2022
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
Black E, Joo Y, Kabeche L. Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma. Biochemical Journal 2022, 479: 2345-2349. PMID: 36416754, PMCID: PMC9704517, DOI: 10.1042/bcj20220461.Peer-Reviewed Original ResearchConceptsReplication stressChk1 activityDNA damage response pathwayChk1 inhibitorsDNA replication stressInhibitor resistanceDamage response pathwayGenome instabilityPI3K/AktResponse pathwaysMolecular mechanismsNovel roleChk1Cancer therapyCancer developmentFemale fertilityDevelopment of resistancePathwayLethal levelsMultiple mechanismsAlternative pathwayNF-κBDrug resistanceIntriguing targetDisease states
2017
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell BR, Angeli J, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell 2017, 171: 273-285. PMID: 28985560, PMCID: PMC5685180, DOI: 10.1016/j.cell.2017.09.021.Peer-Reviewed Original ResearchConceptsRegulated cell deathCell deathPathological cell deathBiosynthesis of glutathioneNumerous biological processesTumor suppressor functionIron-dependent accumulationAreas of biologyRedox biologyFatty acid metabolismBiological processesCellular membranesAmino acidsHeat stressCoenzyme QFerroptosisAcid metabolismBiologyLethal levelsFatty acidsKidney degenerationCancer therapyDegenerative diseasesMetabolismMammals
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