1991
The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys
Lawrence M, Redmond D, Elsworth J, Taylor J, Roth R. The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys. Life Sciences 1991, 49: pl229-pl234. PMID: 1836030, DOI: 10.1016/0024-3205(91)90299-q.Peer-Reviewed Original ResearchConceptsSCH 23390African green monkeysD1 antagonistHealthy African green monkeysGreen monkeysParkinsonian side effectsD1 receptor antagonistPoverty of movementSigns of parkinsonismSelective D1 antagonistFull D1 agonistParkinsonian signsReceptor antagonistD1 agonistD1 receptorsSystemic administrationParkinson's diseasePsychiatric disordersSide effectsMotor changesClinical useParkinsonismAntagonistBlink rateMonkeys
1986
Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding
Elsworth J, Dewar D, Glover V, Goodwin B, Clow A, Sandler M. Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal Of Neural Transmission 1986, 67: 45-56. PMID: 3023548, DOI: 10.1007/bf01243358.Peer-Reviewed Original ResearchConceptsRo-15 1788Benzodiazepine receptor antagonistBenzodiazepine receptor agonistsBenzodiazepine receptor bindingPeripheral benzodiazepine receptor ligandsBenzodiazepine receptor ligandsReceptor antagonistPeripheral receptorsReceptor agonistReceptor bindingEndogenous inhibitorMonoamine oxidaseReceptor ligandsRat liverMAO ATyramine oxidationHuman urineLow molecular weight fractionThin-layer chromatographyTribulinAgonistsAntagonistGABABenzodiazepinesLiver