2021
Are hematopoietic cell transplant recipients with Gram‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a single center
Lind M, Roncaioli S, Liu C, Bryan A, Sweet A, Tverdek F, Sorror M, Phipps A, Pergam S. Are hematopoietic cell transplant recipients with Gram‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a single center. Immunity Inflammation And Disease 2021, 9: 1786-1794. PMID: 34289529, PMCID: PMC8589361, DOI: 10.1002/iid3.486.Peer-Reviewed Original ResearchConceptsGram-negative rod bacteremiaAllogeneic HCT recipientsOutpatient antibiotic treatmentHematopoietic cell transplantationHCT recipientsProportion of treatment timePosttransplant complicationsAntibiotic treatmentAllogeneic hematopoietic cell transplantationHematopoietic cell transplant recipientsOutpatient settingAntibiotic treatment timeBroad-spectrum antibioticsIntravenous antibioticsCell transplantationTransplant recipientsDays posttransplantationTreatment optionsTreatment timePatientsTreatment managementComplicationsInfection characteristicsRecipientsAmbulatory care settingDevelopment and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant
Lind M, Mooney S, Carone M, Althouse B, Liu C, Evans L, Patel K, Vo P, Pergam S, Phipps A. Development and Validation of a Machine Learning Model to Estimate Bacterial Sepsis Among Immunocompromised Recipients of Stem Cell Transplant. JAMA Network Open 2021, 4: e214514. PMID: 33871619, PMCID: PMC8056279, DOI: 10.1001/jamanetworkopen.2021.4514.Peer-Reviewed Original ResearchConceptsRecipients of allo-HCTSystemic inflammatory response syndromeArea under the curveAllo-HCTHighest area under the curveNational Early Warning ScoreCell transplantationRecipients of allogeneic hematopoietic cell transplantationRecipients of stem cell transplantationTime of culture collectionAllogeneic hematopoietic cell transplantationSequential Organ Failure AssessmentStem cell transplantationHematopoietic cell transplantationInflammatory response syndromePresentation of sepsisOrgan Failure AssessmentFred Hutchinson Cancer Research CenterShort-term mortalityHigh-risk populationCancer Research CenterBloodstream infectionsImmunocompromised recipientsAtypical presentationPrognostic value
2020
281. Detecting bacterial sepsis among allogeneic HCT recipients with population-specific bedside tools
Lind M, Pergam S, Liu C, Phipps A, Mooney S, Althouse B, Carone M. 281. Detecting bacterial sepsis among allogeneic HCT recipients with population-specific bedside tools. Open Forum Infectious Diseases 2020, 7: s140-s141. PMCID: PMC7777916, DOI: 10.1093/ofid/ofaa439.325.Peer-Reviewed Original ResearchAllogeneic hematopoietic cell transplantationSystemic inflammatory response syndromeAllogeneic hematopoietic cell transplant recipientsHigh-risk populationNational Early Warning ScoreSepsis eventsSequential Organ Failure AssessmentDetecting bacterial sepsisPotential infectionHematopoietic cell transplantationSepsis related mortalityInflammatory response syndromeOrgan Failure AssessmentRespiratory rateAllogeneic HCT recipientsDays post-transplantationDiastolic blood pressureCell transplantationBacterial sepsisResponse syndromeHCT recipientsPost-transplantationDiagnosing sepsisClinical factorsFailure AssessmentA Targeted Screening Program for Latent Tuberculosis Infection Among Hematopoietic Cell Transplant Recipients
Sosa-Moreno A, Narita M, Spitters C, Swetky M, Podczervinski S, Lind M, Holmberg L, Liu C, Edelstein R, Pergam S. A Targeted Screening Program for Latent Tuberculosis Infection Among Hematopoietic Cell Transplant Recipients. Open Forum Infectious Diseases 2020, 7: ofaa224. PMID: 32671130, PMCID: PMC7348235, DOI: 10.1093/ofid/ofaa224.Peer-Reviewed Original ResearchHematopoietic cell transplant recipientsTuberculin skin testLatent tuberculosis infectionQuantiFERON-TB GoldHematopoietic cell transplantationLatent tuberculosis infection testingElectronic medical recordsTargeted screening programScreening programRisk factorsTuberculosis infectionPrevalence of latent tuberculosis infectionTargeted tuberculin skin testingTuberculin skin test resultsProgression to active tuberculosisNegative QFT resultsElectronic medical record reviewRetrospective cohort studyLow-prevalence populationsQFT resultsCell transplantationTransplant recipientsActive tuberculosisLTBI testingSkin testPredictive Value of 3 Clinical Criteria for Sepsis (Quick Sequential Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and National Early Warning Score) With Respect to Short-term Mortality in Allogeneic Hematopoietic Cell Transplant Recipients With Suspected Infections
Lind M, Phipps A, Mooney S, Liu C, Fohner A, Patel K, Ueda M, Pergam S. Predictive Value of 3 Clinical Criteria for Sepsis (Quick Sequential Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and National Early Warning Score) With Respect to Short-term Mortality in Allogeneic Hematopoietic Cell Transplant Recipients With Suspected Infections. Clinical Infectious Diseases 2020, 72: 1220-1229. PMID: 32133490, PMCID: PMC8028104, DOI: 10.1093/cid/ciaa214.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeHematopoietic cell transplantationSuspected infectionNational Early Warning ScoreShort-term mortalityAllogeneic hematopoietic cell transplant recipientsAllogeneic hematopoietic cell transplantationHematopoietic cell transplant recipientsSequential Organ Failure AssessmentPredictive valueInflammatory response syndromeOrgan Failure AssessmentAllogeneic HCT recipientsPopulation-specific criteriaImmunocompromised patientsCell transplantationImmunocompromised populationsTransplant recipientsResponse syndromeHCT recipientsClinical criteriaFailure AssessmentEarly Warning ScoreSepsis definitionEnd pointsTrends in the Proportion of Time Spent Outpatient While Receiving Antibiotics for Treatment of Gram-Negative Rod Bacteremia Among Allogeneic Hematopoietic Cell Transplant Recipients
Lind M, Roncaioli S, Phipps A, Liu C, Bryant A, Sweet A, Pergam S. Trends in the Proportion of Time Spent Outpatient While Receiving Antibiotics for Treatment of Gram-Negative Rod Bacteremia Among Allogeneic Hematopoietic Cell Transplant Recipients. Transplantation And Cellular Therapy 2020, 26: s320-s321. DOI: 10.1016/j.bbmt.2019.12.343.Peer-Reviewed Original ResearchGram-negative rod bacteremiaAllogeneic HCT recipientsProportion of treatment timeHematopoietic cell transplantationMultidrug-resistant organismsHCT recipientsAllogeneic hematopoietic cell transplant recipientsInpatient intravenous antibiotic therapyAllogeneic hematopoietic cell transplantationHematopoietic cell transplant recipientsOutpatient settingIntravenous antibiotic therapySeverity of illnessMDR statusAntibiotic durationBlood culturesAntibiotic therapyCell transplantationTransplant recipientsReceiving antibioticsAdult patientsAntibiotic treatmentTreatment timeAntibiotic deliveryOutpatient management