About
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Associate Research Scientist
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Lichong Yan's published research.
Publications Timeline
A big-picture view of Lichong Yan's research output by year.
Bing Su, PhD, MPH
Lei Shen
6Publications
225Citations
Publications
2024
SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
Qi J, Yan L, Sun J, Huang C, Su B, Cheng J, Shen L. SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314619121. PMID: 38776375, PMCID: PMC11145296, DOI: 10.1073/pnas.2314619121.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPaired box protein 5GC B cellsSUMO-specific protease 1Activation-induced cytidine deaminaseProtein SUMOylationClass switch recombinationProtein stabilityB cellsProtease 1B cell responsesProtein 5Cytidine deaminaseSENP1Up-regulatedGC B cell responsesSomatic hypermutationSUMOylationDeSUMOylationGerminal centersHigher affinityProduction of class-switched antibodiesGerminal center B cell responsesGC reactionMemory B cellsClass-switched antibodies
2020
One Ring to Rule Them All: Mitochondrial Circular RNAs Control Mitochondrial Function
Yan L, Chen YG. One Ring to Rule Them All: Mitochondrial Circular RNAs Control Mitochondrial Function. Cell 2020, 183: 11-13. PMID: 33007261, DOI: 10.1016/j.cell.2020.09.028.Commentaries, Editorials and LettersCitationsAltmetricMeSH Keywords and ConceptsCircular RNAs in Immune Response and Viral Infection
Yan L, Chen YG. Circular RNAs in Immune Response and Viral Infection. Trends In Biochemical Sciences 2020, 45: 1022-1034. PMID: 32900574, PMCID: PMC7642119, DOI: 10.1016/j.tibs.2020.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsCircular RNAsImmune responseDifferent biological rolesCellular abundanceViral circRNAsCircRNAs expressionBiological functionsBiological roleCircRNAsDNA virusesAutoimmune disordersImmune regulationDiverse classViral infectionClass of moleculesImmune systemRNACurrent understandingPotential roleInfectionEukaryotesFuture investigations
2019
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F, Su B. Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. Cellular & Molecular Immunology 2019, 16: 757-769. PMID: 30705387, PMCID: PMC6804816, DOI: 10.1038/s41423-018-0185-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCell growthActivation of mTORC2MTOR complex 2B cell growthAkt-dependent inactivationC-myc proteinMolecular mechanismsSIN1Molecular levelGenetic ablationB cell-mediated immunitySpecific roleCell sizeMetabolismB cell proliferationComplexes 2GrowthAnti-viral immunityMTORC2GSK3B cellsMYCKey componentProteinTransitional stage
2018
Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets
Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J. Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arteriosclerosis Thrombosis And Vascular Biology 2018, 38: 1. PMID: 30571167, DOI: 10.1161/atvbaha.118.311822.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAnimalsBlood PlateletsCarrier ProteinsCell HypoxiaDisease Models, AnimalFemaleHumansMaleMechanistic Target of Rapamycin Complex 2Mice, Inbred C57BLMice, KnockoutMiddle AgedMyocardial InfarctionPhosphorylationPlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionSirtuin 3Superoxide DismutaseThrombosisConceptsOxygen speciesTarget AktSIN1Reactive oxygen speciesHypoxia responseNovel roleMyocardial infarctionIntegrin αIIbβ3Downstream signalsValuable therapeutic targetCell proliferationAktDeficiency micePhosphorylationST-segment elevation myocardial infarctionPlatelet activationLeft anterior descending (LAD) obstructionPump coronary artery bypassSignalingSpeciesTherapeutic targetΑIIbβ3Coronary artery bypassInhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Wu ZR, Yan L, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B, Wu ZB. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours. Nature Communications 2018, 9: 4624. PMID: 30397197, PMCID: PMC6218470, DOI: 10.1038/s41467-018-06853-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCabergolineCarcinogenesisCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationDisease ProgressionDown-RegulationFemaleHEK293 CellsHeterograftsHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MicePhosphoproteinsPhosphorylationPituitary NeoplasmsRibosomal Protein S6 Kinases, 70-kDaRNA, Long NoncodingUp-RegulationConceptsPituitary tumorsTumor growthTumor progressionLong noncoding RNA H19Potential therapeutic targetTumor growth regulationHuman pituitary tumorsFunction of H19Pituitary tumor cell proliferationTumor cell proliferationPrimary pituitary adenomaCabergoline treatmentPituitary adenomasTherapeutic targetInhibition of mTORC1RNA H19LncRNA H19H19 expressionAberrant expressionTumorsCell proliferationProgressionH19Growth regulationAdenomas
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