2024
Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment developmentBipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptomsBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Mirza S, Lima C, Del Favero-Campbell A, Rubinstein A, Topolski N, Cabrera-Mendoza B, Kovács E, Blumberg H, Richards J, Williams A, Wemmie J, Magnotta V, Fiedorowicz J, Gaine M, Walss-Bass C, Quevedo J, Soares J, Fries G. Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder. Translational Psychiatry 2024, 14: 70. PMID: 38296944, PMCID: PMC10831084, DOI: 10.1038/s41398-024-02760-y.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDifferentially methylated regionsDifferentially methylated positionsAssociation studiesCo-methylation network analysisBipolar disorderDNA methylation patternsSuicide attemptsReplication cohortHistory of SAGene ontology analysisSignificant CpG sitesMethylation patternsDNA methylationCpG sitesOntology analysisImmune-related genesEnrichment analysisNon-psychiatric controlsCalcium signalingGenesDNAClinical interviewSA historyNetwork analysisPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2023
Estradiol effects on an emotional interference task in adolescents with current and remitted depression
Sullivan A, Chung Y, Novotny S, Epperson C, Kober H, Blumberg H, Gross J, Ochsner K, Pearlson G, Stevens M. Estradiol effects on an emotional interference task in adolescents with current and remitted depression. Hormones And Behavior 2023, 157: 105450. PMID: 37923628, PMCID: PMC10842169, DOI: 10.1016/j.yhbeh.2023.105450.Peer-Reviewed Original ResearchAttentional biasesFacial expressionsAdolescent femalesRemitted depressionEmotional facial expressionsNeutral facial expressionsEmotional interference taskAttention capture effectsMajor depressive disorderMDD groupResponse reaction timesGroups of participantsMain effectHappy stimuliInterference taskEmotional stimuliEmotional contentAI scoreControl adolescentsDisorder onsetInterference scoresGroup interactionMDD adolescentsSex hormone estradiolAdolescentsSex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project
Blanken M, Oudega M, Almeida O, Schouws S, Orhan M, Beunders A, Klumpers U, Sonnenberg C, Blumberg H, Eyler L, Forester B, Forlenza O, Gildengers A, Mulsant B, Rajji T, Rej S, Sarna K, Sutherland A, Yala J, Vieta E, Tsai S, Briggs F, Sajatovic M, Dols A. Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project. American Journal Of Geriatric Psychiatry 2023, 32: 326-338. PMID: 37981507, DOI: 10.1016/j.jagp.2023.10.008.Peer-Reviewed Original ResearchOlder age bipolar disorderBipolar disorderPsychiatric hospitalizationMood symptomsSex differencesClinical sex differencesMore psychiatric hospitalizationsPhysical health comorbiditiesLifetime psychiatric comorbidityGlobal AGEingBipolar Disorder (STEP-BD) studySex-specific researchAdult bipolar disorderSubstance abuse disordersDepressive mood symptomsOld age womenClinical characteristicsHealth comorbiditiesSevere courseClinical presentationStudy cohortMale sexPsychiatric comorbidityFemale sexAge womenPredictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative
Burdick K, Millett C, Yocum A, Altimus C, Andreassen O, Aubin V, Belzeaux R, Berk M, Biernacka J, Blumberg H, Cleare A, Diaz-Byrd C, Dubertret C, Etain B, Eyler L, Forester B, Fullerton J, Frye M, Gard S, Godin O, Haffen E, Klaus F, Lagerberg T, Leboyer M, Martinez-Aran A, McElroy S, Mitchell P, Olie E, Olorunfemi P, Passerieux C, Peters A, Pham D, Polosan M, Potter J, Sajatovic M, Samalin L, Schwan R, Shanahan M, Solé B, Strawbridge R, Stuart A, Torres I, Ueland T, Vieta E, Williams L, Wrobel A, Yatham L, Young A, Nierenberg A, McInnis M. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative. FOCUS The Journal Of Lifelong Learning In Psychiatry 2023, 21: 444-452. PMID: 38694997, PMCID: PMC11058953, DOI: 10.1176/appi.focus.23021021.Peer-Reviewed Original ResearchBipolar disorderFunctional impairmentComplete recoveryComorbid substance use disorderPersistent functional impairmentPatient's complete recoveryLogistic regression analysisPrior mood episodesProspective longitudinal studySubstance use disordersPsychotropic medicationsHeterogeneous presentationMood episodesClinical research communityDepressive symptomsOptimizing outcomesUse disordersCohortLower functioningLongitudinal studyRegression analysisGreater total numberHigh rateMultiple cohortsImpairmentDemographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project
Mallu A, Chan C, Eyler L, Dols A, Rej S, Blumberg H, Sarna K, Forester B, Patrick R, Forlenza O, Jimenez E, Vieta E, Schouws S, Sutherland A, Yala J, Briggs F, Sajatovic M. Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project. Bipolar Disorders 2023, 25: 637-647. PMID: 37798096, PMCID: PMC10843228, DOI: 10.1111/bdi.13381.Peer-Reviewed Original ResearchEssential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group
Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group. Bipolar Disorders 2023, 25: 554-563. PMID: 36843436, DOI: 10.1111/bdi.13312.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGeneral medical comorbidityGeriatric mental healthSubgroup of patientsInternational data collectionSubjective cognitive functionMedical comorbiditiesCurrent medicationsPsychiatric comorbidityFamily historyDelphi consensusPsychotic symptomsBD diagnosisClinical practiceSystematic reviewCognitive functionCore symptomsMental healthGlobal AGEingComorbiditiesDisordersSymptomsInitial recommendationsData collectionPredicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes
Sankar A, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes. Psychological Medicine 2023, 53: 6656-6665. PMID: 36891769, PMCID: PMC10491744, DOI: 10.1017/s003329172300003x.Peer-Reviewed Original ResearchBipolar disorderYoung Mania Rating ScaleMania Rating ScaleFunctional connectomeBrain functional connectomeSymptom scoresHamilton DepressionMagnetic resonance imaging dataEmotion processing taskMood symptomatologyRating ScaleFunctional magnetic resonance imaging (fMRI) dataConnectomeAdultsImaging dataIndependent samplesPredictive abilitySymptomatologyConcurrent Validity and Reliability of Suicide Risk Assessment Instruments: A Meta-Analysis of 20 Instruments Across 27 International Cohorts
Campos A, Van Velzen L, Veltman D, Pozzi E, Ambrogi S, Ballard E, Banaj N, Başgöze Z, Bellow S, Benedetti F, Bollettini I, Brosch K, Canales-Rodríguez E, Clarke-Rubright E, Colic L, Connolly C, Courtet P, Cullen K, Dannlowski U, Dauvermann M, Davey C, Deverdun J, Dohm K, Erwin-Grabner T, Goya-Maldonado R, Fani N, Fortea L, Fuentes-Claramonte P, Gonul A, Gotlib I, Grotegerd D, Harris M, Harrison B, Haswell C, Hawkins E, Hill D, Hirano Y, Ho T, Jollant F, Jovanovic T, Kircher T, Klimes-Dougan B, le Bars E, Lochner C, McIntosh A, Meinert S, Mekawi Y, Melloni E, Mitchell P, Morey R, Nakagawa A, Nenadić I, Olié E, Pereira F, Phillips R, Piras F, Poletti S, Pomarol-Clotet E, Radua J, Ressler K, Roberts G, Rodriguez-Cano E, Sacchet M, Salvador R, Sandu A, Shimizu E, Singh A, Spalletta G, Steele J, Stein D, Stein F, Stevens J, Teresi G, Uyar-Demir A, van der Wee N, van der Werff S, van Rooij S, Vecchio D, Verdolini N, Vieta E, Waiter G, Whalley H, Whittle S, Yang T, Zarate C, Thompson P, Jahanshad N, van Harmelen A, Blumberg H, Schmaal L, Rentería M. Concurrent Validity and Reliability of Suicide Risk Assessment Instruments: A Meta-Analysis of 20 Instruments Across 27 International Cohorts. Neuropsychology 2023, 37: 315-329. PMID: 37011159, PMCID: PMC10132776, DOI: 10.1037/neu0000850.Peer-Reviewed Original Research
2022
Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder
Dauvermann M, Schmaal L, Colic L, van Velzen L, Bellow S, Ford T, Suckling J, Goodyer I, Consortium I, Blumberg H, van Harmelen A. Elevated cognitive rumination and adverse life events are associated with lower cortical surface area and suicidal ideation in adolescents with major depressive disorder. Journal Of Affective Disorders 2022, 325: 93-101. PMID: 36584707, DOI: 10.1016/j.jad.2022.12.087.Peer-Reviewed Original ResearchAging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
Villa L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume. Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.Peer-Reviewed Original ResearchConceptsGray matter volumeOccipital cortical thicknessSubcortical gray matter volumesCortical thicknessBipolar disorderMatter volumeOlder adultsOnset of BDIndividuals age 40Striatal gray matter volumeGray matter reductionsOnset bipolar disorderGray matter decreasesPrefrontal cortical thicknessStructural brain differencesHigh suicide riskCross-sectional designHealthy controlsCognitive dysfunctionTreatment resistanceAge 40Striatal volumeSevere symptomsSuicide attempt historySuicide attemptsBipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Beunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project. Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.Peer-Reviewed Original ResearchConceptsBD II patientsStudy cohortBD subtypesSomatic burdenMultivariable analysisGeneral functioningBD-IIGlobal AGEingBD-I patientsCross-sectional analysisClinical factorsClinical differencesSevere depressionPsychiatric hospitalizationBipolar ICognitive impairmentLate onsetPatientsOlder ageDiagnostic definitionSubtypesGeneralized linear mixed modelCohortLinear mixed modelsRandom interceptBrain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders
Colic L, Villa L, Dauvermann M, van Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Quatrano S, Spencer L, Constable R, Suckling J, Goodyer I, Schmaal L, van Harmelen A, Blumberg H. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders. JCPP Advances 2022, 2 PMID: 36817186, PMCID: PMC9937714, DOI: 10.1002/jcv2.12118.Peer-Reviewed Original ResearchDifferences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder
Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMetabotropic glutamate receptor 5Glutamate receptor 5MGluR5 availabilityBipolar disorderPositron emission tomographyHC groupDepressive disorderReceptor 5Emission tomographyHealthy control individualsPossible treatment targetsGlutamate transmissionBD depressionTreatment strategiesBD groupMGluR5Depressive symptomsNovel treatmentsCognitive alterationsTreatment targetsSynaptic plasticityControl individualsAccurate diagnosisSignificant negative correlationClinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults
Lavin P, Buck G, Almeida O, Su C, Eyler L, Dols A, Blumberg H, Forester B, Forlenza O, Gildengers A, Mulsant B, Tsai S, Vieta E, Schouws S, Briggs F, Sutherland A, Sarna K, Yala J, Orhan M, Korten N, Sajatovic M, Rej S, Investigators G. Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults. International Journal Of Geriatric Psychiatry 2022, 37 PMID: 36317317, DOI: 10.1002/gps.5833.Peer-Reviewed Original ResearchA graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentStructural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.Peer-Reviewed Original ResearchConceptsMood disordersSuicidal thoughtsSuicide attemptsBrain alterationsMRI metricsSuicidal ideationColumbia-Suicide Severity Rating ScaleStructural brain alterationsLifetime suicide attemptsSeverity Rating ScaleCurrent suicidal ideationActual suicide attemptsHealthy controlsAssessment instrumentsClinical controlEarly interventionMental disordersSignificant associationFrontal poleBrain morphologySuicide riskSuicide attemptersRating ScaleYoung peopleDisorders