2001
Myocardial Revascularization as a Therapeutic Strategy in the Patient with Advanced Ventricular Dysfunction
Mitropoulos F, Elefteriades J. Myocardial Revascularization as a Therapeutic Strategy in the Patient with Advanced Ventricular Dysfunction. Heart Failure Reviews 2001, 6: 163-175. PMID: 11391034, DOI: 10.1023/a:1011416929501.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassCoronary DiseaseFemaleHumansMalePatient SelectionPerioperative CareTime FactorsTreatment OutcomeVentricular DysfunctionConceptsCoronary artery bypassVentricular dysfunctionArtery bypassPerioperative managementEjection fractionPatient selectionAdvanced ventricular dysfunctionRight ventricular dysfunctionLeft ventricular dysfunctionLow ejection fractionOptimal perioperative managementSevere ventricular dysfunctionCareful patient selectionCoronary artery diseaseLong-term outcomesNumber of patientsQuality of lifeSurgical revascularizationHeart transplantationPulmonary hypertensionMyocardial revascularizationOverall prognosisArtery diseaseMedical managementRedo bypassSingle-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆
Kim R, Mariconda D, Tellides G, Kopf G, Dewar M, Lin Z, Elefteriades J. Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆. European Journal Of Cardio-Thoracic Surgery 2001, 20: 127-132. PMID: 11423285, DOI: 10.1016/s1010-7940(01)00765-5.Peer-Reviewed Original ResearchConceptsSingle-clamp techniqueCoronary artery bypassPostoperative strokeArtery bypassStroke preventionCerebrovascular accidentSide-biting aortic clampAdverse myocardial effectsCross-clamp timePostoperative adverse eventsPerioperative myocardial infarctionCoronary bypass operationsLogistic regression analysisEmbolic consequencesHospital mortalityAdverse eventsAortic clampMyocardial effectsBypass operationMyocardial infarctionMyocardial protectionClinical practiceClamp techniqueSecond surgeonStroke
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptoms
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashionFailure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome
Samady H, Elefteriades J, Abbott B, Mattera J, McPherson C, Wackers F. Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome. Circulation 1999, 100: 1298-1304. PMID: 10491374, DOI: 10.1161/01.cir.100.12.1298.Peer-Reviewed Original ResearchConceptsVentricular functionIschemic cardiomyopathyGroup AHeart failure scoreLeft ventricular functionIschemic LV dysfunctionPoor patient outcomesB. Group ALack of improvementBaseline LVEFEffective revascularizationImproved LVEFCoronary revascularizationLV dysfunctionConsecutive patientsIntraoperative variablesPostoperative improvementCardiac deathLV functionPoor outcomeViable myocardiumLVEF assessmentIschemic myocardiumPatient outcomesWorse outcomes
1998
Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting?
Mehta I, Weinberg J, Jones M, Tellides G, Kopf G, Shaw R, Zaret B, Elefteriades J. Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting? The Annals Of Thoracic Surgery 1998, 65: 17-23. PMID: 9456088, DOI: 10.1016/s0003-4975(97)01192-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary Artery BypassFemaleHumansMaleMiddle AgedRadiographyRecurrenceReoperationSaphenous VeinSurvival RateVascular PatencyConceptsSaphenous vein graftsVein graftsRedo CABGDisease-free graftsNR groupRedo Coronary Artery Bypass GraftingR groupCoronary Artery Bypass GraftingRedo coronary artery bypassGood late survivalArtery Bypass GraftingCoronary artery bypassLate myocardial infarctionFirst CABGRecurrent anginaRedo revascularizationArtery bypassBypass GraftingOperative mortalitySurgical mortalityAngiographic evaluationCardiac hospitalizationConsecutive patientsNew stenosisRandomized studyTopical Hypothermia: Ineffective and Deleterious as Adjunct to Cardioplegia for Myocardial Protection
Nikas D, Ramadan F, Elefteriades J. Topical Hypothermia: Ineffective and Deleterious as Adjunct to Cardioplegia for Myocardial Protection. The Annals Of Thoracic Surgery 1998, 65: 28-31. PMID: 9456090, DOI: 10.1016/s0003-4975(97)01261-7.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery BypassFemaleHeart Arrest, InducedHumansHypothermia, InducedLung DiseasesMaleMiddle AgedParalysisPhrenic NervePostoperative ComplicationsConceptsCold blood cardioplegiaFirst postoperative dayTopical hypothermiaPostoperative dayPulmonary complicationsDiaphragmatic paralysisSystemic hypothermiaBlood cardioplegiaGroup AGroup BIced slushMyocardial protectionIntermittent cold blood cardioplegiaGroup B. Group AAdditional cardioprotective benefitNonrandomized consecutive patientsPhrenic nerve paralysisPostoperative cardiac morbidityCoronary artery bypassLow cardiac outputPerioperative myocardial infarctionCoronary bypass patientsB. Group ASignificant differencesInotrope use
1997
The “pro” point of view
Elefteriades J. The “pro” point of view. Journal Of Cardiothoracic And Vascular Anesthesia 1997, 11: 661-668. PMID: 9263104, DOI: 10.1016/s1053-0770(97)90023-9.Peer-Reviewed Original ResearchResults of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%
Elefteriades J, Morales D, Gradel C, Tollis G, Levi E, Zaret B. Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%. The American Journal Of Cardiology 1997, 79: 1573-1578. PMID: 9202343, DOI: 10.1016/s0002-9149(97)00201-4.Peer-Reviewed Original ResearchConceptsAdvanced LV dysfunctionInternal mammary arteryCoronary artery diseaseEjection fractionLV dysfunctionMammary arteryArtery diseaseCongestive heart failure classSevere left ventricular dysfunctionCoronary Artery Bypass GraftingBetter long-term survivalHeart failure classSingle surgeon's patientsArtery Bypass GraftingCoronary artery bypassHigh operative riskLeft ventricular dysfunctionSevere ventricular arrhythmiasLV ejection fractionVentricular ejection fractionUse of CABGLong-term survivalQuality of lifeAngina classArtery bypass
1995
Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction.
Braxton J, Hammond G, Letsou G, Franco K, Kopf G, Elefteriades J, Baldwin J. Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction. Circulation 1995, 92: ii66-8. PMID: 7586463, DOI: 10.1161/01.cir.92.9.66.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAcute myocardial infarctionQ-wave infarctionArtery bypass graft surgeryNon-Q-wave infarctionBypass graft surgeryMyocardial infarctionGraft surgeryControl groupNon-Q-wave myocardial infarctionIntra-aortic balloon pumpOptimal timingGroup 1 patientsNeed of vasopressorsPerioperative myocardial infarctionWeeks of infarctionAngina refractoryPerioperative MIHospital mortalitySurgical mortalityBalloon pumpControl patientsMedical managementRelative riskHigh riskCabg in Advanced Left Ventricular Dysfunction
Elefteriades J, Kron I. Cabg in Advanced Left Ventricular Dysfunction. Cardiology Clinics 1995, 13: 35-42. PMID: 7796430, DOI: 10.1016/s0733-8651(18)30060-2.Peer-Reviewed Original ResearchConceptsAdvanced left ventricular dysfunctionCongestive heart failure stateAdvanced ischemic cardiomyopathyEjection fraction increaseIndependent clinical seriesInternal mammary conduitsHeart failure stateLeft ventricular dysfunctionHeart transplantationVentricular dysfunctionIschemic cardiomyopathyPatient groupClinical seriesIschemic muscleCABGPatientsLong-term longevityMuscleUniversity of VirginiaTransplantationCardiomyopathyDysfunctionImportant roleSynthesis Guidelines for Selection Among Treatment Options
Elefteriades J, Letsou G, Lee F. Synthesis Guidelines for Selection Among Treatment Options. Cardiology Clinics 1995, 13: 137-143. PMID: 7796428, DOI: 10.1016/s0733-8651(18)30070-5.Peer-Reviewed Original Research
1993
Coronary artery bypass grafting in severe left ventricular dysfunction: Excellent survival with improved ejection fraction and functional state
Elefteriades J, Tolis G, Levi E, Mills L, Zaret B. Coronary artery bypass grafting in severe left ventricular dysfunction: Excellent survival with improved ejection fraction and functional state. Journal Of The American College Of Cardiology 1993, 22: 1411-1417. PMID: 8227799, DOI: 10.1016/0735-1097(93)90551-b.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdultAgedAged, 80 and overCause of DeathCoronary Artery BypassDefibrillators, ImplantableFemaleFollow-Up StudiesHeart DiseasesHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMammary ArteriesMiddle AgedPrognosisQuality of LifeSeverity of Illness IndexStroke VolumeSurvival RateVentricular Function, LeftConceptsCoronary Artery Bypass GraftingArtery Bypass GraftingCoronary artery bypassSevere left ventricular dysfunctionLeft ventricular ejection fractionInternal mammary arteryLeft ventricular dysfunctionVentricular ejection fractionEjection fractionArtery bypassVentricular dysfunctionBypass GraftingMammary arteryMortality rateCanadian Cardiovascular Society angina classCongestive heart failure classGood medium-term survivalAdvanced ischemic cardiomyopathyAdvanced ventricular dysfunctionHeart failure classImproved ejection fractionHospital mortality rateCongestive heart failureIntraaortic balloon pumpSignificant ventricular arrhythmiasTransesophageal two-dimensional echocardiographic analysis of right ventricular systolic performance indices during coronary artery bypass grafting
Rafferty T, Durkin M, Harris S, Elefteriades J, Hines R, Prokop E, O'Connor T. Transesophageal two-dimensional echocardiographic analysis of right ventricular systolic performance indices during coronary artery bypass grafting. Journal Of Cardiothoracic And Vascular Anesthesia 1993, 7: 160-166. PMID: 8477020, DOI: 10.1016/1053-0770(93)90210-c.Peer-Reviewed Original ResearchConceptsEnd-diastolic volume indexPulmonary artery pressureEnd-diastolic pressureCardiopulmonary bypassCardiac indexRV end-diastolic volume indexSignificant right coronary artery diseaseCoronary artery bypass surgeryRight coronary artery diseaseRV end-diastolic pressurePost-CPB valuesArtery bypass surgeryCoronary artery bypassCoronary artery diseaseMin/m2Two-dimensional echocardiographic analysisML/m2Inotropic supportIntraoperative courseArtery bypassArtery pressureBypass surgeryNitroglycerin infusionArtery diseaseEjection fractionThe relationship between “Normal” transesophageal color-flow doppler-defined tricuspid regurgitation and thermodilution right ventricular ejection fraction measurements
Rafferty T, Durkin M, Hines R, Elefteriades J, O'Connor T. The relationship between “Normal” transesophageal color-flow doppler-defined tricuspid regurgitation and thermodilution right ventricular ejection fraction measurements. Journal Of Cardiothoracic And Vascular Anesthesia 1993, 7: 167-174. PMID: 8477021, DOI: 10.1016/1053-0770(93)90211-3.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationEjection fractionRight ventricular ejection fraction measurementsThermodilution right ventricular ejection fractionRight atrial pressure waveformTricuspid regurgitation jet areaRight ventricular ejection fractionVentricular ejection fraction measurementsRight ventricular functionVentricular ejection fractionJet areaEjection fraction measurementsRevascularization patientsChest closureCardiopulmonary bypassVentricular functionAtrial areaEndotracheal intubationTricuspid valveRegurgitation indexRegurgitationWaveform abnormalitiesExcursion ratioPressure waveformRegression analysis
1992
Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery
RAFFERTY T, DURKIN M, HINES R, ELEFTERIADES J, HARRIS S, O'CONNOR T. Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery. Critical Care Medicine 1992, 20: 1524-1528. PMID: 1424694, DOI: 10.1097/00003246-199211000-00008.Peer-Reviewed Original ResearchConceptsRight ventricular systolic performanceVentricular systolic performanceHeart rateCardiac indexSystolic performanceRight ventricular end-diastolic volume indexRight ventricular ejection fraction measurementsCoronary artery bypass graft surgeryVentricular end-diastolic volume indexCoronary artery bypass graft patientsArtery bypass graft surgeryEnd-diastolic volume indexRight ventricular ejection fractionVentricular ejection fraction measurementsBypass graft surgeryBypass graft patientsVentricular ejection fractionRight atrial areaEjection fraction measurementsGraft patientsGraft surgeryDiastolic diameterEjection fractionAtrial areaProspective studyTransesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent
Rafferty T, Durkin M, Elefteriades J, O’Connor T. Transesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent. Journal Of Thoracic And Cardiovascular Surgery 1992, 104: 637-641. PMID: 1513154, DOI: 10.1016/s0022-5223(19)34729-4.Peer-Reviewed Original ResearchConceptsCrystalloid cardioplegic solutionCardioplegic solutionValve dysfunctionValve integrityEchocardiographic contrast agentsImaging agentVentricular dimensional changesAortic regurgitationEchocardiographic evaluationLeft atriumCardiac dimensionsIntravascular injectionSolution administrationPatientsDysfunctionContrast agentsAgentsEchocardiographyRegurgitationAtriumAdministrationStrategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience
GEHA A, ELEFTERIADES J, HSU J, BIBLO L, HOCH D, BATSFORD W, ROSENFELD L, CARLSON M, JOHNSON N, WALDO A. Strategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience. Annals Of Surgery 1992, 216: 309-317. PMID: 1417180, PMCID: PMC1242614, DOI: 10.1097/00000658-199209000-00010.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorSubendocardial resectionVentricular tachycardiaSurgical treatmentLV aneurysmSudden deathThirty-day mortality rateSevere LV dysfunctionCongestive heart failureRecurrent ventricular tachycardiaSignificant myocardial ischemiaLong-term survivorsMalignant ventricular arrhythmiasMalignant ventricular tachyarrhythmiasCent of survivorsImplantable cardioverter defibrillatorLong-term survivalActuarial survivalAntiarrhythmic medicationsLate deathsComparable patientsLV dysfunctionConsecutive patientsHeart failureVentricular arrhythmias
1990
Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias
Elefteriades J, Biblo L, Batsford W, Rosenfeld L, Henthorn R, Carlson M, Waldo A, Hsu J, Geha A. Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias. The Annals Of Thoracic Surgery 1990, 49: 94-100. PMID: 2297279, DOI: 10.1016/0003-4975(90)90362-a.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorResection groupThirty-day mortalityCoronary artery bypassMalignant ventricular tachyarrhythmiasIntractable ventricular arrhythmiasImplantable cardioverter defibrillatorAICD placementArtery bypassSurgical treatmentEndocardial resectionVentricular arrhythmiasVentricular tachyarrhythmiasAntiarrhythmic agentsSudden deathCardioverter defibrillatorResectionMortality figuresPatientsEffective interventionsGreatest overall benefitSurvivalGroupOverall benefitValuable alternative
1988
Recovery of severe ischemic ventricular dysfunction after coronary artery bypass grafting
Brill D, Deckelbaum L, Remetz M, Soufer R, Elefteriades J, Zaret B. Recovery of severe ischemic ventricular dysfunction after coronary artery bypass grafting. The American Journal Of Cardiology 1988, 61: 650-651. PMID: 3257840, DOI: 10.1016/0002-9149(88)90784-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoronary Artery BypassCoronary DiseaseHeartHeart VentriclesHumansMaleMyocardial ContractionStroke VolumeConceptsWall motion abnormalitiesVentricular dysfunctionLeft ventricularMotion abnormalitiesReversible wall motion abnormalitiesSevere coronary artery diseaseVentricular wall motion abnormalitiesIschemic ventricular dysfunctionReversible ventricular dysfunctionCoronary artery bypassCoronary artery diseasePeriod of ischemiaArtery bypassIschemic dysfunctionArtery diseaseHibernating myocardiumMyocardial infarctionMyocardial scarDysfunctionFibrous tissueRecent evidencePatientsComplete reversalAbnormalitiesRevascularization