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Krishna C. Mudumbi, PhD

Associate Research Scientist in Pharmacology
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Titles

Associate Research Scientist in Pharmacology

Biography

Krishna is interested in exploring the kinetics of receptor tyrosine kinase (RTK) signaling through the use of biophysical techniques, with a focus on single-molecule microscopy. He gained experience in single-molecule microscopy during his Ph.D. work in the lab of Weidong Yang at Temple University studying nuclear envelope membrane proteins. During his time there, he studied the translocation of nuclear envelope transmembrane proteins into the nucleus, as well as developed a single-molecule FRAP technique to study the distribution of transmembrane proteins on the nuclear envelope.

In Mark Lemmon's lab, Krishna is using his expertise with single-molecule microscopy to understand how the dynamics of EGFR dimerization contribute to its signaling. Using single-particle tracking, his work recently revealed how the different domains of EGFR contribute to its dimerization and oligomerization on the cell surface. He continues to use advanced imaging techniques, cellular, and biochemical assays to explore how the kinetics and spatial organization of EGFR on the plasma membrane defines signaling specificity.

Appointments

Other Departments & Organizations

Education & Training

PhD
Temple University, Biophysics
BA
Emory University

Research

Research at a Glance

Yale Co-Authors

Frequent collaborators of Krishna C. Mudumbi's published research.

Publications

2023

2021

2020

2019

2017

2016

2013

Academic Achievements & Community Involvement

  • honor

    Intersections Science Fellow

  • honor

    MIT Biology Catalyst Fellow

  • honor

    Duke Next Generation Leader

  • honor

    Capital High School Distinguished Alumni

  • honor

    Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00)

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