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Breaking New Cell Biology Research

Amory Prize Is Presented to Haifan Lin

Yale President Peter Salovey hosted a celebration of stem cell biologist Haifan Lin as he received the Amory Prize from the American Academy of Arts and Sciences.

Source: American Academy of Arts & Sciences
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  • FLASH-PAINT enables highly-multiplexed super-resolution microscopy

    Super-resolution microscopy reveals the local distribution of proteins inside cells at the nanoscale but is in practice limited to visualizing only 2 to 3 different proteins in the same cell. FLASH-PAINT breaks this limit and empowers cell biologists to interrogate the complex spatial relationships between an essentially unlimited number of different molecules.

    Source: Cell
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  • Saving the Planet Through Biochemistry

    In her Nature Cell Biology piece, Karla Neugebauer discusses linking cell biology with climate change, highlighting her course on Biochemistry and Climate. She emphasizes the molecular basis of environmental impacts. Neugebauer urges integrating climate change into STEM curricula for a holistic understanding and inspires action from the next generation.

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  • A pathway that links lysosome stress to activation of a Parkinson's disease associated protein kinase

    This research reveals a novel pathway that integrates multiple signals related to lysosome stress in order to activate leucine rich repeat kinase 2 (LRRK2). Mutations that increase LRRK2 kinase activity are major contributors to Parkinson’s disease risk. Therefore, the lysosome perturbations that were defined in this study may increase Parkinson's disease risk by raising LRRK2 kinase activity. In other words, this research suggests that an exaggerated response to lysosome quality control may contribute Parkinson's disease risk.

    Source: bioRxiv
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  • Supersize the cell

    A breakthrough microscopy technique now enables researchers to observe previously unseen molecular processes within genetic material.

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  • Julia von Blume Receives Innovative Science Accelerator Award

    The ISAC award provides seed funding for exceptionally innovative, disruptive (high-risk/high-reward) research relevant to the NIDDK Division of Kidney, Urologic, & Hematologic Diseases that has the potential to lead to groundbreaking or paradigm-shifting results that will change the field. The von Blume lab investigates how neutrophils, frontline defenders against infections, are armed with proteins in distinct granule types. Regulated exocytosis activates them for chemotaxis, phagocytosis, and bacteria eradication. Yet, the molecular mechanisms of granule formation are unclear, limiting treatments for neutropenic disorders. The von Blume lab will investigate molecular mechanisms of neutrophil granule biogenesis that could pave the way for powerful therapeutic strategies. This project will be performed in collaboration with Shangqin Guo’s Yale Stem Cell Center lab.

    Source: ISAC AWARD PROGRAM, NIDDK Division of Kidney, Urologic, & Hematologic Diseases
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