2017
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell BR, Angeli J, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell 2017, 171: 273-285. PMID: 28985560, PMCID: PMC5685180, DOI: 10.1016/j.cell.2017.09.021.Peer-Reviewed Original ResearchConceptsRegulated cell deathCell deathPathological cell deathBiosynthesis of glutathioneNumerous biological processesTumor suppressor functionIron-dependent accumulationAreas of biologyRedox biologyFatty acid metabolismBiological processesCellular membranesAmino acidsHeat stressCoenzyme QFerroptosisAcid metabolismBiologyLethal levelsFatty acidsKidney degenerationCancer therapyDegenerative diseasesMetabolismMammals
2016
Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
Truong TH, Ung PM, Palde PB, Paulsen CE, Schlessinger A, Carroll KS. Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase. Cell Chemical Biology 2016, 23: 837-848. PMID: 27427230, PMCID: PMC4958504, DOI: 10.1016/j.chembiol.2016.05.017.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpidermal growth factor receptor kinaseGrowth factor receptor kinaseDetailed functional analysisNew electrostatic interactionsFirst detailed functional analysisKinase regulationS-sulfenylationRedox biologyReceptor kinaseCatalytic loopGrowth factor receptorMolecular basisChronic oxidative stressKinase activityFunctional analysisCatalytic importanceRedox activationFactor receptorMajor classesOxidative stressCatalytic efficiencyData highlightMolecular dynamics simulationsActivation
2015
Regulation of thrombosis and vascular function by protein methionine oxidation
Gu S, Stevens J, Lentz S. Regulation of thrombosis and vascular function by protein methionine oxidation. Blood 2015, 125: 3851-3859. PMID: 25900980, PMCID: PMC4473114, DOI: 10.1182/blood-2015-01-544676.Peer-Reviewed Original ResearchConceptsProtein methionine oxidationMethionine residuesRedox regulation of protein functionRegulation of protein functionOxidation-sensitive methionine residuesMethionine oxidationMethionine sulfoxide reductaseIntracellular redox stateRegulatory domainProtein functionSulfoxide reductaseCellular homeostasisRedox regulationStereospecific enzymesReactive oxygen speciesRegulation of thrombosisSignaling moleculesGene expressionRedox biologyRedox sensorCell adhesionRedox balanceMethionine sulfoxideProteinInflammatory gene expression
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