2009
Proton Pump Inhibitors and Bone Fractures?
Laine L. Proton Pump Inhibitors and Bone Fractures? The American Journal Of Gastroenterology 2009, 104: ajg200948. PMID: 19262543, DOI: 10.1038/ajg.2009.48.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProton pump inhibitorsAverage daily dosePPI useHip fractureDaily dosePump inhibitorsReceptor antagonistContinuous proton-pump inhibitorsCase-control studyPotential confounding factorsDose-response relationshipLack of associationManitoba patientsAppropriate indicationsUK patientsCalcium absorptionFracture riskMEDLINE searchBone fracturesHigh dosesConfounding factorsCausal associationDuration responseRelevant articlesLonger duration
2008
Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials
Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.Peer-Reviewed Original ResearchConceptsEndoscopic therapyProton pump inhibitorsActive bleedingVisible vesselPump inhibitorsIntravenous proton pump inhibitorsAppropriate endoscopic treatmentNonbleeding visible vesselPrimary end pointSecond-look endoscopyEndoscopic hemostatic therapyRandomized Controlled TrialsEvidence-based approachPlacebo/Further bleedingHemostatic therapyInjection therapyControlled TrialsEndoscopic treatmentRandomized trialsBleeding ulcersSclerosant therapyReceptor antagonistBibliographic database searchBleeding