciaa214.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeHematopoietic cell transplantationSuspected infectionNational Early Warning ScoreShort-term mortalityAllogeneic hematopoietic cell transplant recipientsAllogeneic hematopoietic cell transplantationHematopoietic cell transplant recipientsSequential Organ Failure AssessmentPredictive valueInflammatory response syndromeOrgan Failure AssessmentAllogeneic HCT recipientsPopulation-specific criteriaImmunocompromised patientsCell transplantationImmunocompromised populationsTransplant recipientsResponse syndromeHCT recipientsClinical criteriaFailure AssessmentEarly Warning ScoreSepsis definitionEnd points
2019
Ventilator-associated events, not ventilator-associated pneumonia, is associated with higher mortality in trauma patients.
Meagher A, Lind M, Senekjian L, Iwuchukwu C, Lynch J, Cuschieri J, Robinson B. Ventilator-associated events, not ventilator-associated pneumonia, is associated with higher mortality in trauma patients. Journal Of Trauma And Acute Care Surgery 2019, 87: 307-314. PMID: 30939576, DOI: 10.1097/ta.0000000000002294.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaVentilator-associated eventsVentilator-free daysTrauma patientsLength of stayMechanical ventilationOccurrence of ventilator-associated eventsAssociated with high mortalityIntensive care unit lengthDays of MVIdentification of modifiable risk factorsHospital length of stayRetrospective cohort studyDefinition of ventilator-associated pneumoniaAdult trauma patientsInjured trauma patientsModifiable risk factorsTrauma registry dataLikelihood of deathRetrospective reviewPhysician adjudicationClinical outcomesAbbreviated Injury Scale head scoreCohort studyHospital length