Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities
Anticevic A, Repovs G, Barch DM. Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities. Schizophrenia Bulletin 2011, 39: 168-178. PMID: 21914644, PMCID: PMC3523909, DOI: 10.1093/schbul/sbr107.Peer-Reviewed Original ResearchConceptsSCZ subjectsWM pathologySample WM taskWhole-brain levelDorsolateral prefrontal cortex functioningDefault mode systemFunctional magnetic resonanceHealthy subjectsWM phasesAbnormalitiesSchizophreniaWM areasActivation differencesLess recruitmentPrefrontal regionsMaintenance phaseDeficitsPrefrontal cortex functioningSubstantial evidencePathologySubjectsMaintenance deficitsRecent findingsActivationMagnetic resonanceNegative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic A, Repovs G, Corlett PR, Barch DM. Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia. Biological Psychiatry 2011, 70: 1159-1168. PMID: 21861986, DOI: 10.1016/j.biopsych.2011.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaAnalysis of VarianceArousalAttentionCase-Control StudiesCerebral CortexDiscrimination, PsychologicalEmotionsFemaleField Dependence-IndependenceHumansLinear ModelsMagnetic Resonance ImagingMaleMatched-Pair AnalysisMemory, Short-TermMiddle AgedReference ValuesSchizophreniaSchizophrenic PsychologyVisual PerceptionConceptsControl subjectsSCZ subjectsDSM-IV-diagnosed schizophreniaAberrant salience processingLevel-dependent imagingAbility of patientsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cortical regionsFunctional magnetic resonanceLevel-dependent activityPathophysiological mechanismsPatientsResonance imagingCortical regionsAberrant responsesSalience processingSchizophreniaPrefrontal regionsEffects of distractionSubjectsSpecific deficitsDeficitsMagnetic resonanceSimilar responsesEmotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia
Anticevic A, Repovs G, Barch DM. Emotion Effects on Attention, Amygdala Activation, and Functional Connectivity in Schizophrenia. Schizophrenia Bulletin 2011, 38: 967-980. PMID: 21415225, PMCID: PMC3446234, DOI: 10.1093/schbul/sbq168.Peer-Reviewed Original ResearchConceptsAmygdala activationAmygdala recruitmentEmotional processingSimple perceptual decision tasksHigh-level cognitive processesFunctional connectivityRapid event-related fMRIPerceptual decision taskTask-based functional connectivityProcessing of affectEvent-related fMRIMinimal cognitive loadSCZ subjectsLevel of behaviorSignificant group differencesEmotion effectsNeutral distractionAffective cuesMoment perceptionsAffective stimuliNegative stimuliCognitive processesDecision taskNegative distractionCognitive load