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Key Staff and Leadership

  • Program Co-Director

    Ensign Professor of Molecular Biophysics and Biochemistry and of Neuroscience; Deputy Dean for Research, Basic Science Departments

    Anthony J. Koleske is an expert in understanding the biochemical mechanisms that regulate neuronal dendrite and synapse development. After receiving a B.S. in Biochemistry and Molecular Biology at the University of Wisconsin-Madison, Dr. Koleske performed his Ph.D. studies with Dr. Richard Young at the Whitehead Institute/Massachusetts Institute of Technology. For his Ph.D. thesis, Dr. Koleske discovered the RNA polymerase II holoenzyme, an important advancement in understanding how gene transcription is turned on. Dr. Koleske went on to do a postdoctoral fellowship with Dr. David Baltimore at M.I.T., where he began his work studying cellular functions of Abl family kinases, which his laboratory has shown are essential regulators of the cytoskeleton in diverse cell types. Dr. Koleske joined the Department of Molecular Biophysics and Biochemistry at Yale University in 1998, where he currently is Professor and holds a joint appointment in the Department of Neuroscience. Dr. Koleske is the recipient of numerous awards including a Jane Coffin Childs Postdoctoral Fellowship, Special Fellowship and Scholar Awards from the Leukemia and Lymphoma Society, Young Investigator and Established Investigator Awards from NARSAD, an Established Investigator Award from the American Heart Association. He has served widely on review panels, including terms as Chair of the Basic Science Study Section for the American Heart Association and the Neurodifferentiation, Plasticity, Repair, and Rhythmicity Study Section of the NIH. He served as Director of the combined PhD programs in the Biological and Biomedical Sciences at Yale (2014-2019).  He also served Director of the China Scholarship Council-Yale World Scholars Program (2014-2019) and was a co-Director of the Yale BioMed SURF Amgen Scholars Program (w/Faye Rogers and Barbara Kazmierczak)(2015-2020).

  • Program Co-Director

    Gustavus and Louise Pfeiffer Research Foundation M.D.-Ph.D. Program Director and Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis; Professor, Microbial Pathogenesis; Director, MD-PhD Program, Yale University

    Dr. Kazmierczak received her Ph.D. from Rockefeller University (1993) and her M.D. from Cornell University Medical College (1994), both in New York City. She completed an Internal Medicine residency and Infectious Diseases fellowship training at the University of California, San Francisco, and joined the Yale faculty in 2001.  She is currently a Professor of Medicine and Microbial Pathogenesis, and Director of the MD-PhD program at Yale.

    Dr. Kazmierczak's research program is broadly focused on bacterial and host factors that allow opportunistic infections to occur.  Using Pseudomonas aeruginosa as a clinically relevant model, her lab addresses fundamental questions of how cell-envelope spanning bacterial machines - the Type 3 secretion system, Type 4 pili and polar flagellum - are assembled, regulated, and used during infection.  She has also identified host responses directed at components of these virulence associated structures, in particular those mediated by the NLRC4 inflammasome. Inflammatory responses to bacteria are also a focus of her work on microbiome-host interactions in infants with Cystic Fibrosis, where her lab has used longitudinal data acquired over five years from cohorts of patients and controls to understand gut microbiome composition and the inflammatory and metabolic responses at this site. 

    Dr. Kazmierczak has been recognized as a Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases (2007), a Donaghue Investigator (2002), and a Hellman Family Fellow (2002).  She is a Fellow of the Infectious Diseases Society of America and an elected member of the American Society for Clinical Investigation and the American Academy for Microbiology.