2011
S128 Highly invasive capsular serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to complement and phagocytosis
Hyams C, Trzcinski K, Weinberger D, Lipsitch M, Brown J. S128 Highly invasive capsular serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to complement and phagocytosis. Thorax 2011, 66: a59. DOI: 10.1136/thoraxjnl-2011-201054b.128.Peer-Reviewed Original ResearchC3b/iC3b depositionNeutrophil associationFH bindingIC3b depositionCapsular serotypesS pneumoniaeSerotype-dependent differencesC3b depositionCertain serotypesFresh human neutrophilsFlow cytometry assayAlternative complement pathwayNasopharyngeal colonisationComplement depositionNeutrophil phagocytosisInvasive serotypesCapsular thicknessComplement activityAlternative pathway activityCytometry assaysInvasive strainsEssential virulence factorFlow cytometryComplement pathwayHIGH FH
2009
Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
Weinberger DM, Trzciński K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence. PLOS Pathogens 2009, 5: e1000476. PMID: 19521509, PMCID: PMC2689349, DOI: 10.1371/journal.ppat.1000476.Peer-Reviewed Original ResearchConceptsSerotype replacementCarriage prevalenceNasopharyngeal carriageCapsular serotypesNon-vaccine serotypesNeutrophil-mediated killingNasopharyngeal carriage prevalenceCapsular polysaccharideVaccinated populationSerotype prevalenceEpidemiological patternsPrevalent serotypesStreptococcus pneumoniaeBacterial factorsParticular serotypePrevalenceImportant serotypesNovel biological principleSerotypesDifferent serotypesCarriageNeutrophilsBiological differencesKillingVaccination