2023
Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil
de Oliveira L, de Rezende I, Navarini V, Marchioro S, Torres A, Croda J, Croda M, Gonçalves C, Xavier J, de Castro E, Lima M, Iani F, Adelino T, Aburjaile F, Demarchi L, Taira D, Zardin M, Fonseca V, Giovanetti M, Andrews J, Alcantara L, Simionatto S. Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil. Frontiers In Public Health 2023, 11: 1195779. PMID: 37965526, PMCID: PMC10641392, DOI: 10.3389/fpubh.2023.1195779.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 lineagesIntroduction eventsCharacterization of SARS-CoV-2Nanopore sequencing platformSARS-CoV-2 positive samplesMultiple SARS-CoV-2 variantsMultiple introduction eventsPhylogenetic reconstructionPhylogenetic dataGenome sequenceSequencing platformsGenomic characterizationSARS-CoV-2Genomic surveillanceSARS-CoV-2 variantsLineagesMato GrossoMortality rateViral dynamicsIndigenous populationCo-circulationPrevalence of malesMidwestern BrazilPositive samplesIndigenous mobilizationDelay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil
Ribeiro C, da Silva Santos A, Tshua D, de Oliveira R, Lemos E, Bourdillon P, Laranjeira A, Gonçalves C, Andrews J, Ko A, Croda J. Delay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0015-2023. PMID: 37493729, PMCID: PMC10367220, DOI: 10.1590/0037-8682-0015-2023.Peer-Reviewed Original ResearchConceptsSymptom onsetFirst symptomsLargest male prisonPrison medical recordsTB case dataRetrospective cohort studyPulmonary TB casesYear of diagnosisStart of treatmentTreatment of TBTreatment of tuberculosisNumber of symptomsAverage timePercentage of cureProvider delayTB casesCohort studyTreatment initiationHIV statusSmoking statusTuberculosis casesTB transmissionFirst consultationPatient delayMedical records
2022
HTLV infection in Brazil’s second-largest indigenous reserve
Amianti C, Bandeira L, Cesar G, Weis-Torres S, Tanaka T, Machado I, Gonçalves C, Simionatto S, Schnaufer E, Freitas F, Vallinoto A, Croda J, Motta-Castro A. HTLV infection in Brazil’s second-largest indigenous reserve. Scientific Reports 2022, 12: 16701. PMID: 36202887, PMCID: PMC9537150, DOI: 10.1038/s41598-022-21086-7.Peer-Reviewed Original ResearchConceptsHTLV infectionHTLV-1HTLV-2HTLV-1-associated myelopathyAdult T-cell leukemia/lymphomaHuman T-lymphotropic virus 1T-cell leukemia/lymphomaChronic inflammatory neurological diseaseHTLV-1 prevalenceInflammatory neurological diseasesHTLV-2 infectionAggressive malignant diseaseLeukemia/lymphomaEnzyme-linked immunosorbentMedian agePregnant populationMalignant diseaseBlood donorsStudy populationDrug usersNeurological diseasesCosmopolitan subtypeWestern blotSerum samplesDisease
2021
Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves
Santos E, Silva-Filho S, Santos Radai J, Arena A, Fraga T, Lima Cardoso C, Croda J, Leite Kassuya C. Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves. Journal Of Ethnopharmacology 2021, 278: 114308. PMID: 34102271, DOI: 10.1016/j.jep.2021.114308.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesMethylthiazolyldiphenyl-tetrazolium bromideComplete Freund's adjuvantAnti-inflammatory featuresEthanolic extractLong-term treatmentBacillus Calmette-GuerinInflammatory evaluationInflammatory parametersConventional medicationsDaily administrationNeutrophil activityPersistent inflammationRheumatic diseasesFreund's adjuvantInflammatory aspectsPleurisy modelTraditional folk medicineSwiss miceCalmette-GuerinInflammatory diseasesC57BL6 miceVivo modelExperimental modelAdverse effectsRisk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil
da Silva P, de Oliveira S, Escalante J, Almiron M, Tsuha D, Sato H, Menezes P, de Paula R, D’Agostini T, Croda J. Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil. American Journal Of Tropical Medicine And Hygiene 2021, 105: 88-92. PMID: 34061773, PMCID: PMC8274770, DOI: 10.4269/ajtmh.20-1598.Peer-Reviewed Original ResearchConceptsCOVID-19Confirmed COVID-19Characteristics of patientsChronic lung diseaseIntensive care unitChronic cardiovascular diseaseChronic neurological diseaseMore comorbiditiesClinical characteristicsDiabetes mellitusMedian ageCare unitLung diseaseRisk factorsCardiovascular diseaseHigh riskSevere casesElderly individualsPatientsNeurological diseasesSurvival analysisCoronavirus diseaseDiseaseSão PauloDeath
2020
Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay
Sequera V, Aguirre S, Estigarribia G, Cellamare M, Croda J, Andrews J, Martinez L, García-Basteiro A. Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay. Scientific Reports 2020, 10: 21247. PMID: 33277515, PMCID: PMC7718226, DOI: 10.1038/s41598-020-77504-1.Peer-Reviewed Original ResearchConceptsTB casesPopulation attributable fractionAttributable fractionAnnual TB notification ratesNational TB Control ProgrammeOverall population attributable riskIncarcerated populationsTB control programsCharacteristics of tuberculosisPopulation attributable riskTB notification ratesTB control measuresTrend of tuberculosisPercentage of casesSame age groupIncarcerated casesTB burdenTB controlTuberculosis burdenCase RegistryTuberculosis controlTB epidemicAttributable riskNotification ratesRelative riskCaryocar brasiliense Cambess. Pulp Oil Supplementation Reduces Total Cholesterol, LDL-c, and Non-HDL-c in Animals
Silva G, Di Pietro Fernandes C, Hiane P, de Cássia Freitas K, Figueiredo P, Inada A, Filiú W, Maldonade I, Nunes Â, de Oliveira L, Caires A, Michels F, Candido C, Cavalheiro L, Asato M, Donadon J, de Faria B, Tatara M, Croda J, Pott A, Nazário C, de Cássia Avellaneda Guimarães R. Caryocar brasiliense Cambess. Pulp Oil Supplementation Reduces Total Cholesterol, LDL-c, and Non-HDL-c in Animals. Molecules 2020, 25: 4530. PMID: 33022905, PMCID: PMC7582708, DOI: 10.3390/molecules25194530.Peer-Reviewed Original ResearchAntimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment
Vasconcelos N, Vaz M, Radai J, Kassuya C, Formagio A, Graciani F, Leal M, Oliveira R, da Silva K, Croda J, Simionatto S. Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment. Journal Of Toxicology And Environmental Health Part A 2020, 83: 719-729. PMID: 32981476, DOI: 10.1080/15287394.2020.1824135.Peer-Reviewed Original ResearchConceptsSwiss male miceMultidrug-resistant strainsSplenic phagocytosisMale miceAgar disk diffusionBeneficial effectsToxicological assessmentMicronucleus assayKlebsiella pneumoniaePlant extractsVivo toxicological assessmentDisk diffusionAntibioticsAntimicrobial activityMutagenic activityGlobal spreadExtractMolecular characterizationAssessmentAntibacterial activityActivityMiceActive productsSynergismBlutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentrationGestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study
Sousa I, Souza C, Barbosa M, Croda J, Gonçalves C, Bernardes S, Marchioro S. Gestational outcomes in women infected by Zika virus during pregnancy in Mato Grosso do Sul, Brazil: A cross-sectional study. International Journal Of Infectious Diseases 2020, 98: 359-365. PMID: 32619757, DOI: 10.1016/j.ijid.2020.06.084.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeZIKV infectionCross-sectional studyGestational outcomesZika virusNormal-appearing infantMain clinical findingsCase fatality rateMother-infant pairsMothers of infantsQRT-PCRZika syndromeClinical caveatsClinical findingsClinical parametersFirst trimesterCongenital alterationsLive birthsLaboratory confirmationCongenital abnormalitiesFatality rateEpidemic burstsInfectionPregnancyInfantsEffect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet
Cardozo C, Inada A, Cardoso C, de Oliveira Filiú W, de Farias B, Alves F, Tatara M, Croda J, de Cássia Avellaneda Guimarães R, Hiane P, de Cássia Freitas K. Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet. Molecules 2020, 25: 2693. PMID: 32531999, PMCID: PMC7321075, DOI: 10.3390/molecules25112693.Peer-Reviewed Original ResearchConceptsHigh-fat dietInterleukin-6Diet-induced obesity modelBeneficial effectsHydroethanolic extractMale Swiss miceHydroethanolic leaf extractEffect of supplementationLipid parametersMice fedAdiposity gainFat dietSwiss miceObesity modelObesity featuresMetabolic parametersFood intakeHistological parametersMetabolic disordersBody weightNutrition dietProtein expressionDietFood behaviorFurther investigationPrevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study
Rezende G, Lago B, Puga M, Bandeira L, Pompilio M, Castro V, Tanaka T, Cesar G, Oliveira S, Yassuda R, Simionatto S, Weis S, Basílio S, Croda J, Motta-Castro A. Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study. International Journal Of Infectious Diseases 2020, 96: 298-307. PMID: 32315810, DOI: 10.1016/j.ijid.2020.04.019.Peer-Reviewed Original ResearchConceptsHBV exposureHepatitis B virus infectionHCV/HBVIncidence of HBVHBV serological markersB virus infectionCross-sectional studyGenotypes/subtypesHBV infectionCohort studySerological markersHBV isolatesMulticenter studyHigh prevalenceLower incidenceVirus infectionHigh riskHBVNew casesBlood collectionFemale prisonersInfectionIncidencePreventive measuresPrevalenceEffect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapyGenomic and Epidemiological Surveillance of Zika Virus in the Amazon Region
Giovanetti M, Faria N, Lourenço J, de Jesus J, Xavier J, Claro I, Kraemer M, Fonseca V, Dellicour S, Thézé J, da Silva Salles F, Gräf T, Silveira P, do Nascimento V, de Souza V, de Melo Iani F, Castilho-Martins E, Cruz L, Wallau G, Fabri A, Levy F, Quick J, de Azevedo V, Aguiar R, de Oliveira T, de Menezes C, da Costa Castilho M, Terra T, da Silva M, de Filippis A, de Abreu A, Oliveira W, Croda J, de Albuquerque C, Nunes M, Sabino E, Loman N, Naveca F, Pybus O, Alcantara L. Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region. Cell Reports 2020, 30: 2275-2283.e7. PMID: 32075736, DOI: 10.1016/j.celrep.2020.01.085.Peer-Reviewed Original Research
2019
Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine
Murugesan K, Hogan C, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M, Cattamanchi A, Pinsky B, Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. Journal Of Clinical Microbiology 2019, 57: 10.1128/jcm.00782-19. PMID: 31511335, PMCID: PMC6813001, DOI: 10.1128/jcm.00782-19.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell-free DNABlood collection tubesUrine samplesLower medianPCR cycle thresholdCollection tubesEDTA blood samplesTB patientsTuberculosis patientsUrine volumeHealthy donorsBlood samplesAttractive biomarkerEDTA tubesPatient samplesBloodWhole urineThawed plasmaUrineUrine preservativeCycle thresholdMedianPatientsPreanalytical factorsHigh level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage
Weis-Torres S, Fitts S, Cardoso W, Higa Junior M, Lima L, Bandeira L, Castro V, Carneiro F, Iglecias L, Cesar G, Tanaka T, Puga M, Rezende G, Croda J, Lago B, Motta-Castro A. High level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage. International Journal Of Infectious Diseases 2019, 90: 46-52. PMID: 31589921, DOI: 10.1016/j.ijid.2019.09.029.Peer-Reviewed Original ResearchConceptsLow endemic areasHBV infectionHBV exposureEndemic areasHepatitis B virus infectionHIV serological markersB virus infectionHistory of surgeryHBV transmissionHBV vaccinationHBV vaccineHepatitis BChronic carriersSerological markersVaccination coverageHomosexual contactVirus infectionPrevalence ratesSusceptible adultsAge 18InfectionVulnerable populationsDisadvantaged populationsVaccinationMolecular featuresGenetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Tatara M, Perdigão J, Viveiros M, Kritski A, Silva K, Sacchi F, de Lima C, Dos Santos P, Diniz J, Almeida Silva P, Gomes P, Gomes M, Cunha E, Lapa E Silva J, Portugal I, Croda J, Andrade M. Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil. American Journal Of Tropical Medicine And Hygiene 2019, 101: 774-779. PMID: 31392954, PMCID: PMC6779181, DOI: 10.4269/ajtmh.19-0324.Peer-Reviewed Original ResearchConceptsPopulation-based prospective studyDrug resistanceMolecular epidemiologyResistance profilesRepetitive units-variable numberMTB/RIFDrug susceptibility testDrug resistance profilesTransmission of MtbPublic health policyPhenotypic resistance profilesIsoniazid monoTB preventionProspective studyNew strain typesTB epidemiologyPrimary resistanceHigh prevalenceMTB isolatesProportion methodHealth policyMycobacterium tuberculosisSusceptibility testsTuberculosisVulnerable populationsScreening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
Puga M, Bandeira L, Pompilio M, de Rezende G, Soares L, de Castro V, Tanaka T, Cesar G, de Oliveira S, Teles S, Yassuda R, dos Santos Weis-Torres S, Basílio S, Croda J, Motta-Castro A. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required. PLOS ONE 2019, 14: e0221265. PMID: 31437184, PMCID: PMC6705821, DOI: 10.1371/journal.pone.0221265.Peer-Reviewed Original ResearchConceptsHepatitis B virusSyphilis infectionViral hepatitisHIV infectionB virusAnti-HCV positive samplesChronic hepatitis B virusFirst-line anti-tuberculosis drugsLifetime syphilis infectionCases of tuberculosisAnti-TB drugsCross-sectional studyPublic health problemAnti-tuberculosis drugsCurrent HCVHCV exposureHCV RNAHepatitis testingTuberculosis infectionActive syphilisSerological markersEpidemiological featuresFrequent causeSide effectsHCVSafety and costs of blood transfusion practices in dengue cases in Brazil
Machado A, Negrão F, Croda J, de Medeiros E, dos Santos Pires M. Safety and costs of blood transfusion practices in dengue cases in Brazil. PLOS ONE 2019, 14: e0219287. PMID: 31283788, PMCID: PMC6613682, DOI: 10.1371/journal.pone.0219287.Peer-Reviewed Original ResearchConceptsHospital stayHospitalization timeHospitalisation timeWHO criteriaBlood transfusion componentsCost of hospitalisationWorld Health Organization recommendationsProspective observational studyBlood transfusion practicesPublic health problemTransfused groupBlood transfusionHospitalisation costsTransfusion practiceMedical recordsObservational studyTransfusion componentsWHO recommendationsPatientsTransfusionHealth problemsBlood componentsDengue casesStayHospitalisationPaediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies
Martinez L, Lo N, Cords O, Hill P, Khan P, Hatherill M, Mandalakas A, Kay A, Croda J, Horsburgh C, Zar H, Andrews J. Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies. The Lancet Respiratory Medicine 2019, 7: 544-552. PMID: 31078497, PMCID: PMC7323920, DOI: 10.1016/s2213-2600(19)30137-7.Peer-Reviewed Original ResearchConceptsM tuberculosis transmissionHousehold contact tracingTuberculosis transmissionFuture public health strategiesContact tracingGlobal tuberculosis control effortsAdult tuberculosis casesPaediatric tuberculosis infectionMycobacterium tuberculosis transmissionHigh-burden settingsTuberculosis control effortsEffective public health responsePopulation attributable fractionPublic health strategiesAge 5 yearsCommunity-based interventionsPublic health interventionsPublic health responsePediatric transmissionChildhood tuberculosisTuberculosis infectionTuberculosis casesActive surveillanceHealth strategiesHousehold exposure