Breaking New Cell Biology Research

Super-resolution microscopy reveals the local distribution of proteins inside cells at the nanoscale but is in practice limited to visualizing only 2 to 3 different proteins in the same cell. FLASH-PAINT breaks this limit and empowers cell biologists to interrogate the complex spatial relationships between an essentially unlimited number of different molecules.

Declines in the death rate for breast cancer have furthered overall progress in cancer mortality.

In her Nature Cell Biology piece, Karla Neugebauer discusses linking cell biology with climate change, highlighting her course on Biochemistry and Climate. She emphasizes the molecular basis of environmental impacts. Neugebauer urges integrating climate change into STEM curricula for a holistic understanding and inspires action from the next generation.

Scientist Haifan Lin has been awarded the Francis Amory Prize in Reproductive Medicine and Physiology by the American Academy of Arts & Sciences.

Avinash Kumar discusses science and life with our invited speaker Dr. Shixin Liu.

This research reveals a novel pathway that integrates multiple signals related to lysosome stress in order to activate leucine rich repeat kinase 2 (LRRK2). Mutations that increase LRRK2 kinase activity are major contributors to Parkinson’s disease risk. Therefore, the lysosome perturbations that were defined in this study may increase Parkinson's disease risk by raising LRRK2 kinase activity. In other words, this research suggests that an exaggerated response to lysosome quality control may contribute Parkinson's disease risk.

A breakthrough microscopy technique now enables researchers to observe previously unseen molecular processes within genetic material.

The ISAC award provides seed funding for exceptionally innovative, disruptive (high-risk/high-reward) research relevant to the NIDDK Division of Kidney, Urologic, & Hematologic Diseases that has the potential to lead to groundbreaking or paradigm-shifting results that will change the field. The von Blume lab investigates how neutrophils, frontline defenders against infections, are armed with proteins in distinct granule types. Regulated exocytosis activates them for chemotaxis, phagocytosis, and bacteria eradication. Yet, the molecular mechanisms of granule formation are unclear, limiting treatments for neutropenic disorders. The von Blume lab will investigate molecular mechanisms of neutrophil granule biogenesis that could pave the way for powerful therapeutic strategies. This project will be performed in collaboration with Shangqin Guo’s Yale Stem Cell Center lab.

Research Scientist Yeongho Kim and Professor Chris Burd provide their perspective on lipid sorting pathways that constitute the foundation of organelle biogenesis and membrane homeostasis.