2022
The Art, Science, and Secrets of Scanning Young Children
Spann M, Wisnowski J, Group H, Ahtam B, Gao W, Huang H, Nebel M, Norton E, Ouyang M, Rajagopalan V, Riggins T, Saygin Z, Scott L, Smyser C, Thomason M, Wakschlag L, Smyser C, Fetal I, Ahmad S, Aydin E, Barkovich A, Berger-Jenkins E, Brick J, Bowman L, Camacho M, Lugo-Candelas C, Cusack R, DuBois J, Dufford A, Elison J, Ellis C, Ferradal S, Filippi C, Ford A, Fouladivanda M, Gaab N, Gano D, Ganz-Benjaminsen M, Ghetti S, Glenn O, Gomez M, Graham A, Hendrix C, Holland C, Humphreys K, Korom M, Kosakowski H, Li G, Manessis A, Nolvi S, Pineda R, Pollatou A, Rae C, Rasmussen J, Scheinost D, Shultz S, Simon-Martinez C, Madsen K, Sung S, Sylvester C, Turesky T, Vaughn K, Wagner L, Wang L, Warton F, Wilson S, Wintermark P, Wu Y, Yap P, Yates T, Yen E, Yu X, Zhu H, Zöllei L, Howell B, Dean D. The Art, Science, and Secrets of Scanning Young Children. Biological Psychiatry 2022, 93: 858-860. PMID: 36336497, PMCID: PMC10050222, DOI: 10.1016/j.biopsych.2022.09.025.Peer-Reviewed Original ResearchAssociations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratio
2021
Resample aggregating improves the generalizability of connectome predictive modeling
O’Connor D, Lake EMR, Scheinost D, Constable RT. Resample aggregating improves the generalizability of connectome predictive modeling. NeuroImage 2021, 236: 118044. PMID: 33848621, PMCID: PMC8282199, DOI: 10.1016/j.neuroimage.2021.118044.Peer-Reviewed Original ResearchFunctional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol
Horien C, Fontenelle S, Joseph K, Powell N, Nutor C, Fortes D, Butler M, Powell K, Macris D, Lee K, Greene AS, McPartland JC, Volkmar FR, Scheinost D, Chawarska K, Constable RT. Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol. Scientific Reports 2020, 10: 21855. PMID: 33318557, PMCID: PMC7736342, DOI: 10.1038/s41598-020-78885-z.Peer-Reviewed Original ResearchConceptsPediatric participantsMRI protocolMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansShorter MRI protocolsScan protocolResonance imaging scansImaging scansMRI sessionsFMRI connectivity analysisFMRI dataFMRI findingsSignificant confoundScansReplication groupConnectivity analysisAutism spectrum disorderMock scanSpectrum disorderParticipantsHead motionProtocolBehavioral and brain signatures of substance use vulnerability in childhood
Rapuano KM, Rosenberg MD, Maza MT, Dennis NJ, Dorji M, Greene AS, Horien C, Scheinost D, Constable R, Casey BJ. Behavioral and brain signatures of substance use vulnerability in childhood. Developmental Cognitive Neuroscience 2020, 46: 100878. PMID: 33181393, PMCID: PMC7662869, DOI: 10.1016/j.dcn.2020.100878.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingSubstance useFunctional connectivityCognitive Development StudyFuture substance useSubstance use vulnerabilityAdolescent substance useSubstance use increasesSubstance use outcomesIndividual differencesAdolescent brainBrain signaturesTask conditionsBehavioral measuresFamilial risk factorsUse outcomesRisky behaviorsLatent dimensionsFamilial factorsBrain modelCurrent studyWeak predictorDevelopment studiesEarly susceptibilityFunctional imaging
2016
Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization
Kwon SH, Scheinost D, Vohr B, Lacadie C, Schneider K, Dai F, Sze G, Constable RT, Ment LR. Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization. Developmental Medicine & Child Neurology 2016, 58: 28-34. PMID: 27027605, PMCID: PMC6426123, DOI: 10.1111/dmcn.13043.Peer-Reviewed Original ResearchLanguage at rest: A longitudinal study of intrinsic functional connectivity in preterm children
Rowlands MA, Scheinost D, Lacadie C, Vohr B, Li F, Schneider KC, Constable R, Ment LR. Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children. NeuroImage Clinical 2016, 11: 149-157. PMID: 26937383, PMCID: PMC4753807, DOI: 10.1016/j.nicl.2016.01.016.Peer-Reviewed Original ResearchConceptsLeft occipito-temporal cortexOccipito-temporal cortexVerbal IQPerformance IQLanguage deficitsSignificant connectivity reductionsPreterm childrenIntrinsic functional connectivityFull IQFunctional connectivity networksFunctional connectivityIQAge 8PT childrenConnectivity reductionLong-range connectionsWorse performanceLinear mixed effects modelsLongitudinal studyConnectivity networksAge 16PT subjectsTS childrenCortical connectivityTerm children
2015
Normalization of brain morphology after surgery in sagittal craniosynostosis.
Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA. Normalization of brain morphology after surgery in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2015, 17: 460-8. PMID: 26684766, PMCID: PMC7182140, DOI: 10.3171/2015.7.peds15221.Peer-Reviewed Original ResearchConceptsBrain growthNonsyndromic craniosynostosisBrain morphological differencesWhole-brain techniqueYears of ageSignificant learning disabilitiesIQ-matched control subjectsUntreated infantsMean ageAdolescent patientsControl subjectsWhole-vault cranioplastyBrain dysmorphologySurgical reconstructionBrain areasTemporooccipital regionsSmall cohortSurgeryCognitive functionBrain morphologyBrain normalizationSagittal craniosynostosisLiberal thresholdSagittal nonsyndromic craniosynostosisFrontoparietal regionsA neuromarker of sustained attention from whole-brain functional connectivity
Rosenberg MD, Finn ES, Scheinost D, Papademetris X, Shen X, Constable RT, Chun MM. A neuromarker of sustained attention from whole-brain functional connectivity. Nature Neuroscience 2015, 19: 165-171. PMID: 26595653, PMCID: PMC4696892, DOI: 10.1038/nn.4179.Peer-Reviewed Original Research
2014
Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity
Lee HW, Arora J, Papademetris X, Tokoglu F, Negishi M, Scheinost D, Farooque P, Blumenfeld H, Spencer DD, Constable RT. Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity. Neurology 2014, 83: 2269-2277. PMID: 25391304, PMCID: PMC4277677, DOI: 10.1212/wnl.0000000000001068.Peer-Reviewed Original ResearchConceptsSeizure onset zoneIntrinsic connectivity contrastTemporal lobe epilepsyLobe epilepsySurgical outcomesOnset zoneExtratemporal lobe epilepsyIntractable partial epilepsyGood surgical outcomeAltered functional connectivityFunctional connectivity changesResting-state fMRIGlobal network changesEpileptic hemisphereClinical factorsPartial epilepsyEpileptogenic networksEpileptogenic zoneSeizure localizationFocal epilepsyIntracranial EEG recordingsTLE groupIndependent reviewersConnectivity abnormalitiesPatients
2013
Disruption of Functional Networks in Dyslexia: A Whole-Brain, Data-Driven Analysis of Connectivity
Finn ES, Shen X, Holahan JM, Scheinost D, Lacadie C, Papademetris X, Shaywitz SE, Shaywitz BA, Constable RT. Disruption of Functional Networks in Dyslexia: A Whole-Brain, Data-Driven Analysis of Connectivity. Biological Psychiatry 2013, 76: 397-404. PMID: 24124929, PMCID: PMC3984371, DOI: 10.1016/j.biopsych.2013.08.031.Peer-Reviewed Original ResearchConceptsFunctional connectivity analysisVisual word form areaConnectivity analysisWord form areaNon-impaired readersFunctional magnetic resonance imaging (fMRI) dataInferior frontal gyrusWhole-brain functional connectivity analysisAnterior language regionsVisual association areasWhole-brain connectivityAdult readersNeural basisImportance of synchronyFrontal gyrusSuccessful readingVisual stimuliLanguage regionsAttention areasBrain networksDiverse brain regionsMagnetic resonance imaging dataVisual informationDyslexiaVisual properties
2012
A left cerebellar pathway mediates language in prematurely-born young adults
Constable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.Peer-Reviewed Original ResearchConceptsPT subjectsTerm controlsInferior frontal gyrusFunctional MRIFunctional connectivityResting-state functional MRIYoung adultsCognitive outcomesSeed-based connectivity analysisAge 20 yearsSeed-based analysisAlternative neural pathwaysControl young adultsPreterm subjectsCerebellar connectivityNeural pathwaysCerebellar pathwaysIndex scoreNineteen ptsGray matterMaternal educationQuadrangular lobuleDevelopmental delayPT brainSignificant positive correlation