2025
Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, Schwab A, Edwards D, Taylor H, Wenner M. Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women. AJP Heart And Circulatory Physiology 2025, 328: h327-h332. PMID: 39773019, PMCID: PMC12175985, DOI: 10.1152/ajpheart.00815.2024.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousEndothelin B Receptor AntagonistsEstradiolFemaleHumansMicrocirculationMiddle AgedOligopeptidesPiperidinesPostmenopauseReceptor, Endothelin BSkinTime FactorsTransdermal PatchVasodilationConceptsPostmenopausal womenExogenous estradiol administrationEndothelin B receptorEstradiol administrationPremenopausal womenLactated RingeHealthy postmenopausal womenYoung womenLaser Doppler flowmetryEndothelin-BVasodilatory responseTransdermal patchDoppler flowmetryCutaneous microcirculationVasodilationEstradiolAdministrationWomenReceptorsRingerBlockadeFlowmetry
2011
Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome
Wenner MM, Taylor HS, Stachenfeld NS. Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. The Journal Of Physiology 2011, 589: 4671-4679. PMID: 21825025, PMCID: PMC3213415, DOI: 10.1113/jphysiol.2011.216218.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesEndothelin A Receptor AntagonistsEndothelin B Receptor AntagonistsEndothelin-1Endothelin-2Endothelium, VascularFemaleHumansMicrocirculationMicrovesselsOligopeptidesPeptides, CyclicPiperidinesPolycystic Ovary SyndromeReceptor, Endothelin AReceptor, Endothelin BRegional Blood FlowSkinVasoconstrictionVasodilationYoung AdultConceptsPolycystic ovary syndromeET-B receptorsLocal skin warmingOvary syndromeSkin warmingLower vascular reactivityPeripheral microvascular functionLaser Doppler flowmetrySkin blood flowGroup of womenDose-response curveBlunted responsivenessEndothelin BEndothelin AEndothelial dysfunctionVascular reactivityVasoconstrictive responseVasodilatory responseMicrovascular functionCutaneous microvasculatureIntradermal microdialysisAntagonist infusionEndothelin-1Receptor responsivenessReceptor subtypes
2010
Acid regulation of NaDC-1 requires a functional endothelin B receptor
Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisAnimalsBiological TransportCell LineDicarboxylic Acid TransportersDisease Models, AnimalEndothelin B Receptor AntagonistsEndothelin-1Hydrogen-Ion ConcentrationKidneyMiceMice, KnockoutMicrovilliOligopeptidesOpossumsOrganic Anion Transporters, Sodium-DependentPiperidinesProtein Structure, TertiaryReceptor, Endothelin AReceptor, Endothelin BRecombinant Fusion ProteinsSignal TransductionSymportersTime FactorsTransfectionConceptsEndothelin-1Endothelin-B receptor antagonistFunctional endothelin B receptorsStimulatory effectAcid-stimulatory effectET-1 effectsB receptor antagonistNHE3 activityEndothelin B receptorWild-type miceET-1 stimulationMajor physiological stimulusNaDC-1Acid ingestionReceptor antagonistCitrate reabsorptionReceptor expressionCitrate excretionOpossum kidneyAcid loadB receptorAcid feedingPhysiological stimuliStimulationMice
2009
Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism
Trow TK, Taichman DB. Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism. Respiratory Medicine 2009, 103: 951-962. PMID: 19304472, DOI: 10.1016/j.rmed.2009.02.016.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionEndothelin receptor antagonistsArterial hypertensionET-1Development of PAHManagement of PAHPathogenesis of PAHEndothelin receptor blockadeLiver function abnormalitiesPlacebo-controlled trialNitric oxide-mediated pathwayClinical study resultsGood clinical resultsClinical treatment studiesUnited States FoodPeripheral edemaFunction abnormalitiesReceptor blockadeDual antagonismDual blockadeSafety profileET receptorsEndothelin-1Head studiesReceptor antagonist
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