1996
Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.
Sklair-Tavron L, Shi W, Lane S, Harris H, Bunney B, Nestler E. Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11202-11207. PMID: 8855333, PMCID: PMC38308, DOI: 10.1073/pnas.93.20.11202.Peer-Reviewed Original ResearchConceptsVTA dopamine neuronsVentral tegmental areaChronic morphine treatmentDopamine neuronsMorphine treatmentBrain regionsBrain-derived neurotrophic factorIntra-VTA infusionMorphine-treated ratsOpioid receptor antagonistChronic opiate exposureMesolimbic dopamine neuronsFluorescent dye Lucifer yellowMesolimbic dopamine functionMesolimbic dopamine systemImportant neural substrateDye Lucifer yellowNondopaminergic neuronsVTA neuronsChronic morphineOpiate exposureConcomitant treatmentDopaminergic neuronsNeurotrophic factorReceptor antagonist
1995
Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.
Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.Peer-Reviewed Original ResearchConceptsEffects of ritanserinBasal firing rateDA autoreceptorsDA neuronsDA agonistsP-chlorophenylalanineSubstantia nigra DA neuronsSingle-unit recording techniquesChloral hydrate-anesthetized ratsFiring rateDA agonist quinpiroleDirect DA agonistsIndirect DA agonistPostsynaptic D2 receptorsExtrapyramidal side effectsD2-like receptorsSignificant therapeutic effectAgonist-induced inhibitionMidbrain dopamine neuronsMidbrain dopamine systemAgonist quinpiroleDA antagonistsMDL 100907Receptor antagonistDopamine neurons
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatum
1986
Does the cholecystokinin antagonist proglumide possess antipsychotic activity?
Innis R, Bunney B, Charney D, Price L, Glazer W, Sternberg D, Rubin A, Heninger G. Does the cholecystokinin antagonist proglumide possess antipsychotic activity? Psychiatry Research 1986, 18: 1-7. PMID: 3737785, DOI: 10.1016/0165-1781(86)90056-9.Peer-Reviewed Original ResearchConceptsPsychosis ratingsPlacebo-controlled studyRole of cholecystokininCentral dopaminergic activityCCK receptor antagonistsPathogenesis of schizophreniaMesocortical neuronsNeuroleptic medicationNeurotransmitter statusReceptor antagonistDopaminergic activityAntipsychotic activitySchizophrenic patientsCholecystokininNegative findingsPreclinical researchProglumidePatientsSchizophreniaPotential reasonsMedicationsPathogenesisAntagonistMidbrainNeuropeptides
1985
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
Chiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.Peer-Reviewed Original ResearchConceptsDA neuronsClozapine administrationChronic treatmentDepolarization inactivationExtracellular single cell recording techniquesInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidVentral tegmental area (VTA) dopamineSingle cell recording techniquesA10 DA neuronsVivo spontaneous activityMidbrain DA neuronsChloral hydrate anesthesiaCombination of drugsMidbrain dopamine neuronsGamma-aminobutyric acidDifferential effectsMechanism of actionAcute treatmentMicroiontophoretic applicationSubstantia nigraReceptor antagonistDA cellsDopamine neuronsSpontaneous activity