2016
Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor
Kong L, Zhao Y, Tian Q, Feng J, Kobayashi T, Merregaert J, Liu C. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor. The FASEB Journal 2016, 30: 2741-2754. PMID: 27075243, PMCID: PMC4970607, DOI: 10.1096/fj.201600261r.Peer-Reviewed Original ResearchConceptsExtracellular matrix protein 1Matrix protein 1Protein 1Endochondral ossificationCellular signaling pathwaysGrowth factorRegulation of chondrogenesisEndochondral bone formationUnrecognized regulatorChondrogenic growth factorsInteraction networksPTHrP regulationCartilage developmentSignaling pathwaysParathyroid hormone-related peptideTarget transgeneMatrix proteinsChondrocyte differentiationCellular interactionsHormone-related peptideChondrogenesisChondrocyte hypertrophyPTHrP actionOverexpressionPathway
2011
Progranulin: A growth factor, a novel TNFR ligand and a drug target
Liu C, Bosch X. Progranulin: A growth factor, a novel TNFR ligand and a drug target. Pharmacology & Therapeutics 2011, 133: 124-132. PMID: 22008260, PMCID: PMC4429904, DOI: 10.1016/j.pharmthera.2011.10.003.Peer-Reviewed Original ResearchConceptsGrowth factorAdministration of progranulinCollagen-induced arthritisAnti-inflammatory effectsArthritis mouse modelAnti-inflammatory propertiesExact molecular pathwaysInflammatory arthritisRheumatoid arthritisNeurotrophic factorArthritic processImmune cellsNecrosis factorMouse modelTNFR ligandsProgranulinFrontotemporal dementiaPGRN proteinArthritisPGRN geneExperimental modelCancer cellsCrucial mediatorEpithelial cellsChondrogenic growth factors
2009
ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor
Bai X, Wang D, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg H, Yu X, Liu C. ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor. Molecular And Cellular Biology 2009, 29: 4201-4219. PMID: 19487464, PMCID: PMC2715794, DOI: 10.1128/mcb.00056-09.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS7 ProteinAnimalsBlotting, WesternBone and BonesBone DevelopmentCell DifferentiationCell LineCell Line, TumorChondrocytesGene Expression ProfilingHumansImmunohistochemistryImmunoprecipitationIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutParathyroid Hormone-Related ProteinProgranulinsProtein BindingProtein PrecursorsReverse Transcriptase Polymerase Chain ReactionTissue Culture TechniquesTwo-Hybrid System TechniquesConceptsADAMTS-7Granulin-epithelin precursorEndochondral bone formationEndochondral bone growthGrowth factorBone formationChondrocyte differentiationBone growthDirect targetAutocrine growth factorGrowth plate chondrocytesProteolytic activityPTHrPChondrogenic growth factorsChondrocyte hypertrophyExtracellular matrix proteinsCartilage extracellular matrix proteinsImportant targetADAMTS familyInhibitionSkeletal developmentMatrix proteinsExpression patternsExtracellular matrixArthritis