2024
Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes
Nikolakopoulos I, Liu Y, Sinusas A, Miller E, Feher A. Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.099. DOI: 10.1093/ehjci/jeae142.099.Peer-Reviewed Original ResearchPositron emission tomographyMyocardial flow reserveCoronary artery diseaseCardiovascular outcomesArtery diseaseFlow reserveEvaluation of coronary artery diseaseHistory of heart transplantationMedian interval timeKaplan-Meier methodPredictive of cardiovascular outcomesLong-term outcomesPerioperative risk stratificationCoronary bloodChest painHeart transplantationRisk stratificationSerial examsCox regressionMyocardial infarctionInterquartile rangeC-statisticEmission tomographyPatientsContinuous variables
2023
Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original ResearchIntravascular imaging-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionPercutaneous coronary interventionOptical coherence tomographyMyocardial infarctionIntravascular ultrasoundCoronary interventionIntravascular imagingIVUS-guided percutaneous coronary interventionCoherence tomographyNumber of PCIsNational Inpatient SampleMultivariable logistic regressionCochran-Armitage trend testIVUS useHospital mortalityClinical outcomesOCT guidanceInpatient SampleImproved outcomesLower oddsLower mortalityLogistic regressionContinuous outcomesOutcomes
2022
A Systematic Review and Meta-Analysis of Clinical Outcomes of Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention.
Simsek B, Kostantinis S, Karacsonyi J, Alaswad K, Megaly M, Karmpaliotis D, Masoumi A, Jaber W, Nicholson W, Rinfret S, Mashayekhi K, Werner G, McEntegart M, Lee S, Khatri J, Harding S, Avran A, Jaffer F, Doshi D, Kao H, Sianos G, Yamane M, Milkas A, Azzalini L, Garbo R, Tammam K, Abi Rafeh N, Nikolakopoulos I, Vemmou E, Rangan B, Burke M, Garcia S, Croce K, Wu E, Tsuchikane E, Di Mario C, Galassi A, Gagnor A, Knaapen P, Jang Y, Kim B, Poommipanit P, Brilakis E. A Systematic Review and Meta-Analysis of Clinical Outcomes of Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention. Journal Of Invasive Cardiology 2022, 34: e763-e775. PMID: 36227013.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionSubsequent clinical outcomesClinical outcomesCTO-PCIObservational studyMyocardial infarctionCause mortalityCoronary interventionOdds ratioSubsequent coronary artery bypass surgerySystematic reviewCoronary artery bypass surgeryAdverse cardiovascular eventsHeart failure hospitalizationTarget vessel revascularizationArtery bypass surgeryBetter clinical outcomesConfidence intervalsRandom-effects modelWeb of ScienceCardiovascular deathCardiovascular eventsFailure hospitalization
2021
Procedural and In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Acute Myocardial Infarction: Insights From a Prospective Multicenter International Registry.
Arman P, Basir M, Gupta A, Choi J, Khatri J, Jaffer F, Poomipanit P, Forouzandeh F, Koutouzis M, Tsiafoutis I, Patel M, Mahmud E, Vemmou E, Nikolakopoulos I, Karacsonyi J, ElGuindy A, Goktekin O, Abi Rafeh N, Brilakis E, Alaswad K. Procedural and In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Acute Myocardial Infarction: Insights From a Prospective Multicenter International Registry. Journal Of Invasive Cardiology 2021, 33: e670-e676. PMID: 34473071.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPercutaneous coronary interventionNon-AMI patientsChronic total occlusion (CTO) percutaneous coronary interventionCTO-PCIAMI patientsCoronary interventionProcedural successTechnical successMyocardial infarctionHospital major adverse cardiovascular event (MACE) rateMajor adverse cardiovascular event ratesAdverse cardiovascular event ratesMulticenter international registrySimilar technical successIn-Hospital OutcomesCardiovascular event ratesProcedural success rateVentricular ejection fractionHemodynamic support devicesNon-CTO lesionsAntegrade wire escalationHospital MACEAngiographic characteristicsHospital outcomesComparison of Outcomes of Patients with vs without Previous Coronary Artery Bypass Graft Surgery Presenting with ST-Segment Elevation Acute Myocardial Infarction
Karacsonyi J, Schmidt CW, Okeson BK, Garcia S, Henry TD, Nikolakopoulos I, Vemmou E, Xenogiannis I, Sharkey S, Aguirre FV, Tannenbaum M, Burke M, Goessl M, Sorajja P, Traverse J, Wang YL, Brilakis ES. Comparison of Outcomes of Patients with vs without Previous Coronary Artery Bypass Graft Surgery Presenting with ST-Segment Elevation Acute Myocardial Infarction. The American Journal Of Cardiology 2021, 154: 33-40. PMID: 34243937, DOI: 10.1016/j.amjcard.2021.05.041.Peer-Reviewed Original ResearchConceptsPrevious coronary bypass graft surgeryST-segment elevation acute myocardial infarctionCoronary bypass graft surgeryElevation acute myocardial infarctionPrevious CABG patientsAcute myocardial infarctionCABG patientsBaseline characteristicsMyocardial infarctionMajor cardiac adverse eventsBypass graft surgeryCardiac adverse eventsOutcomes of patientsSaphenous vein graftsKaplan-Meier methodLong-term outcomesLog-rank testComparison of outcomesSTEMI registryGraft surgerySTEMI patientsAdverse eventsMost patientsPrimary outcomeTerm outcomesIn-Stent CTO Percutaneous Coronary Intervention Individual Patient Data Pooled Analysis of 4 Multicenter Registries
Vemmou E, Quadros AS, Dens JA, Rafeh NA, Agostoni P, Alaswad K, Avran A, Belli KC, Carlino M, Choi JW, El-Guindy A, Jaffer FA, Karmpaliotis D, Khatri JJ, Khelimskii D, Knaapen P, La Manna A, Krestyaninov O, Lamelas P, Ojeda S, Padilla L, Pan M, Piccaro de Oliveira P, Rinfret S, Spratt JC, Tanabe M, Walsh S, Nikolakopoulos I, Karacsonyi J, Rangan BV, Brilakis ES, Azzalini L. In-Stent CTO Percutaneous Coronary Intervention Individual Patient Data Pooled Analysis of 4 Multicenter Registries. JACC Cardiovascular Interventions 2021, 14: 1308-1319. PMID: 34052151, DOI: 10.1016/j.jcin.2021.04.003.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsDe novo chronic total occlusionsChronic total occlusionPercutaneous coronary interventionHospital major adverse cardiovascular eventsCTO percutaneous coronary interventionMyocardial infarctionLong-term major adverse cardiovascular eventsStent restenosis chronic total occlusionsCoronary artery bypass graft surgeryOutcomes of PCIMean J-CTO scoreArtery bypass graft surgeryAdverse cardiovascular eventsBypass graft surgeryDe novo groupJ-CTO scorePatient-level dataCause deathPercutaneous CoronaryAngiographic characteristicsCardiovascular eventsGraft surgeryMulticenter registryVessel revascularizationOUTCOMES OF PATIENTS WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND HISTORY OF PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY: UPDATE FROM THE MIDWEST STEMI CONSORTIUM
Karacsonyi J, Okeson B, Schmidt C, Garcia S, Henry T, Nikolakopoulos I, Vemmou E, Xenogiannis I, Rangan B, Goessl M, Sorajja P, Chavez I, Mooney M, Poulose A, Traverse J, Wang Y, Baran K, Bradley S, Garberich R, Ungi I, Burke M, Brilakis E. OUTCOMES OF PATIENTS WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND HISTORY OF PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY: UPDATE FROM THE MIDWEST STEMI CONSORTIUM. Journal Of The American College Of Cardiology 2021, 77: 1062. DOI: 10.1016/s0735-1097(21)02421-9.Peer-Reviewed Original ResearchST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN YOUNG AND VERY YOUNG PATIENTS:INCIDENCE AND OUTCOMES FROM THE MIDWEST STEMI CONSORTIUM
Nikolakopoulos I, Okeson B, Schmidt C, Garcia S, Henry T, Sharkey S, Gossl M, Chavez I, Mooney M, Traverse J, Wang Y, Poulose A, Sorajja P, Burke M, Karacsonyi J, Vemmou E, Brilakis E. ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN YOUNG AND VERY YOUNG PATIENTS:INCIDENCE AND OUTCOMES FROM THE MIDWEST STEMI CONSORTIUM. Journal Of The American College Of Cardiology 2021, 77: 2. DOI: 10.1016/s0735-1097(21)01345-0.Peer-Reviewed Original ResearchCan History of Myocardial Infarction Reliably Indicate Myocardial Viability in Patients With a Coronary Chronic Total Occlusion and Good Collateral Circulation?
Nikolakopoulos I, Vemmou E, Karacsonyi J, Xenogiannis I, Rangan BV, Garcia S, Burke MN, Brilakis ES. Can History of Myocardial Infarction Reliably Indicate Myocardial Viability in Patients With a Coronary Chronic Total Occlusion and Good Collateral Circulation? Journal Of Invasive Cardiology 2021, 33: e135. PMID: 33531443.Peer-Reviewed Original ResearchConceptsCoronary chronic total occlusionsGood collateral circulationChronic total occlusionMyocardial infarctionCollateral circulationTotal occlusionPrior Q-wave myocardial infarctionQ-wave myocardial infarctionPercutaneous coronary interventionPrior myocardial infarctionPROGRESS CTOMulticenter registryCoronary interventionEjection fractionPredominant symptomViable myocardiumMyocardial viabilityPatientsViability testingOcclusionDyspneaInfarctionRegistrySymptomsMyocardium
2020
Systematic review and meta-analysis of short-term outcomes with drug-coated balloons vs. stenting in acute myocardial infarction
Megaly M, Buda KG, Xenogiannis I, Vemmou E, Nikolakopoulos I, Saad M, Rinfret S, Abbott JD, Aronow HD, Garcia S, Pershad A, Burke MN, Brilakis ES. Systematic review and meta-analysis of short-term outcomes with drug-coated balloons vs. stenting in acute myocardial infarction. Cardiovascular Intervention And Therapeutics 2020, 36: 481-489. PMID: 33037991, DOI: 10.1007/s12928-020-00713-y.Peer-Reviewed Original ResearchConceptsDrug-coated balloonsAcute myocardial infarctionMyocardial infarctionAMI patientsOutcomes of DCBMajor adverse cardiovascular eventsAdverse cardiovascular eventsLate lumen lossShort-term outcomesLesion revascularizationCardiovascular eventsCause mortalityAngiographic outcomesCardiac deathLumen lossSimilar riskClinical utilityPatientsSystematic reviewLarger studyInfarctionStatistical differenceOutcomesMonthsBalloonCoronary Intravascular Brachytherapy for Recurrent Coronary Drug-Eluting Stent In-Stent Restenosis: A Systematic Review and Meta-Analysis
Megaly M, Glogoza M, Xenogiannis I, Vemmou E, Nikolakopoulos I, Omer M, Saad M, Willson L, Monyak DJ, Sullivan P, Pershad A, Chavez I, Mooney M, Traverse J, Wang Y, Garcia S, Poulose A, Burke MN, Brilakis ES. Coronary Intravascular Brachytherapy for Recurrent Coronary Drug-Eluting Stent In-Stent Restenosis: A Systematic Review and Meta-Analysis. Cardiovascular Revascularization Medicine 2020, 23: 28-35. PMID: 32883584, DOI: 10.1016/j.carrev.2020.08.035.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationIncidence of TVRIncidence of MIRecurrent ISRMyocardial infarctionCause mortalityStent restenosisSystematic reviewIntravascular brachytherapyOutcomes of interestVessel revascularizationCoronary DrugObservational studyMeta-AnalysisIncidencePrevious treatmentBrachytherapyTwo yearsPatientsRestenosisMortalityStentsOutcomesTreatmentLimited studiesImpact of Intravascular Ultrasound Utilization for Stent Optimization on 1-Year Outcomes After Chronic Total Occlusion Percutaneous Coronary Intervention.
Vemmou E, Khatri J, Doing AH, Dattilo P, Toma C, Sheikh A, Alaswad K, Jefferson BK, Patel TN, Chandwaney RH, Jaffer FA, Jaber W, Samady H, Gkargkoulas F, Moses JW, Lembo NJ, Kirtane AJ, Parikh M, Ali ZA, Megaly M, Omer M, Nikolakopoulos I, Xenogiannis I, Stanberry L, Garberich RF, Rangan BV, Garcia S, Burke MN, Abdullah S, Banerjee S, Brilakis ES, Karmpaliotis D. Impact of Intravascular Ultrasound Utilization for Stent Optimization on 1-Year Outcomes After Chronic Total Occlusion Percutaneous Coronary Intervention. Journal Of Invasive Cardiology 2020, 32: 392-399. PMID: 32694224.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionIVUS groupCTO-PCIStent optimizationCoronary interventionIncidence of MACEUltrasound utilizationHigher lesion complexityAdverse cardiac eventsTarget vessel revascularizationAcute coronary syndromePrior myocardial infarctionJ-CTO scoreLong-term outcomesUnited States CentersAntegrade wire escalationIVUS useCoronary syndromeCardiac eventsPatient ageCardiac deathMyocardial infarctionLesion complexityOutcomes With Combined Laser Atherectomy and Intravascular Brachytherapy in Recurrent Drug-Eluting Stent In-Stent Restenosis
Megaly M, Glogoza M, Xenogiannis I, Vemmou E, Nikolakopoulos I, Omer M, Willson L, Monyak DJ, Sullivan P, Stanberry L, Chavez I, Mooney M, Traverse J, Wang Y, Garcia S, Poulose A, Burke MN, Brilakis ES. Outcomes With Combined Laser Atherectomy and Intravascular Brachytherapy in Recurrent Drug-Eluting Stent In-Stent Restenosis. Cardiovascular Revascularization Medicine 2020, 22: 29-33. PMID: 32571761, DOI: 10.1016/j.carrev.2020.06.019.Peer-Reviewed Original ResearchConceptsTarget lesion failureTarget lesion revascularizationLong-term outcomesVascular brachytherapyDrug-eluting stentsMyocardial infarctionLaser atherectomyDES-ISRCardiac deathStent restenosisIncidence of TLFComparable long-term outcomesRecurrent DES-ISRExcimer laser atherectomyLesion myocardial infarctionTarget-lesion myocardial infarctionRecurrent drugsLesion failureLesion revascularizationISR lesionsStent underexpansionSingle institutionTarget lesionsAtherectomyStudy periodOutcomes of intravascular brachytherapy for recurrent drug‐eluting in‐stent restenosis
Megaly M, Glogoza M, Xenogiannis I, Vemmou E, Nikolakopoulos I, Willson L, Monyak DJ, Sullivan P, Stanberry L, Sorajja P, Chavez I, Mooney M, Traverse J, Wang Y, Garcia S, Poulose A, Burke MN, Brilakis ES. Outcomes of intravascular brachytherapy for recurrent drug‐eluting in‐stent restenosis. Catheterization And Cardiovascular Interventions 2020, 97: 32-38. PMID: 31943747, DOI: 10.1002/ccd.28716.Peer-Reviewed Original ResearchConceptsTarget lesion failureTarget lesion revascularizationRecurrent DES-ISRAcute coronary syndromeVascular brachytherapyDrug-eluting stentsDES-ISRMyocardial infarctionLower incidenceInitial presentationStent restenosisIncidence of TLRHigher TLFUse of IVUSProportional hazards analysisTertiary care institutionIntravascular ultrasound guidanceLong-term outcomesLesion myocardial infarctionTarget-lesion myocardial infarctionLesion revascularizationCoronary syndromeLesion failureCardiac deathUltrasound guidance
2019
Chronic total occlusion recanalization for myocardial infarction
Xenogiannis I, Nikolakopoulos I, Vemmou E, Brilakis ES. Chronic total occlusion recanalization for myocardial infarction. Catheterization And Cardiovascular Interventions 2019, 95: 1133-1135. PMID: 31696624, DOI: 10.1002/ccd.28590.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsRight coronary arteryCoronary arteryMyocardial infarctionNon-ST segment elevation acute myocardial infarctionRight coronary artery chronic total occlusionCoronary artery chronic total occlusionPrior coronary artery bypass surgerySegment elevation acute myocardial infarctionArtery chronic total occlusionProximal right coronary arteryCoronary artery bypass surgeryElevation acute myocardial infarctionChronic total occlusion recanalizationArtery bypass surgeryAcute vessel closureChronic total occlusionAmplatzer vascular plugAcute myocardial infarctionSVG anastomosisComplete revascularizationCulprit lesionBypass surgeryDistal anastomosisVascular plug