2016
Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3
Becquey E, Ouédraogo C, Hess S, Rouamba N, Prince L, Ouédraogo J, Vosti S, Brown K. Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3. Journal Of Nutrition 2016, 146: 2058-2066. PMID: 27489011, DOI: 10.3945/jn.116.230128.Peer-Reviewed Original ResearchMeSH KeywordsBurkina FasoChild, PreschoolCluster AnalysisDiarrheaDietary SupplementsDose-Response Relationship, DrugFeverFollow-Up StudiesGrowth DisordersHumansIncidenceInfantMalariaMorbidityPrevalenceRural PopulationZincConceptsTherapeutic zinc supplementationPreventive zinc supplementationZinc supplementationNonintervention controlsMalaria incidenceDiarrhea incidenceZinc-deficient populationsPrevalence of diarrheaPlasma zinc concentrationTreatment of diarrheaPrimary outcomeBurkinabe childrenMSC groupLower incidenceNIC groupStudy groupTreatment groupsPrimary analysisControl groupDiarrheaIncidenceSupplementationTrial 1Young childrenFever
2015
Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial
Abbeddou S, Hess S, Yakes Jimenez E, Somé J, Vosti S, Guissou R, Ouédraogo J, Brown K. Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial. Maternal And Child Nutrition 2015, 11: 90-104. PMID: 25521188, PMCID: PMC6860357, DOI: 10.1111/mcn.12162.Peer-Reviewed Original ResearchMeSH KeywordsBurkina FasoDietary FatsDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodHumansInfantLogistic ModelsPatient ComplianceRural PopulationSocioeconomic FactorsTabletsZincConceptsSmall-quantity lipid-based nutrient supplementsPlasma zinc concentrationDispersible tabletsLipid-based nutrient supplementsCaregiver-reported adherenceMonths of supplementationDisappearance rateMonths of ageSubgroup of childrenWeekly adherenceIntervention trialsClinical trialsLow adherenceSupplementation trialAdherence dataHome visitsCaregiver interviewsZinc tabletsLack of changeChildren 11Zinc concentrationsStudy outcomesObservation periodAdherenceMonths
2010
Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso
Hess S, Bado L, Aaron G, Ouédraogo J, Zeilani M, Brown K. Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso. Maternal And Child Nutrition 2010, 7: 357-367. PMID: 21159124, PMCID: PMC6860760, DOI: 10.1111/j.1740-8709.2010.00287.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBurkina FasoConsumer BehaviorDietary FatsDietary SupplementsDose-Response Relationship, DrugFemaleFocus GroupsHumansInfantInfant FoodInfant Nutritional Physiological PhenomenaInterviews as TopicMaleMicronutrientsNutritive ValueSocioeconomic FactorsSurveys and QuestionnairesYoung AdultZincConceptsLipid-based nutrient supplementsAcceptability studyYoung childrenPublic health concernPossible adverse effectsNutrient supplementsNutritional statusComplementary foodsChildren 9Health concernLow-income countriesMaternal reportsAdverse effectsTrialsChildren's consumptionMicronutrient deficienciesMothersChildrenGood acceptabilityDoseDetectable differenceTime of consumptionSupplementsNovel strategyDetection of differences
2007
Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa
Parikh S, Ouedraogo J, Goldstein JA, Rosenthal PJ, Kroetz DL. Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa. Clinical Pharmacology & Therapeutics 2007, 82: 197-203. PMID: 17361129, DOI: 10.1038/sj.clpt.6100122.Peer-Reviewed Original ResearchMeSH KeywordsAlkynesAmodiaquineAntimalarialsAryl Hydrocarbon HydroxylasesBenzoxazinesBurkina FasoChromatography, High Pressure LiquidCyclopropanesCytochrome P-450 CYP2C8Dose-Response Relationship, DrugDrug InteractionsEnzyme InhibitorsGenotypeHIV Protease InhibitorsHumansLopinavirMalaria, FalciparumModels, BiologicalPolymorphism, GeneticPyridinesPyrimidinonesPyronesReverse Transcriptase InhibitorsSaquinavirSpectrophotometry, UltravioletSulfonamidesTreatment OutcomeTrimethoprimConceptsAntimalarial drug amodiaquineMalaria-infected patientsAntiretroviral drug efavirenzImportant clinical implicationsAmodiaquine metabolismCYP2C8 genotypeMalaria treatmentN-desethylamodiaquineCYP2C8 variantsCYP2C8 activityCYP2C8 inhibitorsDrug interactionsDefective metabolismClinical implicationsCYP2C8Common polymorphismsDrug efavirenzMetabolismRelevant concentrationsDrugsEfficacyPrimary metabolitesAllele frequenciesToxicitySample size