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“Today’s event represents the best of what Yale stands for: an academic culture that values curiosity, nurtures discovery, and emboldens students to pursue careers of evidence-based inquiry and leadership,” stated Nancy J. Brown, MD, Jean and David W. Wallace Dean and C.N.H. Long Professor of Internal Medicine, at Yale School of Medicine’s annual Student Research Day, on May 6, 2025.

Yale researchers have discovered how typhoid fever triggers neurological symptoms, offering new insight into treatment options. 

Edwin Chapman is a professor of Neuroscience at the University of Wisconsin-Madison and an HHMI Investigator. The Chapman lab has spent the last 28 years studying the molecular mechanisms that mediate calcium-triggered exocytosis and their effects on synaptic function, as well as a variety of associated membrane trafficking events. Ahead of his talk on Tuesday, April 29th, I had the opportunity to chat with Dr. Chapman about his work, his approach to science, and what he takes away from all his years in the lab. This interview has been edited for length and clarity.

A $9 million bequest from the late Joseph Frederick Hoffman, PhD, Eugene Higgins Professor Emeritus of Cellular and Molecular Physiology at Yale School of Medicine (YSM), will establish funds to support research, students, patients, and more.

The new method offers a glimpse into the critical formative stages of RNA molecules—and may help lead to early therapeutic treatments when cellular production goes awry. 

Professors James Rothman and Joy Hirsch are both distinguished scientists and beloved resident fellows of Branford College—and hosts of monthly science-themed dinners at Mory’s. 

The new members, who have made key contributions across a range of fields, join previously elected fellows in helping to advance the common good.

As a scientist, starting from my postdoc and continuing in my own lab, we have helped redefine the role of the lysosome. Historically, it was considered a “boring organelle,” just the endpoint of degradation—a cellular trash can. But we’ve demonstrated that the lysosome is actually a sophisticated signaling center. We now call it the “metabolic computer” of the cell because it integrates information from other organelles and nutrient signals, particularly through mTOR kinase. The lysosome and mTOR communicate to make key metabolic decisions, balancing anabolism and catabolism. This has far-reaching implications for various cell types, including neurons, immune cells, and cancer cells.

Yale researchers have identified genes that regulate how DNA strands loop and fold. They could yield drug targets for genetic disorders and cancer.