2006
Activation of α7 acetylcholine receptors augments stimulation‐induced hippocampal theta oscillation
Siok C, Rogers J, Kocsis B, Hajós M. Activation of α7 acetylcholine receptors augments stimulation‐induced hippocampal theta oscillation. European Journal Of Neuroscience 2006, 23: 570-574. PMID: 16420464, DOI: 10.1111/j.1460-9568.2005.04560.x.Peer-Reviewed Original ResearchConceptsHippocampal theta oscillationsPNU-282987Stimulation-induced hippocampal theta oscillationTheta oscillationsCholinergic septal neuronsAgonist PNU-282987Brainstem reticular formationAlpha7 nicotinic receptorsΑ7 acetylcholine receptorsHippocampal oscillatory activitySeptal neuronsMuscarinic receptorsGABAergic interneuronsSelective alpha7Alpha7 nAChRsSystemic administrationReticular formationNicotinic receptorsElectrical stimulationAcetylcholine receptorsOscillatory activityReceptorsNAChRsAlpha7Neurons
2004
The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats
Hajós M, Hurst R, Hoffmann W, Krause M, Wall T, Higdon N, Groppi V. The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats. Journal Of Pharmacology And Experimental Therapeutics 2004, 312: 1213-1222. PMID: 15523001, DOI: 10.1124/jpet.104.076968.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorAnimalsBenzamidesBenzylidene CompoundsBridged Bicyclo CompoundsCells, CulturedElectroencephalographyEvoked Potentials, Auditorygamma-Aminobutyric AcidHippocampusIntralaminar Thalamic NucleiNicotinic AgonistsPyridinesRatsRats, Sprague-DawleyReceptors, NicotinicSynapsesConceptsGABAergic synaptic activityAgonist PNU-282987PNU-282987Auditory gatingAlpha7 nAChRsAnesthetized ratsSynaptic activityHomomeric alpha7 nicotinic acetylcholine receptorsChloral hydrate-anesthetized ratsAlpha7 nicotinic acetylcholine receptorCultured rat hippocampal neuronsHippocampal GABAergic neurotransmissionReticular thalamic neuronsTreatment of schizophreniaHippocampal CA3 regionNovel selective agonistAuditory-evoked potentialsAuditory gating deficitsRat hippocampal neuronsNicotinic acetylcholine receptorsHippocampal oscillatory activityWhole-cell currentsAntagonist methyllycaconitineGABAergic neurotransmissionPotential pharmacotherapy
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