In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
A precise architecture, maintained as neurons grow
Nerve cells make their connections at junctions called synapses, following a precise architecture that is mostly laid out early in development. But how do the synapses maintain their correct positions as the animal grows? Yale scientists have produced the first evidence that this process relies on glial cells and identified a novel molecular pathway that could be linked in humans to neurological disease.
Yale researchers trick bacteria to deliver a safer vaccine
Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues but Yale researchers have developed a new trick to circumvent the problem — using bacteria’s own cellular mistakes to deliver a safe vaccine.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Yale biologist peers into inner working of the cell
Daniel Colón-Ramos, assistant professor of cell biology, studies the C. elegans nematode, and uses the latest microscopy technology to watch neurons locate a target and form precise synaptic connections, resulting in the neural circuits that underlie human behavior. In this talk at a TEDx event in San Juan in November 2011, Colón-Ramos discusses "The Value of Basic Research in Medicine."Source: Yale News
Study: People Who Regularly Drink Alcohol Could Be More Prone to Internet, Gaming, and Exercise Addiction
An international research team with members that include Yale scientist Marc Potenza, MD, PhD, have identified several genes and their variants that trigger both substance use and other potentially addictive behaviors.
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
A Yale-led study published in JAMA Network Open is the first large-scale analysis to investigate phenotypic and genetic factors contributing to the psychiatric comorbidity of endometriosis, a complex gynecologic disease.
Cannabis Use is Associated With Low Plasma Endocannabinoid Anandamide in Individuals With Psychosis
Anahita Bassir Nia, MD, assistant professor of psychiatry, and Claire Gibson, MD, fourth-year resident, are lead and contributing authors, respectively, of a study in Journal of Psychopharmacology reporting that among individuals with psychosis, cannabis use is associated with lower levels of Anandamide, one of the main endogenous cannabinoids. This is the first published study on the peripheral levels of endocannabinoids in individuals with psychosis.Source: Journal of Psychopharmacology
Can Neuroimaging Reveal the Roots of Psychiatric Disorders? Not Just Yet
Neuroimaging technology has been shown to hold great promise in helping clinicians link specific symptoms of mental health disorders to abnormal patterns of brain activity. But a new Yale-led study shows there are still kinks to be ironed out before doctors can translate images of the brain to psychiatric disorders such as post-traumatic stress disorder (PTSD).Source: Yale News
Confronting Racially Exclusionary Practices in the Acquisition and Analyses of Neuroimaging Data
A new paper by Yale School of Medicine researchers challenges scientists in the global neuroscience community to create a more diverse representation of study participants through improved recruitment and enhanced methodological and analysis practices.
Newly Identified Neuromarker Reveals Clues About Drug and Food Craving
Hedy Kober, PhD, associate professor of psychiatry and psychology, is senior author of a study published in Nature Neuroscience that uncovered a pattern of brain activity that predicts drug and food craving, a potentially valuable biomarker for addiction.Source: Yale News
Krystal Research Published in The Lancet
Data from an early phase clinical trial of a drug being developed for adults living with schizophrenia was published December 15 in The Lancet. John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and professor of psychiatry, of neuroscience, and of psychology, and chair of the Yale Department of Psychiatry, is first author of the study of the drug emraclidine, developed by Cerevel Therapeutics.
Yale Department of Internal Medicine Celebrates Top Female Scientists
Last month, Research.com published the Best Female Scientists in 2022. The results were based on a ranking system which measures the impact of a researcher’s publications by combining the number of papers they have published and how often they are cited by other papers. 623 U.S.-based researchers appeared in list with three women representing the Yale Department of Internal Medicine.
Yale Study Seeks to Understand Neurobiology Underlying Bipolar Disorder Vs. Major Depressive Disorder
Yale scientists, including Sophie Holmes, PhD; Ruth Asch, PhD; and Irina Esterlis, PhD, used positron emission tomography to understand the neurobiology underlying bipolar disorder versus major depressive disorder. The findings were published in Biological Psychiatry.Source: Biological Psychiatry