In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Cellular garbage collectors implicated in development of Alzheimer’s
Lysosomes are cellular sanitation engineers that help clean up and recycle internal debris no longer needed by cells. So why do researchers find so many lysosomes within the neuronal projections surrounding amyloid plaques, a hallmark of Alzheimer’s Disease brain pathology?
Five young Yale scientists recognized for excellence
Five Yale faculty members are among the 84 young researchers designated as Faculty Scholars under a new program to promote early career scientists, launched by the Howard Hughes Medical Institute, the Simons Foundation, and the Bill and Melinda Gates Foundation.
A precise architecture, maintained as neurons grow
Nerve cells make their connections at junctions called synapses, following a precise architecture that is mostly laid out early in development. But how do the synapses maintain their correct positions as the animal grows? Yale scientists have produced the first evidence that this process relies on glial cells and identified a novel molecular pathway that could be linked in humans to neurological disease.
Yale researchers trick bacteria to deliver a safer vaccine
Vaccines that employ weakened but live pathogens to trigger immune responses have inherent safety issues but Yale researchers have developed a new trick to circumvent the problem — using bacteria’s own cellular mistakes to deliver a safe vaccine.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Yale biologist peers into inner working of the cell
Daniel Colón-Ramos, assistant professor of cell biology, studies the C. elegans nematode, and uses the latest microscopy technology to watch neurons locate a target and form precise synaptic connections, resulting in the neural circuits that underlie human behavior. In this talk at a TEDx event in San Juan in November 2011, Colón-Ramos discusses "The Value of Basic Research in Medicine."Source: Yale News
VA/Yale Researchers Lead Study That Assesses Well-being of U.S. Veterans
A new study led by the National Center for PTSD and Yale researchers analyzed data from a nationally representative sample of more than 2,400 U.S. veterans to examine subjective ratings and key sociodemographic, health, and psychosocial correlates of well-being. Peter Jongho Na, MD, MPH, and Robert Pietrzak, PhD, MPH, were lead and senior authors of the study, published in JAMA Network Open.
VA/Yale Researchers Lead Multi-ancestry Study of Genetics of Problematic Alcohol Use
A study led by VA Connecticut Healthcare Center/Yale researchers reveals ancestries around the world possess a shared genetic architecture for problematic alcohol use – habitual heavy drinking, accompanied by harmful consequences. Hang Zhou, PhD, assistant professor of psychiatry and of biomedical informatics & data science at Yale School of Medicine and VA Connecticut, and Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, and professor of genetics and of neuroscience at Yale School of Medicine and VA Connecticut, were first and senior authors, respectively.
Bile Duct Function and Disease Highlighted in New Research Study
Recent research from the Gupta Lab, led by Serrena Singh and supervised by Vikas Gupta, MD, PhD, assistant professor of medicine (digestive diseases), provides insights into the extrahepatic bile ducts. These bile ducts outside of the liver are a critical but poorly understood component of the human digestive system. This study, which was published in the journal Development Cell, marks a significant step forward in understanding diseases affecting these ducts, such as primary sclerosing cholangitis and cholangiocarcinoma.
Neural Patterns Differentiate Traumatic From Sad Autobiographical Memories in PTSD
Investigators from Yale and Mount Sinai schools of medicine studied the neural activity of 28 people diagnosed with post-traumatic stress disorder (PTSD). They found that autobiographical memories for sad and neutral memories are processed differently in the brain than for traumatic memories. The findings were published in Nature Neuroscience. The co-senior author is Ilan Harpaz-Rotem, PhD, professor of psychiatry and of psychology at Yale School of Medicine.
Thalidomide Use In Gastrointestinal Bleeding
Angiodysplasia, a type of benign vascular lesion made up of dilated blood vessels, is a common source of gastrointestinal bleeding from the small intestine. A recent editorial from Yale Internal Medicine’s Loren Laine, MD, professor of medicine and chief of digestive diseases, in the New England Journal of Medicine highlights novel findings from a recent multicenter, double-blind, randomized clinical trial evaluating thalidomide in the treatment of angiodysplasia-related bleeding.
The Effect of 10 Versus 20 Minutes of Mindfulness Meditation on State Mindfulness and Affect
Hedy Kober, PhD, associate professor of psychiatry and of psychology, is senior author of a paper in Scientific Reports that found a single session of mindfulness meditation improves state mindfulness regardless of whether sessions are 10 or 20 minutes long.Source: Scientific Reports
Implicit Bias From Providers Inhibits HCV Treatment
A new study reveals significant insights into the challenges that can occur for hepatitis C virus (HCV) micro-elimination efforts in people with HIV (PWH). Due to the opioid epidemic, the prevalence of co-infection with HIV and HCV has been increasing. If left untreated, HCV infection can lead to liver damage, cancer, and death. Although HIV requires lifelong therapy, HCV can be cured with a few months of oral medications.
Alcohol Research Conference Fosters Collaboration Across Specialties
Now in its second year, the Yale Conference for Alcohol Research and Education (YCARE) was held on September 30, 2023. Offering a comprehensive agenda of talks, panel discussions, and poster presentations, the all-day event brought together Yale's researchers, clinicians, and other stakeholders under the banner of alcohol research. Bubu Banini, MD, PhD, assistant professor of medicine (digestive diseases), Yale School of Medicine (YSM), spearheaded the conference, along with co-directors David Fiellin, MD, professor of medicine (general medicine) and emergency medicine, YSM, and public health, Yale School of Public Health; Graeme Mason, PhD, professor of radiology and biomedical imaging and of psychiatry, YSM; and Sherry McKee, PhD, professor of psychiatry, YSM.