The ISAC award provides seed funding for exceptionally innovative, disruptive (high-risk/high-reward) research relevant to the NIDDK Division of Kidney, Urologic, & Hematologic Diseases that has the potential to lead to groundbreaking or paradigm-shifting results that will change the field.
The von Blume lab investigates how neutrophils, frontline defenders against infections, are armed with proteins in distinct granule types. Regulated exocytosis activates them for chemotaxis, phagocytosis, and bacteria eradication. Yet, the molecular mechanisms of granule formation are unclear, limiting treatments for neutropenic disorders. The von Blume lab will investigate molecular mechanisms of neutrophil granule biogenesis that could pave the way for powerful therapeutic strategies. This project will be performed in collaboration with Shangqin Guo’s Yale Stem Cell Center lab.
- November 30, 2023
Avinash Kumar discusses science and life with our invited speaker Dr. Shixin Liu.
- November 27, 2023
A collaborative study led by Yale researchers reports the many gene expression changes that develop over the course of a neurodegenerative disorder called spinocerebellar ataxia type 1, shedding light on its progression.
- November 01, 2023
A breakthrough microscopy technique now enables researchers to observe previously unseen molecular processes within genetic material.
- September 27, 2023
In a new study published in Developmental Cell, a team of Yale researchers developed a new method to visualize spectrin, an essential component of an axon’s cytoskeleton, and uncovered two spectrin transport speeds – one slow, one ultra-slow.
- July 06, 2023
Investigators have developed a technique that makes microscopic specimens 4,000 times larger, letting researchers see fundamental genomic processes that previously were too small to visualize and evaluate hypotheses that until recently were untestable.
- June 16, 2023
Dr. Schuman talks about why she is inspired by neuroscience and the obstacles that she encountered along her impressive career.
- May 18, 2023
Dr. Xiaolei Su Receives prestigious Pershing Square Sohn Prize for Cancer Research
- May 15, 2023Source: Yale West Campus
Assemblies of tiny molecular proteins span the membranes that encapsulate our cells, directing cellular activities and regulating the transport of materials and information in and out. Scientists at the Yale Nanobiology Institute have decoded a chemical signal that allows them to capture these biological interactions directly from their natural habitat.
- May 12, 2023
A Yale-led study has discovered a new way to potentially treat aortic aneurysms in individuals with Marfan Syndrome.