2020
Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits
Datta D, Enwright JF, Arion D, Paspalas CD, Morozov YM, Lewis DA, Arnsten AFT. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers In Neuroanatomy 2020, 14: 578483. PMID: 33328902, PMCID: PMC7714912, DOI: 10.3389/fnana.2020.578483.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexSmooth endoplasmic reticulumPrefrontal cortexHuman dlPFCPrimate dorsolateral prefrontal cortexHuman post-mortem tissueInternal calcium releasePrimate association corticesPost-mortem tissueMacaque dorsolateral prefrontal cortexPrimate dlPFCAxospinous synapsesPV interneuronsGlutamatergic connectionsGlutamatergic synapsesPyramidal cellsAxon terminalsTransmitter releaseTau phosphorylationDendritic spinesPDE4 isozymesAssociation cortexLayer IIICAMP actionPostsynaptic labeling
2018
Parvalbumin expression affects synaptic development and physiology at the Drosophila larval NMJ
He T, Nitabach MN, Lnenicka GA. Parvalbumin expression affects synaptic development and physiology at the Drosophila larval NMJ. Journal Of Neurogenetics 2018, 32: 209-220. PMID: 30175644, DOI: 10.1080/01677063.2018.1498496.Peer-Reviewed Original ResearchConceptsSingle action potentialAP trainsAction potentialsPresynaptic CaMuscle fiber 5Synaptic developmentMotor terminal growthPaired-pulse facilitationParvalbumin expressionFibers 5Transmitter releasePV expressionSynaptic boutonsIb terminalsSynaptic enhancementSynaptic facilitationOGB-1Electrophysiological recordingsParvalbuminRate of riseHomeostatic responseFluorescent CaLarval NMJsDrosophila neuronsResidual Ca
2008
Nicotine and brain development
Dwyer JB, Broide RS, Leslie FM. Nicotine and brain development. Birth Defects Research Part C Embryo Today Reviews 2008, 84: 30-44. PMID: 18383130, DOI: 10.1002/bdrc.20118.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyMaternal smokingPharmacologic propertiesBrain developmentSudden infant death syndromeFetal central nervous systemAuditory cognitive dysfunctionActivation of nAChRsInfant death syndromeCentral nervous systemNumerous brain regionsNicotinic acetylcholine receptorsCell survivalLigand-gated ion channelsLong-term alterationsSpecific neural circuitryCritical developmental periodPregnant womenReplacement therapyTobacco cessationCholinergic modulationFunctional statusNeonatal brainPreclinical studiesTransmitter release
2001
Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels
B.Levitan I, Kaczmarek L. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels. 2001, 253-284. DOI: 10.1093/oso/9780195145236.003.0011.Peer-Reviewed Original ResearchTarget neuronsIon channelsParticular neurotransmitterNeuroactive substancesTransmitter releaseNervous systemNeurotransmitter receptorsNerve cellsHormone receptorsNeuronsTarget cellsReceptorsBiological responsesNeurotransmittersIntercellular communicationCell typesExtracellular signalsChemical signalsTransduction mechanismsResponseCellsNeurohormones
1997
Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model
Mennerick S, Zenisek D, Matthews G. Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model. Journal Of Neurophysiology 1997, 78: 51-62. PMID: 9242260, DOI: 10.1152/jn.1997.78.1.51.Peer-Reviewed Original ResearchConceptsBipolar neuronsGoldfish retinaSynaptic terminalsBipolar cellsIntact goldfish retinaDepolarization-evoked increaseSingle synaptic terminalsSynaptic transmitter releaseWhole-cell recordingsSoma/dendritesMorphological correlatesElectrotonic architectureTwo-compartment modelTransmitter releaseBiexponential time courseCell recordingsPatch pipetteNeuronsCompartment modelRetinaLines of evidenceTime courseSomaCells
1989
Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers
Benveniste H, Hüttemeier P, Johansen F, Diemer N. Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers. 1989, 266-273. DOI: 10.1007/978-3-642-85863-5_34.Peer-Reviewed Original ResearchIntracellular calcium accumulationCalcium accumulationNeuronal cell injuryNMDA receptor blockerExcessive transmitter releaseIntracellular calcium concentrationFinal common pathwayReceptor blockersNeuronal injuryDentate hilusTransmitter releaseCell injuryCalcium channelsCalcium concentrationCommon pathwayInjuryCell deathPossible effectsHilusBlockers
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