2010
Functional Analyses of the Bone Marrow Kinase in the X Chromosome in Vascular Endothelial Growth Factor–Induced Lymphangiogenesis
Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W. Functional Analyses of the Bone Marrow Kinase in the X Chromosome in Vascular Endothelial Growth Factor–Induced Lymphangiogenesis. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 2553-2561. PMID: 20864667, PMCID: PMC3106279, DOI: 10.1161/atvbaha.110.214999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCorneaEndothelial CellsFemaleHumansLymphangiogenesisLymphatic VesselsMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationProtein-Tyrosine KinasesRecombinant ProteinsRNA InterferenceSignal TransductionSkinTransfectionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-3ConceptsBone marrow kinaseX chromosomeLymphatic endothelial cell tube formationVascular endothelial growth factorVEGFR-3 receptorRole of BmxLymphatic endothelial cellsEndothelial cell tube formationVEGFR-2 activationCell tube formationLymphangiogenic signalingReceptor autophosphorylationFunctional analysisLymphangiogenic responseFirst insightPathological angiogenesisWild-type micePharmacological inhibitionTube formationBMXChromosomesKinaseVEGFR-3Critical roleSignaling
2006
Differential Functions of Tumor Necrosis Factor Receptor 1 and 2 Signaling in Ischemia-Mediated Arteriogenesis and Angiogenesis
Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W. Differential Functions of Tumor Necrosis Factor Receptor 1 and 2 Signaling in Ischemia-Mediated Arteriogenesis and Angiogenesis. American Journal Of Pathology 2006, 169: 1886-1898. PMID: 17071609, PMCID: PMC1780200, DOI: 10.2353/ajpath.2006.060603.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsArteriesBlood VesselsCattleCell MovementCell ProliferationCell SurvivalEndothelial CellsEndothelium, VascularHindlimbHumansIschemiaMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataNeovascularization, PathologicOrganogenesisPerfusionProtein-Tyrosine KinasesReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISignal TransductionTNF Receptor-Associated Factor 2ConceptsTNFR2 KO miceTumor necrosis factorTNFR1-KOEndothelial cellsFemoral artery ligation modelIschemia-mediated arteriogenesisIschemic reserve capacityTNFR1 knockout miceInfiltration of macrophagesTumor necrosis factor receptor 1Wild-type miceArtery ligation modelNecrosis factor receptor 1Dependent reporter gene expressionNuclear factor-kappaBEC survivalFactor receptor 1Vascular endothelial cellsActivation of TNFR1Murine endothelial cellsTNFR2-KOClinical recoveryActivation of TNFR2Limb perfusionVascular proliferation