About
Research
Overview
Dr. Kazmierczak studies opportunistic pathogens, with a primary emphasis on Pseudomonas aeruginosa. Her group is focused on understanding how microorganisms transition between commensal relationships with humans to causing disease. The following research projects are active in the laboratory.
- Regulation of genes involved in biofilm formation, Type 3 secretion and Type 6 secretion in Pseudomonas aeruginosa.
- Regulatory networks that control and coordinate pilus and flagellar assembly in response to environmental cues in Pseudomonas aeruginosa.
- Modulation of mammalian innate immune responses to Pseudomonas aeruginosa infection by the bacterial Type 3 secretion system apparatus and effectors.
- Single-cell analysis of Type 3 secretion system expression: how is phenotypic heterogeneity generated within a clonal population, and how does it affect fitness of a pathogen in the host?
- Novel approaches to understanding intrinsic antibiotic resistance and developing new antimicrobials.
- Acquisition of gut and airway microbiome populations in infants with Cystic Fibrosis and healthy controls: consequences for disease progression and development of inflammation.
Medical Research Interests
Bacterial Infections; Biomedical Research; Education, Medical, Graduate; Host-Pathogen Interactions; Immunity, Innate; Infectious Disease Medicine; Microbiology; Pseudomonas
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Infectious Diseases
Board Certifications
Infectious Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2019
- Original Certification Date
- 1999
News & Links
Media
- A Type 3 secretion system transcriptional reporter driving sfGFP expression reveals variation among genetically identical bacteria exposed to conditions that induce this virulence system.
News
- June 05, 2024
Welcome to the 2024 Yale BioMed Amgen, ACS, BP-Endure, and Summer Undergraduate Research Scholars
- July 05, 2023
Get In the Know! Infectious Diseases Fellowships
- July 21, 2022
Dr. Barbara Kazmierczak Is New Vice Chair, Basic Research
- June 27, 2022
Shung, Goldman-Israelow Present 2022 Dostanic Lectures