2022
Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia
Yang Q, Zhang Y, Yang K, Niu Y, Fan F, Chen S, Luo X, Tan S, Wang Z, Tong J, Yang F, Li C, Tan Y. Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia. Frontiers In Psychiatry 2022, 13: 1036421. PMID: 36339840, PMCID: PMC9632432, DOI: 10.3389/fpsyt.2022.1036421.Peer-Reviewed Original ResearchFirst-episode schizophreniaP50 auditory gatingNon-smoking patientsHealthy controlsAuditory gatingSerum kynurenineSerum levelsS2/S1 ratioAcid levelsKynurenine pathway metabolitesFirst-episode patientsNegative Syndrome ScaleKynurenine acidEpisode patientsNeuroactive metabolitesKynurenine pathwayPatientsS1 ratioSyndrome ScaleCognitive impairmentS1-S2SchizophreniaPathway metabolitesS1 amplitudeKynurenine
2018
Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology. Cerebral Cortex 2018, 29: 2716-2727. PMID: 29920597, PMCID: PMC7302691, DOI: 10.1093/cercor/bhy140.Peer-Reviewed Original ResearchConceptsTgF344-AD ratsHippocampal theta oscillationsAlzheimer's diseaseDisease pathologyTheta-phase gamma-amplitude couplingAge-matched wild-type counterpartsAD pathological featuresDisease-modifying therapiesAccumulation of amyloidPredictive animal modelsAlzheimer's disease pathologyHigh-voltage spindlesTheta oscillationsSignificant age-dependent declineAge-dependent declineHippocampal excitabilitySharp-wave ripplesAβ accumulationNeuronal lossAD ratsPathological featuresUrethane anesthesiaAD patientsAuditory gatingAD drugs
2015
Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy
Nagy D, Stoiljkovic M, Menniti FS, Hajós M. Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy. Neuropsychopharmacology 2015, 41: 1486-1494. PMID: 26404843, PMCID: PMC4832008, DOI: 10.1038/npp.2015.298.Peer-Reviewed Original ResearchConceptsAuditory-evoked potentialsAntidepressant effectsSynaptic potentiationAntidepressant efficacyAuditory gatingRapid-onset antidepressant effectsEffects of ketaminePrimary auditory cortexReceptor channel blockerDifferent acute effectsNMDA receptor inhibitionNegative allosteric modulatorsPotential mechanistic underpinningsReceptor inhibitionSystemic administrationAcute effectsNeurophysiological biomarkersTranslatable biomarkersChannel blockersDrug eliminationAuditory cortexNeurophysiological parametersDrug AdministrationGamma band powerKetamine
2014
Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor
Nagy D, Tingley FD, Stoiljkovic M, Hajós M. Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor. Experimental Neurology 2014, 263: 122-131. PMID: 25315303, DOI: 10.1016/j.expneurol.2014.10.001.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesAcoustic StimulationAnimalsAuditory CortexDisease Models, AnimalElectrophysiologyEnzyme InhibitorsEvoked Potentials, AuditoryHippocampusHuntington DiseaseMiceMice, Inbred C57BLMice, TransgenicPyrazolesPyrimidinonesRatsRats, Sprague-DawleyRats, TransgenicSensory GatingConceptsBACHD transgenic ratsPrimary auditory cortexAuditory gatingDisease patientsHuntington's diseaseAuditory cortexBACHD ratsTransgenic ratsPF-04447943Sub-chronic treatmentPotential translational biomarkersHuntington's disease patientsTransgenic animal modelsBasic neuropathologyDaily administrationTranslational biomarkersQ175 miceNeurophysiological abnormalitiesSystemic administrationNeurophysiological biomarkersLast treatmentAnimal modelsTransgenic miceGamma band powerBrain regions
2012
Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo
Kleiman R, Chapin D, Christoffersen C, Freeman J, Fonseca K, Geoghegan K, Grimwood S, Guanowsky V, Hajós M, Harms J, Helal C, Hoffmann W, Kocan G, Majchrzak M, McGinnis D, McLean S, Menniti F, Nelson F, Roof R, Schmidt A, Seymour P, Stephenson D, Tingley F, Vanase-Frawley M, Verhoest P, Schmidt C. Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo. Journal Of Pharmacology And Experimental Therapeutics 2012, 341: 396-409. PMID: 22328573, DOI: 10.1124/jpet.111.191353.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP Phosphodiesterases3',5'-Cyclic-GMP PhosphodiesterasesAnimalsAvoidance LearningBrainCholinergic AgentsCyclic GMPFemaleHumansMacaca fascicularisMaleMemoryMiceMice, Inbred C57BLMotor ActivityNeuronsNeurotransmitter AgentsPhosphodiesterase InhibitorsRatsRats, Long-EvansRats, WistarSensory GatingStereotyped BehaviorSynaptic TransmissionConceptsNeurotransmitter systemsDisruption of working memoryMultiple neurotransmitter systemsDiverse neurotransmitter systemsInhibition of PDE9ARegulation of synaptic plasticityDose-dependent accumulation of cGMPSensorimotor gatingSerotonergic neurotransmissionAuditory gatingSpatial memoryRodent central nervous systemAccumulation of cGMPSensory processingResponses to cholinergicPDE9A inhibitionSynaptic plasticityDose-dependent accumulationIn vivo effectsCentral nervous systemHuman cortexPDE9A inhibitorsMemoryPDE9ACerebrospinal fluid
2004
The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats
Hajós M, Hurst R, Hoffmann W, Krause M, Wall T, Higdon N, Groppi V. The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats. Journal Of Pharmacology And Experimental Therapeutics 2004, 312: 1213-1222. PMID: 15523001, DOI: 10.1124/jpet.104.076968.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorAnimalsBenzamidesBenzylidene CompoundsBridged Bicyclo CompoundsCells, CulturedElectroencephalographyEvoked Potentials, Auditorygamma-Aminobutyric AcidHippocampusIntralaminar Thalamic NucleiNicotinic AgonistsPyridinesRatsRats, Sprague-DawleyReceptors, NicotinicSynapsesConceptsGABAergic synaptic activityAgonist PNU-282987PNU-282987Auditory gatingAlpha7 nAChRsAnesthetized ratsSynaptic activityHomomeric alpha7 nicotinic acetylcholine receptorsChloral hydrate-anesthetized ratsAlpha7 nicotinic acetylcholine receptorCultured rat hippocampal neuronsHippocampal GABAergic neurotransmissionReticular thalamic neuronsTreatment of schizophreniaHippocampal CA3 regionNovel selective agonistAuditory-evoked potentialsAuditory gating deficitsRat hippocampal neuronsNicotinic acetylcholine receptorsHippocampal oscillatory activityWhole-cell currentsAntagonist methyllycaconitineGABAergic neurotransmissionPotential pharmacotherapy
2003
Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats
Krause M, Hoffmann W, Hajós M. Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats. Biological Psychiatry 2003, 53: 244-253. PMID: 12559658, DOI: 10.1016/s0006-3223(02)01463-4.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAnimalsArousalAttentionBrain MappingDextroamphetamineDopamineElectroencephalographyEvoked Potentials, AuditoryHaloperidolHippocampusIntralaminar Thalamic NucleiMaleNerve NetNeuronsRatsRats, Sprague-DawleySignal Processing, Computer-AssistedSynaptic TransmissionTheta RhythmConceptsAuditory gatingNRT neuronsHippocampal auditory gatingD-amphetamineSensory gatingThalamic neuronsThalamic reticular nucleus neuronsReticular nucleus neuronsThalamic sensory gatingReticular thalamic neuronsThalamic reticular nucleusSensory processingAuditory stimuliThalamic sensory processingPsychostimulant d-amphetamineAuditory sensory gatingSingle-unit activityHippocampal theta activityBilateral auditory stimuliSensory information processingAntipsychotic haloperidolHippocampal electroencephalogramDopamine hyperfunctionNucleus neuronsRat thalamus
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