Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress
Elsworth J, Morrow B, Roth R. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse 2001, 42: 80-83. PMID: 11574943, DOI: 10.1002/syn.1102.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposurePrefrontal cortexCocaine exposureShort-term memory deficitsVentromedial prefrontal cortexShort-term memoryMedial prefrontal cortexDopamine neuronsAdolescent ratsCognitive deficitsMemory deficitsMesoprefrontal dopamine systemPrenatal cocaineMild footshock stressDopamine systemDeficitsFootshock stressNeurobehavioral deficitsDopamine turnoverIntravenous modelRodent modelsBehavioral abnormalitiesFetal developmentMild stressCortexPrenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress
Morrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.Peer-Reviewed Original ResearchConceptsA10 dopamine neuronsDopamine neuronsDopaminergic neuronsPrenatal exposurePrenatal saline controlsTyrosine hydroxylase immunoreactiveA10 dopaminergic neuronsCocaine-induced reductionRat dopaminergic neuronsCocaine-exposed ratsPoor cognitive performanceYoung adult offspringUnderlying biochemical changesDopaminergic functionA9 regionSaline controlsIntravenous modelPerinatal lossAdult offspringIntermittent footshockImmediate early genesCognitive deficitsNeuronal systemsBehavioral effectsCell groups