2025
Topography of putative bi-directional interaction between hippocampal sharp-wave ripples and neocortical slow oscillations
Swanson R, Chinigò E, Levenstein D, Vöröslakos M, Mousavi N, Wang X, Basu J, Buzsáki G. Topography of putative bi-directional interaction between hippocampal sharp-wave ripples and neocortical slow oscillations. Neuron 2025, 113: 754-768.e9. PMID: 39874961, DOI: 10.1016/j.neuron.2024.12.019.Peer-Reviewed Original ResearchConceptsWide-field imagingUP/DOWN statesDown stateDownstream cortical regionsUp-transitionHippocampal sharp-wave ripplesMulti-unit activitySharp-wave ripplesSlow oscillationsExcitation systemStateRetrosplenial cortexHigher modulationExcitationNeocortical slow oscillationsOscillationsCouplingDorsal neocortex
2018
Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology. Cerebral Cortex 2018, 29: 2716-2727. PMID: 29920597, PMCID: PMC7302691, DOI: 10.1093/cercor/bhy140.Peer-Reviewed Original ResearchConceptsTgF344-AD ratsHippocampal theta oscillationsAlzheimer's diseaseDisease pathologyTheta-phase gamma-amplitude couplingAge-matched wild-type counterpartsAD pathological featuresDisease-modifying therapiesAccumulation of amyloidPredictive animal modelsAlzheimer's disease pathologyHigh-voltage spindlesTheta oscillationsSignificant age-dependent declineAge-dependent declineHippocampal excitabilitySharp-wave ripplesAβ accumulationNeuronal lossAD ratsPathological featuresUrethane anesthesiaAD patientsAuditory gatingAD drugs
2013
Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice
Kanak DJ, Rose GM, Zaveri HP, Patrylo PR. Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice. PLOS ONE 2013, 8: e61364. PMID: 23593474, PMCID: PMC3620228, DOI: 10.1371/journal.pone.0061364.Peer-Reviewed Original ResearchConceptsCA3-CA1 circuitCA1 stratum pyramidaleSharp-wave ripplesAged miceStratum pyramidaleHippocampal slicesAge groupsCarbachol-induced gamma oscillationsSpontaneous sharp wavesCA1 stratum radiatumGamma oscillationsStratum oriensUnidentified neuronsAged neuronsStratum radiatumCA1 subregionNeuronal activityAdult miceSharp wavesUnit activityRipple oscillationsCollateral responsesMiceCA3Pyramidale
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