2024
Akt is a mediator of artery specification during zebrafish development
Zhou W, Ghersi J, Ristori E, Semanchik N, Prendergast A, Zhang R, Carneiro P, Baldissera G, Sessa W, Nicoli S. Akt is a mediator of artery specification during zebrafish development. Development 2024, 151: dev202727. PMID: 39101673, PMCID: PMC11441982, DOI: 10.1242/dev.202727.Peer-Reviewed Original ResearchArterial specificationEndothelial cellsVascular endothelial growth factor ADorsal aortaEndothelial growth factor ASingle-cell RNA sequencing analysisGrowth factor AArtery endothelial cellsEmbryonic cardiovascular systemConstitutively active Akt1Ligand-independent activationActivation of NotchArteriovenous malformationsCongenital malformationsRNA sequencing analysisVEGF-AProtein kinase BUpstream of NotchSequence analysisCardiovascular developmentSpecific expressionAkt kinaseActive Akt1Zebrafish developmentCardiovascular system
2018
Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning
Shetty R, Joshi D, Jain M, Vasudevan M, Paul J, Bhat G, Banerjee P, Abe T, Kiyonari H, VijayRaghavan K, Inamdar M. Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Scientific Reports 2018, 8: 5632. PMID: 29618843, PMCID: PMC5884795, DOI: 10.1038/s41598-018-24014-w.Peer-Reviewed Original ResearchConceptsMouse developmentGenome-wide transcriptome analysisFirst knockout mouseDirectional cell migrationExtracellular matrix organizationExtra-embryonic tissuesSpheroid sprouting assaysEmbryonic day 9.5Endothelial cellsCKO embryosCardiovascular patterningNull embryosTranscriptome analysisRudhiraVascular patterningCardiovascular developmentCytoskeletal proteinsMolecular processesMatrix organizationCell adhesionCell migrationDay 9.5Peptidase activityYolk sacEssential role
2017
Lead promotes abnormal angiogenesis induced by CCM3 gene defects via mitochondrial pathway
Sun Y, Zhang H, Xing X, Zhao Z, He J, Li J, Chen J, Wang M, He Y. Lead promotes abnormal angiogenesis induced by CCM3 gene defects via mitochondrial pathway. Journal Of Developmental Origins Of Health And Disease 2017, 9: 182-190. PMID: 29110746, DOI: 10.1017/s2040174417000782.Peer-Reviewed Original ResearchConceptsMouse embryosYolk sacHeterozygous mouse embryosGene defectsCCM3 genesPrimary human umbilical vein endothelial cellsLead exposureMitochondrial DNAEmbryonic developmentMtDNA biogenesisMitochondrial morphologyCardiovascular developmentHuman umbilical vein endothelial cellsMitochondrial pathwayGene knockoutEndothelial cellsUmbilical vein endothelial cellsVascular developmentMitochondria pathwayVein endothelial cellsPrimary cellsGenesRNA expressionCell proliferationEmbryos
2015
Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner
Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Developmental Biology 2015, 407: 195-210. PMID: 26434918, PMCID: PMC5312697, DOI: 10.1016/j.ydbio.2015.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBranchial RegionCardiovascular SystemCell LineageEmbryo, MammalianFemaleFibronectinsIntegrin alpha5beta1LIM-Homeodomain ProteinsMice, KnockoutModels, BiologicalMorphogenesisMutationNeural CrestOrgan SpecificityPharynxPhenotypePregnancySignal TransductionStem CellsT-Box Domain ProteinsThymus GlandTranscription FactorsConceptsPharyngeal arch arteriesCardiovascular developmentIntegrin α5Pharyngeal arch mesodermCell type-specific mannerCell typesMid-gestation lethalityType-specific mannerDistinct cell typesCardiac outflow tractMorphogenetic defectsPharyngeal regionMouse embryogenesisConditional mutantsExtracellular matrix glycoproteinEmbryonic developmentMutagenesis studiesCardiovascular morphogenesisNeural crestPAA formationSurface ectodermDefective formationArch arteriesFN1Matrix glycoprotein
2013
Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development. Circulation Research 2013, 113: 22-31. PMID: 23603510, PMCID: PMC3739451, DOI: 10.1161/circresaha.113.301324.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAdipokinesAnimalsApelinApelin ReceptorsCardiovascular AbnormalitiesCardiovascular SystemEndocardiumEndothelium, VascularFemaleFetal HeartGene Expression Regulation, DevelopmentalGenes, LethalGTP-Binding Protein alpha Subunits, G12-G13Histone DeacetylasesIntercellular Signaling Peptides and ProteinsKruppel-Like Transcription FactorsMaleMEF2 Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutMyogenic Regulatory FactorsPhosphorylationProtein Processing, Post-TranslationalReceptors, G-Protein-CoupledSignal TransductionTranscription, GeneticConceptsCardiovascular developmentVentricular wall developmentMyocyte enhancer factor 2Embryonic lethal phenotypeCardiovascular developmental defectsFactor 2Apelin-APJHistone deacetylase 4MEF2 functionModel organismsLethal phenotypeEmbryonic lethalityTranscriptional targetsMEF2 activationKrüppel-like factor 2Wall developmentHDAC5 phosphorylationCushion formationNuclear localizationVascular smooth muscle cellsEndothelial cellsDevelopmental defectsMolecular mechanismsCritical regulatorLigand apelin
2009
Separating genetic and hemodynamic defects in neuropilin 1
Jones E, Yuan L, Breant C, Watts R, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1. The FASEB Journal 2009, 23: 311.1-311.1. DOI: 10.1096/fasebj.23.1_supplement.311.1.Peer-Reviewed Original ResearchVascular developmentProper vascular developmentYolk sac blood vesselsGenetic defectsMutant embryosBiochemical signalingYolk sac arteriesCardiovascular developmentMouse embryo cultureEmbryo growthBlood flowPhysiological functionsHemodynamic defectsVascular defectsVascular formationEmbryo cultureBiological senseNeuropilin-1Proper blood flowPhysical forcesProteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers
2008
Separating Genetic and Hemodynamics Effects In Nrp1 Knockout Embryos
Jones E, Yuan L, Breant C, Watts R, Eichmann A. Separating Genetic and Hemodynamics Effects In Nrp1 Knockout Embryos. The FASEB Journal 2008, 22: 1143.2-1143.2. DOI: 10.1096/fasebj.22.1_supplement.1143.2.Peer-Reviewed Original Research
2007
Biomechanical Gene Activation During Cardiovascular Development
Jones E, Le Noble F, Yuan L, Eichmann A. Biomechanical Gene Activation During Cardiovascular Development. The FASEB Journal 2007, 21: a201-a201. DOI: 10.1096/fasebj.21.5.a201-a.Peer-Reviewed Original ResearchCardiovascular developmentPhysical forcesGene activationEmbryonic developmentVenous differentiationBiochemical signalingMechanical cuesGene expressionEmbryo growthEphB4 receptorVascular formationNeuropilin-2Mechanical forcesNeuropilin-1Blood fluid dynamicsExternal stimuliGenesCardiovascular systemSignalingEmbryosEphrinB2DifferentiationRegulationDynamic interactionExpression
2006
The roles of nitric oxide in murine cardiovascular development
Nath AK, Madri JA. The roles of nitric oxide in murine cardiovascular development. Developmental Biology 2006, 292: 25-33. PMID: 16442519, DOI: 10.1016/j.ydbio.2005.12.039.Peer-Reviewed Original ResearchConceptsMammalian organ systemsCardiovascular developmentCell contextBiological functionsOrgan system developmentRedox milieuRegulatory roleDiverse arrayRole of NOBiochemical environmentOrgan systemsNitric oxidePathological statesParadoxical actionPotential implicationsRoleReproductionProduction of NOSystem developmentCytoprotectionWide range
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