2015
Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders
Bolling DZ, Pelphrey KA, Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderPosterior superior temporal sulcusUnaffected siblingsAtypical neural processingSocial exclusionFunctional magnetic resonance imagingSuperior temporal sulcusAbnormal neural responsesAnterior temporoparietal junctionAnterior cingulate cortexEmotion processingTemporoparietal junctionNegative affectTemporal sulcusNeural processingBrain responsesNeural endophenotypesNeural responsesNeural activationCingulate cortexNeural circuitrySocial experienceASD probandsPowerful feelings
2013
Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
Gordon I, Eilbott JA, Feldman R, Pelphrey KA, Vander Wyk B. Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses. Social Neuroscience 2013, 8: 544-554. PMID: 24044427, DOI: 10.1080/17470919.2013.832374.Peer-Reviewed Original ResearchConceptsJoint attentionTemporoparietal junctionIncongruent responsesFMRI paradigmFunctional magnetic resonance imaging (fMRI) researchDorsal anterior cingulate cortexNaturalistic fMRI paradigmsHuman social functioningImpact of congruencySocial responsesRight temporoparietal junctionEye gaze patternsRight fusiform gyrusPosterior parietal cortexMagnetic resonance imaging researchAnterior cingulate cortexSocial neuroscienceIncongruent trialsAttention circuitsFusiform gyrusCongruent responsesNeural activationBrain networksRight amygdalaSocial functioning
2011
Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism
Pitskel NB, Bolling DZ, Hudac CM, Lantz SD, Minshew NJ, Vander Wyk BC, Pelphrey KA. Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism. Journal Of Autism And Developmental Disorders 2011, 41: 1686-1693. PMID: 21484518, PMCID: PMC3337548, DOI: 10.1007/s10803-011-1197-x.Peer-Reviewed Original ResearchConceptsAverted gazeBrain mechanismsCritical social cueRight temporoparietal junctionLateral occipital cortexDorsolateral prefrontal cortexRight anterior insulaSocial processingTemporoparietal junctionSocial cuesComparison participantsAnterior insulaFMRI studySocial deficitsSocial scenariosGaze directionPrefrontal cortexCondition interactionAutismSocial encountersDifferential processingInitial evidenceOccipital cortexGazeSignificant group