Featured Publications
Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model.
Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.Peer-Reviewed Original ResearchConceptsCortical circuitsCognitive deficitsCortical circuit modelAltered excitation-inhibition balanceExcitatory pyramidal neuronsNMDA receptor hypofunctionCerebral cortical circuitsExcitation-inhibition balancePyramidal neuronsReceptor hypofunctionDistinct time coursesSynaptic excitationInhibitory interneuronsMultiple neuropsychiatric disordersBehavioral deficitsSynaptic balanceSynaptic levelLatest evidenceNeuropsychiatric disordersCognitive functionCircuit mechanismsBehavioral effectsPsychometric performanceBehavioral levelTask paradigmGeometry of neural computation unifies working memory and planning
Ehrlich DB, Murray JD. Geometry of neural computation unifies working memory and planning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2115610119. PMID: 36067286, PMCID: PMC9478653, DOI: 10.1073/pnas.2115610119.Peer-Reviewed Original ResearchConceptsNeural dataPossible circuit mechanismReal-world tasksMemory taskUpcoming eventsSensory modelPrefrontal cortexCognitive functionRecurrent neural networkHuman behaviorNeurophysiological observationsMemoryCircuit mechanismsFalsifiable predictionsFuture behaviorTaskModular processRepresentational strategiesRepresentationNeural networkCortexBehaviorDistinct typesBrainFindings
2022
A Dynamical Systems Perspective on Thalamic Circuit Function
Gu Q, Murray J. A Dynamical Systems Perspective on Thalamic Circuit Function. 2022, 401-415. DOI: 10.1017/9781108674287.022.Peer-Reviewed Original Research