2003
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking JD, Taylor GA, McKinney JD. Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47. Science 2003, 302: 654-659. PMID: 14576437, DOI: 10.1126/science.1088063.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedComputational BiologyDisease SusceptibilityFemaleGTP PhosphohydrolasesGTP-Binding ProteinsHydrogen-Ion ConcentrationImmunity, InnateInterferon-gammaMacrophage ActivationMacrophagesMacrophages, AlveolarMaleMiceMice, Inbred C57BLMutationMycobacterium tuberculosisNitric Oxide SynthaseNitric Oxide Synthase Type IIOligonucleotide Array Sequence AnalysisPhagosomesReverse Transcriptase Polymerase Chain ReactionSignal TransductionTuberculosisConceptsNitric oxide synthase 2LRG-47Principal effector mechanismDefective bacterial killingImmune controlEffector mechanismsMtb replicationImpaired maturationBacterial killingIntracellular pathogensMycobacterium tuberculosisHost macrophagesInfected host macrophagesSynthase 2TuberculosisIRG-47MtbIFNDiseaseMiceMacrophages
1997
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking J, Xie Q, Nathan C. NITRIC OXIDE AND MACROPHAGE FUNCTION. Annual Review Of Immunology 1997, 15: 323-350. PMID: 9143691, DOI: 10.1146/annurev.immunol.15.1.323.ChaptersConceptsExpression of NOS2Nitric oxide synthaseAdaptive immune systemNormal host cellsRemarkable molecular machinesInflammatory diseasesLymphocyte proliferationNO pathwayOxide synthaseImmune responseMacrophage productsMacrophage functionSuppressive effectImmune systemNOS2Nitric oxideHigh-output isoformTumor cellsMacrophagesCytotoxic actionElevated Ca2Transcriptional inductionFunctional dimerCytotoxic activityMolecular machines
1993
Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Karupiah G, Xie Q, Buller R, Nathan C, Duarte C, MacMicking J. Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase. Science 1993, 261: 1445-1448. PMID: 7690156, DOI: 10.1126/science.7690156.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid OxidoreductasesAnimalsArginineCell LineCells, CulturedEctromelia virusEctromelia, InfectiousEnzyme InductionFemaleHumansInterferon-gammaMacrophagesMiceMice, Inbred C57BLNitric OxideNitric Oxide SynthaseOmega-N-MethylarginineSimplexvirusTransfectionVaccinia virusVirus ReplicationConceptsViral replicationIFN-gammaHerpes simplex-1 virusNitric oxideDetectable NO synthesisSubstantial antiviral effectEctromelia virus infectionNitric oxide synthaseInducible NO synthaseIFN-gamma-treated macrophagesOxide synthaseAntiviral effectVirus infectionNO synthaseNO synthesisAntiviral activityInterferonEpithelial cellsMouse macrophagesCell productionMacrophagesCell typesSynthaseInhibitors