Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo
Kleiman R, Chapin D, Christoffersen C, Freeman J, Fonseca K, Geoghegan K, Grimwood S, Guanowsky V, Hajós M, Harms J, Helal C, Hoffmann W, Kocan G, Majchrzak M, McGinnis D, McLean S, Menniti F, Nelson F, Roof R, Schmidt A, Seymour P, Stephenson D, Tingley F, Vanase-Frawley M, Verhoest P, Schmidt C. Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo. Journal Of Pharmacology And Experimental Therapeutics 2012, 341: 396-409. PMID: 22328573, DOI: 10.1124/jpet.111.191353.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP Phosphodiesterases3',5'-Cyclic-GMP PhosphodiesterasesAnimalsAvoidance LearningBrainCholinergic AgentsCyclic GMPFemaleHumansMacaca fascicularisMaleMemoryMiceMice, Inbred C57BLMotor ActivityNeuronsNeurotransmitter AgentsPhosphodiesterase InhibitorsRatsRats, Long-EvansRats, WistarSensory GatingStereotyped BehaviorSynaptic TransmissionConceptsNeurotransmitter systemsDisruption of working memoryMultiple neurotransmitter systemsDiverse neurotransmitter systemsInhibition of PDE9ARegulation of synaptic plasticityDose-dependent accumulation of cGMPSensorimotor gatingSerotonergic neurotransmissionAuditory gatingSpatial memoryRodent central nervous systemAccumulation of cGMPSensory processingResponses to cholinergicPDE9A inhibitionSynaptic plasticityDose-dependent accumulationIn vivo effectsCentral nervous systemHuman cortexPDE9A inhibitorsMemoryPDE9ACerebrospinal fluid
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