1996
Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate
Deutch A, Lewis D, Whitehead R, Elsworth J, Iadarola M, Redmond D, Roth R. Effects of D2 dopamine receptor antagonists on fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse 1996, 23: 182-191. PMID: 8807746, DOI: 10.1002/(sici)1098-2396(199607)23:3<182::aid-syn7>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsFos-LI neuronsExtrapyramidal side effectsEffective antipsychotic drugAntipsychotic drugsEntorhinal cortexSide effectsReceptor antagonistFos expressionD2 receptorsCaudate nucleusNucleus accumbensTemporal cortexFos-like immunoreactive neuronsExtra-pyramidal side effectsD2 dopamine receptor antagonistRat striatal complexC-fosD2 receptor antagonismDorsolateral caudate nucleusDopamine receptor antagonistEffect of administrationImmediate early gene c-fosD2 receptor antagonistEarly gene c-fosFos protein expressionBlockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966
Horger B, Elsworth J, Roth R. Blockade of FG 7142‐Induced Increased Dopamine Utilization by the Glycine/NMDA Receptor Antagonist (+)‐HA 966. Journal Of Neurochemistry 1996, 66: 1959-1962. PMID: 8780023, DOI: 10.1046/j.1471-4159.1996.66051959.x.Peer-Reviewed Original ResearchConceptsDopamine utilizationFG 7142Medial prefrontal cortexNucleus accumbensPrefrontal cortexReceptor antagonistHA-966Shell subdivisionReceptor influencesBenzodiazepine inverse agonist FG 7142Male Sprague-Dawley ratsMedia prefrontal cortexMesoaccumbal dopamine neuronsGlycine/NMDA receptor antagonistGlycine receptor antagonistSaline 15 minNMDA receptor antagonistSprague-Dawley ratsDopamine neuronsVehicle administrationSystemic administrationDihydroxyphenylacetic acidAccumbensMajor metaboliteTissue concentrations
1991
The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys
Lawrence M, Redmond D, Elsworth J, Taylor J, Roth R. The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys. Life Sciences 1991, 49: pl229-pl234. PMID: 1836030, DOI: 10.1016/0024-3205(91)90299-q.Peer-Reviewed Original ResearchConceptsSCH 23390African green monkeysD1 antagonistHealthy African green monkeysGreen monkeysParkinsonian side effectsD1 receptor antagonistPoverty of movementSigns of parkinsonismSelective D1 antagonistFull D1 agonistParkinsonian signsReceptor antagonistD1 agonistD1 receptorsSystemic administrationParkinson's diseasePsychiatric disordersSide effectsMotor changesClinical useParkinsonismAntagonistBlink rateMonkeys
1986
Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding
Elsworth J, Dewar D, Glover V, Goodwin B, Clow A, Sandler M. Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal Of Neural Transmission 1986, 67: 45-56. PMID: 3023548, DOI: 10.1007/bf01243358.Peer-Reviewed Original ResearchConceptsRo-15 1788Benzodiazepine receptor antagonistBenzodiazepine receptor agonistsBenzodiazepine receptor bindingPeripheral benzodiazepine receptor ligandsBenzodiazepine receptor ligandsReceptor antagonistPeripheral receptorsReceptor agonistReceptor bindingEndogenous inhibitorMonoamine oxidaseReceptor ligandsRat liverMAO ATyramine oxidationHuman urineLow molecular weight fractionThin-layer chromatographyTribulinAgonistsAntagonistGABABenzodiazepinesLiver