2000
Significant interaction between clozapine and cocaine in cocaine addicts
Farren C, Hameedi F, Rosen M, Woods S, Jatlow P, Kosten T. Significant interaction between clozapine and cocaine in cocaine addicts. Drug And Alcohol Dependence 2000, 59: 153-163. PMID: 10891628, DOI: 10.1016/s0376-8716(99)00114-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultArousalClozapineCocaineCocaine-Related DisordersComorbidityDose-Response Relationship, DrugDrug InteractionsEuphoriaHumansMaleRisk FactorsSchizophreniaSyncopeConceptsSerum cocaine levelsCocaine levelsClozapine pretreatmentIntranasal cocaineBaseline pulse rateNear-syncopal eventsSignificant pressor effectSystolic blood pressureDoses of clozapinePossible therapeutic roleDose-dependent mannerMale cocainePressor effectSyncopal episodesBlood pressureOral challengeSingle doseBlood levelsTherapeutic roleClozapineCocaine addictionPulse rateCocaineDoseDependent mannerEffects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1999
Interactions of Cocaine with Nimodipine: A Brief Report
Kosten T, Woods S, Rosen M, Pearsall H. Interactions of Cocaine with Nimodipine: A Brief Report. American Journal On Addictions 1999, 8: 77-81. PMID: 10189518, DOI: 10.1080/105504999306117.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcium Channel BlockersCocaineDose-Response Relationship, DrugDouble-Blind MethodDrug InteractionsFemaleHumansMaleMiddle AgedNimodipine
1998
Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure
Oliveto A, Rosen M, Kosten T, Hameedi F, Woods S, Kosten T. Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure. Experimental And Clinical Psychopharmacology 1998, 6: 169-178. PMID: 9608349, DOI: 10.1037/1064-1297.6.2.169.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiscrimination LearningDose-Response Relationship, DrugFemaleHumansHydromorphoneMaleMethadoneNaloxoneOpioid-Related DisordersConceptsNaloxone-appropriate respondingNovel-appropriate respondingDose-related increaseNovel-response drug discrimination procedureOpioid-dependent humansDose-related decreaseDrug discrimination procedureHuman laboratory modelOpioid withdrawalDiscrimination procedureNaloxoneHydromorphoneNonhuman dataAppropriate respondingRespondingPlaceboMethadone
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original ResearchDose Dependent Effects of Yohimbine on Methadone Maintained Patients
Hameedi F, Woods S, Rosen M, Pearsall H, Kosten T. Dose Dependent Effects of Yohimbine on Methadone Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1997, 23: 327-333. PMID: 9143642, DOI: 10.3109/00952999709040950.Peer-Reviewed Original ResearchTreatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T
Kosten T, Rosen M, McMahon T, Bridge T, O'malley S, Pearsall R, O'connor P. Treatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T. The American Journal Of Drug And Alcohol Abuse 1997, 23: 543-553. PMID: 9366972, DOI: 10.3109/00952999709016894.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodHumansMaleMiddle AgedNeuropsychological TestsPeptide TSubstance Abuse, Intravenous
1996
Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Rosen M, McMahon T, Hameedi F, Pearsall H, Woods S, Kreek M, Kosten T. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 1128-35. PMID: 8786543.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBlood PressureBody TemperatureClonidineDose-Response Relationship, DrugFemaleHumansHydrocortisoneMaleNaloxoneSubstance Withdrawal SyndromeConceptsClonidine pretreatmentOpiate withdrawalAdrenocorticotropic hormone (ACTH) responseDiastolic blood pressureNaloxone-precipitated opiate withdrawalNaloxone challenge testHeroin-dependent subjectsMeasures of withdrawalNasal congestionBlood pressureNew medicationsWithdrawal severityTesting medicationsChallenge testPlasma cortisolHormone responseConsecutive daysPilot studyClonidineMedicationsPositive controlWithdrawalBase linePretreatmentTwo-factor analysis
1994
Buprenorphine: duration of blockade of effects of intramuscular hydromorphone
Rosen M, Wallace E, McMahon T, Pearsall H, Woods S, Price L, Kosten T. Buprenorphine: duration of blockade of effects of intramuscular hydromorphone. Drug And Alcohol Dependence 1994, 35: 141-149. PMID: 7519977, DOI: 10.1016/0376-8716(94)90121-x.Peer-Reviewed Original Research